[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625082":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":22,"responsibleParty":45,"collaborators":49,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":66,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":74,"overallStatus":25,"whyStopped":10,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"University of Malaya","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Adults with Liver Cirrhosis",null,"Adults aged 18 to 75 years with a clinically confirmed diagnosis of liver cirrhosis who are enrolled to complete the Liver Cirrhosis Cognitive Decline Scale (LiCCoS) and related cognitive assessments as part of an observational, cross-sectional study. No intervention or change in medical care is involved",[13,18],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Rajat Rana, PhD","CONTACT","601127873697","rajatrana91@gmail.com",{"name":19,"role":15,"phone":20,"phoneExt":10,"email":21},"Plaban Nag, Pharm.D","916909952755","plabannag@gmail.com",[23],{"facility":24,"status":25,"city":26,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Maharishi Markandeshwar (Deemed to be University)","RECRUITING","Ambāla","Haryana","133207","India","IN",{"type":32,"coordinates":33},"Point",[34,35],76.79782,30.36099,{"lat":35,"lon":34},[38,39,41,43],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},{"name":19,"role":40,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"name":42,"role":40,"phone":10,"phoneExt":10,"email":10},"Rajnandani Prajapat, Rajnandani",{"name":44,"role":40,"phone":10,"phoneExt":10,"email":10},"Shivani Billa, Pharm.D",{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dr. Rajat Rana","Researcher",[50],{"name":51,"class":6},"Maharishi Markendeswar University (Deemed to be University)","100625082","the-liver-cirrhosis-cognitive-decline-scale-liccos-100625082",false,"NCT07418008","The Liver Cirrhosis Cognitive Decline Scale (LiCCoS)","Development and Psychometric Validation of The Liver Cirrhosis Cognitive Decline Scale (LiCCoS)","LiCCoS","Inclusion Criteria:\n\n* Age 18-75 years.\n* Documented clinical diagnosis of liver cirrhosis based on imaging, histology, or validated clinical criteria.\n* Able to read and understand the language of the cognitive tests.\n* Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>75 years\n* Known case of Overt Hepatic Encephalopathy defined as Grade II or higher on the West Haven criteria \\[25\\].\n* Use of central nervous system depressants, anticholinergics, or psychotropics initiated or changed within the past 4 weeks.\n* Known case of Severe uncorrected visual or hearing impairment limiting ability to complete cognitive testing.\n* Known case of Any neurological and psychological disorders, substance use disorder and sleep disorders.\n* Known case of Severe systemic illness (e.g., end-stage renal disease, decompensated heart failure) that may independently impair cognition or limit participation.","ALL","18 Years","75 Years",{"count":64,"type":65},230,"ESTIMATED","1 Day","OBSERVATIONAL","The goal of this observational study is to develop and test a new questionnaire called the Liver Cirrhosis Cognitive Decline Scale (LiCCoS) for adults with liver cirrhosis. This questionnaire is designed to help identify problems with thinking and daily mental functioning that are common in people with liver cirrhosis but are often missed during routine care.\n\nPeople with liver cirrhosis may experience problems such as forgetfulness, slowed thinking, trouble paying attention, or difficulty planning everyday tasks. These problems can affect daily life, safety, and treatment adherence. Existing cognitive tests often require special training or equipment and may not fully reflect how people experience these difficulties in daily life. This study aims to create a simple, patient-reported tool that captures these concerns in an easy and practical way.\n\nThe main questions this study aims to answer are:\n\n1. Can the LiCCoS questionnaire reliably measure cognitive difficulties in adults with liver cirrhosis?\n2. Does the questionnaire correctly reflect differences in cognitive function across levels of liver disease severity?\n3. Do LiCCoS scores relate to results from commonly used cognitive screening tests?\n\nParticipants will be adults aged 18 to 75 years who have a confirmed diagnosis of liver cirrhosis and are attending outpatient clinics. Participation is voluntary.\n\nParticipants will:\n\nProvide basic background information, such as age and medical history\n\nComplete the LiCCoS questionnaire about their thinking and daily mental functioning\n\nComplete standard cognitive screening tests commonly used in clinical care\n\nThis study does not involve any treatment or change in medical care. The information collected will be used only for research purposes. The results are expected to help develop a reliable and easy-to-use tool that can support early recognition of cognitive difficulties in people with liver cirrhosis and improve communication between participants and health care providers.",[70,71,72,73],"Liver Cirrhosis","Cognitive Dysfunction","Hepatic Encephalopathy","Neurocognitive Disorders",[58,75,76,77,78,79,80,81,82,83],"Liver cirrhosis","Cognitive impairment","Cognitive dysfunction","Hepatic encephalopathy","Patient-reported outcome measure","Psychometric validation","Scale development","Cognitive assessment","Chronic liver disease","2026-02-10",{"date":86,"type":87},"2026-02-18","ACTUAL",{"date":89,"type":87},"2025-12-15",{"date":91,"type":65},"2026-11-30",{"name":5,"class":6},1]