[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588910":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":10,"responsibleParty":22,"collaborators":10,"id":26,"slug":27,"hasResults":28,"nctId":29,"briefTitle":30,"officialTitle":30,"acronym":31,"eligibilityCriteria":32,"healthyVolunteers":33,"sex":34,"minAge":35,"maxAge":36,"enrollmentInfo":37,"targetDuration":10,"studyType":40,"phases":10,"briefSummary":41,"conditions":42,"keywords":10,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":10},{"fullName":5,"class":6},"Second Hospital of Shanxi Medical University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with coronary heart disease or diabetes under different course of disease",null,"Select patients with coronary heart disease and diabetes who meet the standard, take 8ml of blood from the elbow vein, 4ml of blood for centrifugation, take serum, and use chromatography column to separate and extract β 1-AA; 4ml is used to detect endogenous N\u002FOFQ and β 1-AA levels using an ELISA kit.",[13],{"name":14,"affiliation":5,"role":15},"yi Han","STUDY_DIRECTOR",[17],{"name":18,"role":19,"phone":20,"phoneExt":10,"email":21},"xinyu shang","CONTACT","18451655670","13513520761@163.com",{"type":23,"investigatorFullName":24,"investigatorTitle":25,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Zheng Guo","Professor","100588910","the-mechanism-of-endogenous-nociceptinorphanin-fqnofq-and-1-adrenoceptor-autoantibody-in-promoting-ischemic-arrhythmia-in-rats-100588910",false,"NCT06947551","The Mechanism of Endogenous Nociceptin\u002FOrphanin FQ(N\u002FOFQ) and β1-adrenoceptor Autoantibody in Promoting Ischemic Arrhythmia in Rats","tmoenabaaipiai","Inclusion Criteria:1) Inclusion criteria for patients with diabetes: refer to the diagnostic criteria for type 2 diabetes (T2DM) in the Chinese Guidelines for the Prevention and Treatment of Type 2 diabetes (2017) 2) Inclusion criteria for patients with coronary heart disease: patients with clinically diagnosed coronary heart disease according to the 1979 WHO Diagnostic Criteria for Ischemic Heart Disease, and exclusion criteria include heart failure, tumor, immune disease and diabetes. -\n\nExclusion Criteria:Exclusion criteria for patients with coronary heart disease: including heart failure, tumor, immune disease and diabetes. -",true,"ALL","18 Years","85 Years",{"count":38,"type":39},60,"ESTIMATED","OBSERVATIONAL","In the early stage of ischemic arrhythmia, endogenous N\u002FOFQ regulates the expression of β 1-AA, mediates the internalization of β 1-AR by PKC\u002FERK1\u002F2, and thus affects the occurrence of arrhythmia. Further clarify the regulatory mechanism of N\u002FOFQ on β 1-AR internalization and arrhythmia, providing experimental basis for drug development and target exploration of clinical ischemic arrhythmia; To observe the relationship between endogenous N\u002FOFQ and β 1-AA in serum of patients with coronary heart disease and diabetes.",[43],"Acute Myocardial Ischemia","NOT_YET_RECRUITING","2025-04-25",{"date":47,"type":48},"2025-04-27","ACTUAL",{"date":50,"type":39},"2025-05-01",{"date":52,"type":39},"2026-06-01",{"name":5,"class":6}]