[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634437":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":26,"centralContacts":36,"locations":46,"responsibleParty":63,"collaborators":10,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":10,"eligibilityCriteria":70,"healthyVolunteers":67,"sex":71,"minAge":72,"maxAge":10,"enrollmentInfo":73,"targetDuration":10,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":10,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Zhongnan Hospital","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Case Group A",null,"PACG patients with zonular laxity",[13],"Other: No Additional Experimental Intervention",{"label":15,"type":10,"description":16,"interventionNames":17},"Case Group B","PACG patients without zonular laxity",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Control Group","cataract patients without a history or signs of glaucoma",[13],[23],{"type":6,"name":24,"description":24,"armGroupLabels":25,"otherNames":10},"No Additional Experimental Intervention",[9,15,19],[27,30,32],{"name":28,"affiliation":5,"role":29},"Wen Zeng, doctor","STUDY_DIRECTOR",{"name":31,"affiliation":5,"role":29},"Nan Zhang, doctor",{"name":33,"affiliation":34,"role":35},"Xuetian Yu, student","The Second Clinical College of Wuhan University","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},"Min Ke, doctor","CONTACT","18672395959","Keminyk@163.com",{"name":43,"role":39,"phone":44,"phoneExt":10,"email":45},"Xiaomin Chen, doctor","13657237773","xminchen@whu.edu.cn",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Zhongnan Hospital of Wuhan University","RECRUITING","Wuhan","Hubei","430000","China","CN",{"type":56,"coordinates":57},"Point",[58,59],114.26667,30.58333,{"lat":59,"lon":58},[62],{"name":38,"role":39,"phone":40,"phoneExt":10,"email":41},{"type":64,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100634437","the-multi-omics-analysis-of-lens-zonule-relaxation-in-the-pacg-pathogenesis-100634437",false,"NCT07539675","The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis","Inclusion Criteria:\n\n* Clinically diagnosed with primary angle-closure glaucoma (PACG)\n* Aged ≥ 50 years, no gender restriction\n* Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity\n* Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology\n* Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery\n\nExclusion Criteria:\n\n* Secondary glaucoma\n* History of previous intraocular surgery\n* Systemic diseases that can cause abnormal ocular zonules\n* Other severe ocular diseases\n* Long-term use of medications affecting connective tissue metabolism","ALL","50 Years",{"count":74,"type":75},150,"ESTIMATED","OBSERVATIONAL","Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.",[79],"Primary Angle-Closure Glaucoma","2026-04-13",{"date":82,"type":83},"2026-04-20","ACTUAL",{"date":85,"type":83},"2025-10-01",{"date":87,"type":75},"2027-09-30",{"name":5,"class":6},1]