[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628786":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":62,"collaborators":25,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":25,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":25,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":89,"whyStopped":25,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Ulm","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intranasal Insulin Spray","EXPERIMENTAL","160 Units of human insulin as nasal spray",[13],"Other: Spiroergometer test with intranasal insulin spray",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Spray","PLACEBO_COMPARATOR","Nasal spray containing placebo solution",[19],"Other: Spiroergometer test with intranasal placebo spray",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Spiroergometer test with intranasal insulin spray","Participants will undergo a 60 min bicycle spiroergometer test and intranasal insulin spray. Intranasal insulin will be administered 30 minutes prior to the start of the physical activity.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Spiroergometer test with intranasal placebo spray","Participants will undergo a 30 min bicycle spiroergometer test and intranasal placebo spray. To mimic insulin spill-over from nasal spray into systemic circulation, an i.v. insulin bolus of 3 mU × kg-1. will be administered over 15 minutes 30 minutes prior to the start of the physical activity on the placebo spray day. On the insulin spray day a comparable amount of saline will be infused.",[15],[31],{"name":32,"affiliation":5,"role":33},"Martin Heni, MD","PRINCIPAL_INVESTIGATOR",[35,39],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","+4973150044505","martin.heni@uniklinik-ulm.de",{"name":40,"role":36,"phone":41,"phoneExt":25,"email":42},"Sabrina Wangler","+4973150044782","sabrina.wangler@uniklinik-ulm.de",[44],{"facility":45,"status":25,"city":46,"state":25,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Ulm University Hospital","Ulm","89081","Germany","DE",{"type":51,"coordinates":52},"Point",[53,54],9.99155,48.39841,{"lat":54,"lon":53},[57,58],{"name":40,"role":36,"phone":25,"phoneExt":41,"email":42},{"name":59,"role":36,"phone":60,"phoneExt":25,"email":61},"Kathrin Popp, MD","+4973150044839","kathrin.popp@uniklinik-ulm.de",{"type":33,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Martin Heni","Head of the Section Endocrinology and Diabetology, Full Professorship (W3) for Endocrinology and Diabetology","100628786","the-importance-of-insulin-action-in-the-brain-for-the-immune-system-during-physical-activity-overweight-100628786",false,"NCT07466173","The Importance of Insulin Action in the Brain for the Immune System During Physical Activity-Overweight","Inclusion Criteria:\n\n* BMI \\> 28 kg\u002Fm2\n* no known primary disease\n* hormonal contraception with a single-phase preparation\n\nExclusion Criteria:\n\n* alcohol or drug abuse\n* At screening: Hb \\\u003C 12 g\u002Fdl for women and Hb \\\u003C 14 g\u002Fdl for men\n* Any (clinical) condition that would endanger participant's safety or question scientific success according to a physician's opinion.",true,"ALL","18 Years","30 Years",{"count":76,"type":77},8,"ESTIMATED","INTERVENTIONAL",[80],"NA","The goal of this clinical trial is to clarify the interaction of central insulin action and physical activity with the immune system. Therefore, participants will undergo bicycle spiroergometer tests. This approach will be compared between days with insulin delivery to the brain as nasal spray and days with placebo spray. In another trial (NCT06552130) lean participants already have been tested. Significant effects on circulating cytokines could be identified. In this amendment, overweight persons in which brain insulin resistance is expected will be tested.",[83],"Insulin Sensitivity",[85,86,87,88],"brain insulin action","autonomic nervous system","physical activity","immune system","NOT_YET_RECRUITING","2026-03-11",{"date":92,"type":93},"2026-03-16","ACTUAL",{"date":95,"type":77},"2026-04",{"date":97,"type":77},"2027-06",{"name":5,"class":6},1]