[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100511945":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":107,"collaborators":109,"id":131,"slug":132,"hasResults":133,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":138,"sex":139,"minAge":140,"maxAge":12,"enrollmentInfo":141,"targetDuration":12,"studyType":144,"phases":145,"briefSummary":147,"conditions":148,"keywords":150,"overallStatus":38,"whyStopped":12,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":162},{"fullName":5,"class":6},"Wake Forest University Health Sciences","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Attention Control","NO_INTERVENTION","This comparison group provides attention, social interaction, and healthy lifestyle classes. There will be 4, 1-hour face-to-face group meetings per year featuring community health professionals, quarterly newsletters, and quarterly text messages.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Diet and Exercise","EXPERIMENTAL","The dietary component of the weight loss intervention is characterized by the frequency of contacts, methods to induce dietary restriction, and behavioral therapy strategies. The first 6 months of the diet program is an energy-restricted diet with the option of using partial meal replacements and nutritious snacks (Rapid Nutrition, PLC). The weight loss goal for the diet and exercise group is a minimum of 10% of baseline body weight by the end of year 1. The weight loss phase is followed by 3 years of a weight-loss maintenance program, with the goal of sustaining the achieved weight loss. The exercise component includes 60-minute sessions 2 days per week for 48 months.",[18],"Behavioral: Diet and Exercise",[20],{"type":21,"name":14,"description":22,"armGroupLabels":23,"otherNames":12},"BEHAVIORAL","Group and individual weight loss and weight maintenance sessions combined with exercise throughout the 48 months.",[14],[25],{"name":26,"affiliation":27,"role":28},"Stephen P Messier, Ph.D.","Wake Forest University","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":12,"email":34},"Jovita Newman","CONTACT","336-758-3969","jollajk@wfu.edu",[36,57,74,86],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Brigham and Women's Hospital","RECRUITING","Boston","Massachusetts","02115","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-71.05977,42.35843,{"lat":48,"lon":47},[51,55],{"name":52,"role":32,"phone":53,"phoneExt":12,"email":54},"Paul Oh","617-525-8349","paoh@bwh.harvard.edu",{"name":56,"role":28,"phone":12,"phoneExt":12,"email":12},"Elena Losina, Ph.D.",{"facility":58,"status":38,"city":59,"state":60,"zip":61,"country":42,"countryCode":43,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"University of North Carolina at Chapel Hill","Chapel Hill","North Carolina","27516",{"type":45,"coordinates":63},[64,65],-79.05584,35.9132,{"lat":65,"lon":64},[68,72],{"name":69,"role":32,"phone":70,"phoneExt":12,"email":71},"Cortney Armitano-Lago","919-962-2025","Cortney_Lago@med.unc.edu",{"name":73,"role":28,"phone":12,"phoneExt":12,"email":12},"Leigh Callahan, Ph.D.",{"facility":27,"status":38,"city":75,"state":60,"zip":76,"country":42,"countryCode":43,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"Winston-Salem","27109",{"type":45,"coordinates":78},[79,80],-80.24422,36.09986,{"lat":80,"lon":79},[83,84],{"name":31,"role":32,"phone":33,"phoneExt":12,"email":34},{"name":85,"role":28,"phone":12,"phoneExt":12,"email":12},"Shannon Mihalko, Ph.D.",{"facility":87,"status":38,"city":88,"state":12,"zip":12,"country":89,"countryCode":90,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"University of Sydney","Sydney","Australia","AU",{"type":45,"coordinates":92},[93,94],151.20732,-33.86785,{"lat":94,"lon":93},[97,101,105],{"name":98,"role":32,"phone":99,"phoneExt":12,"email":100},"Frances Daley","+61 434 023 970","frances.daley@sydney.edu.au",{"name":102,"role":32,"phone":103,"phoneExt":12,"email":104},"Karen Bracken","+61 2 9926 4928","karen.bracken@sydney.edu.au",{"name":106,"role":28,"phone":12,"phoneExt":12,"email":12},"David Hunter, MBBS, Ph.D., MSc",{"type":108,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR",[110,113,115,117,120,122,124,127,129],{"name":111,"class":112},"National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)","NIH",{"name":114,"class":6},"Arthritis Foundation",{"name":116,"class":112},"National Center for Complementary and Integrative Health (NCCIH)",{"name":118,"class":119},"Office of Disease Prevention","UNKNOWN",{"name":121,"class":112},"Office of Research on Women's Health (ORWH)",{"name":123,"class":112},"Office of Behavioral and Social Sciences Research (OBSSR)",{"name":125,"class":126},"Centers for Disease Control and Prevention","FED",{"name":128,"class":6},"University of Missouri-Columbia",{"name":130,"class":119},"Rapid Nutrition PLC","100511945","the-osteoarthritis-prevention-study-100511945",false,"NCT05946044","The Osteoarthritis Prevention Study","TOPS","Inclusion Criteria:\n\n* Female\n* BMI ≥ 30 kg\u002Fm2\n* An eligible knee will have no OA by xray and MRI\n* No or infrequent knee pain (\\\u003C 15 days\u002Fmonth) in the same knee\n\nExclusion Criteria:\n\n* symptomatic or severe coronary artery disease\n* unable to walk without a device\n* blindness\n* type 1 diabetes\n* active treatment for cancer\n* during the past 12 months knee fracture, anterior cruciate ligament (ACL), medial collateral ligament (MCL), or meniscus injury with or without surgical repair\n* knee injection during the past 6 months\n* bilateral knee OA by x-ray Kellgren-Lawrence (KL) ≥ 2\n* bilateral knee OA by MRI\n* bilateral symptomatic knee OA (frequent bilateral knee pain \\> 15 days per month)\n* BMI\\\u003C 30.0 kg\u002Fm2\n* male sex\n* claustrophobia\n* contraindication to MRI including body weight \\> 300 lbs or knee coil does not fit\n* unwillingness or inability to change eating and physical activity habits due to environment\n* cannot speak and read English\n* planning to leave area \\> 2 months during the 48-month intervention period",true,"FEMALE","50 Years",{"count":142,"type":143},1230,"ESTIMATED","INTERVENTIONAL",[146],"NA","The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural Magnetic Resonance Imaging (MRI) knee OA. Secondary aims will determine the intervention effects on pain, mobility, health-related quality of life, knee joint compressive forces, inflammatory measures, weight loss, exercise self-efficacy, and cost-effectiveness of this intervention.",[149],"Osteoarthritis, Knee",[151,152],"Obesity","Knee Pain","2025-07-18",{"date":155,"type":156},"2025-07-23","ACTUAL",{"date":158,"type":156},"2024-03-21",{"date":160,"type":143},"2029-07-31",{"name":27,"class":6},4]