[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632374":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":19,"centralContacts":24,"locations":33,"responsibleParty":53,"collaborators":18,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":18,"eligibilityCriteria":60,"healthyVolunteers":57,"sex":61,"minAge":62,"maxAge":18,"enrollmentInfo":63,"targetDuration":18,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":76,"overallStatus":36,"whyStopped":18,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Institute of HIV Research and Innovation Foundation, Thailand","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Transgender-tailored Harm Reduction Service","Participants (transgender women, transgender men, and non-binary persons engaging in chemsex or substance use) will receive a comprehensive, transgender-tailored harm reduction service over a 12-month follow-up period. The intervention includes substance use harm reduction, sexual health services including HIV pre-exposure prophylaxis (PrEP), mental health screening and support, and socio-legal assistance. Participants will attend study visits at baseline and months 3, 6, 9, and 12, with assessments of behavioral risks, substance use, mental health, HIV\u002FSTI testing, and social outcomes.",[12],"Behavioral: Transgender-tailored Harm Reduction Service",[14],{"type":15,"name":9,"description":16,"armGroupLabels":17,"otherNames":18},"BEHAVIORAL","A comprehensive, multi-component harm reduction service tailored for transgender individuals engaging in chemsex, substance use, implemented at Tangerine Clinic.\n\nThe intervention includes:\n\n1. Substance Use Harm Reduction\n\n   * Drug-specific literacy, safer use education\n   * Counseling on overdose prevention and safer consumption\n   * Provision of harm reduction kits\n2. Sexual Health Services\n\n   * HIV testing\n   * STI screening and treatment (CT\u002FNG, syphilis, HBV, HCV)\n   * Provision of PrEP including:\n   * Daily oral PrEP\n   * Event-driven PrEP\n3. Mental Health Services\n\n   * Screening using:\n   * Electronic Mental Wellness Tool\n   * Community Mental Wellness Tool\n   * Referral to psychiatric care when indicated\n4. Socio-legal Support\n\n   * Counseling on stigma, discrimination, and legal issues\n   * Support for gender-affirming care access",[9],null,[20],{"name":21,"affiliation":22,"role":23},"Nittaya Phanuphak, MD,PhD.","Institute of HIV Research and Innovation (IHRI)","PRINCIPAL_INVESTIGATOR",[25,29],{"name":21,"role":26,"phone":27,"phoneExt":18,"email":28},"CONTACT","6681 825 3544","nittaya.p@ihri.org",{"name":30,"role":26,"phone":31,"phoneExt":18,"email":32},"Rena Janamnuaysook, MBA","6698 516 4562","rena.j@ihri.org",[34],{"facility":35,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Tangerine Clinic, Institute of HIV Research and Innovation","RECRUITING","Pathum Wan","Bangkok","10330","Thailand","TH",{"type":43,"coordinates":44},"Point",[45,46],100.52329,13.73698,{"lat":46,"lon":45},[49,52],{"name":50,"role":26,"phone":51,"phoneExt":18,"email":28},"Nittaya Phanuphak, MD.,Ph.D.","+66 2 1605371",{"name":30,"role":26,"phone":51,"phoneExt":18,"email":32},{"type":54,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100632374","the-implementation-of-a-trans-tailored-harm-reduction-service-for-transgender-persons-in-relation-to-chemsex-and-substance-use-it-rex-100632374",false,"NCT07512856","The Implementation of a Trans-tailored Harm Reduction Service for Transgender Persons in Relation to chemsEX and Substance Use (iT-REX)","Inclusion Criteria:\n\n* Self-identified transgender women, transgender men, or non-binary persons\n* Age ≥18 years\n* HIV-negative\n* Engaged in chemsex or substance use within past 12 months\n* Able to provide informed consent\n\nExclusion Criteria:\n\n• Inability to communicate in Thai sufficiently to complete study procedures","ALL","18 Years",{"count":64,"type":65},140,"ESTIMATED","INTERVENTIONAL",[68],"NA","This study evaluates a comprehensive transgender-tailored harm reduction service for transgender women, transgender men, and non-binary individuals engaging in chemsex or substance use in Thailand, focusing on PrEP uptake, HIV\u002FSTI outcomes, mental health, and socio-legal impacts.",[71,72,73,74,75],"HIV Prevention","Substance Use","Mental Health Disorders","Sexually Transmitted Infections (STIs)","Chemsex",[77],"PrEP, Harm reduction, Chemsex, Transgender","2026-04-02",{"date":80,"type":81},"2026-04-06","ACTUAL",{"date":83,"type":81},"2024-02-01",{"date":85,"type":65},"2028-02-01",{"name":5,"class":6},1]