[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100490977":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":10,"centralContacts":10,"locations":44,"responsibleParty":57,"collaborators":10,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":10,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":10,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":10,"overallStatus":80,"whyStopped":10,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Assiut University","OTHER",[8,17],{"label":9,"type":6,"description":10,"interventionNames":11},"Non-obese hypertensive pregnant women",null,[12,13,14,15,16],"Drug: Anti-Hypertensive","Radiation: Ultrasound","Radiation: Doppler ultrasound","Diagnostic Test: complete blood count","Diagnostic Test: Body mass index",{"label":18,"type":6,"description":10,"interventionNames":19},"Obese hypertensive pregnant women",[12,13,14,15,16],[21,26,31,35,40],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"DRUG","Anti-Hypertensive","For control of the blood pressure",[9,18],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"RADIATION","Ultrasound","For assessment of gestational age and fetal weight",[9,18],{"type":27,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"Doppler ultrasound","Umbilical artery Doppler assessment",[9,18],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":10},"DIAGNOSTIC_TEST","complete blood count","For assessment of platelet count",[9,18],{"type":36,"name":41,"description":42,"armGroupLabels":43,"otherNames":10},"Body mass index","for assessment of maternal weight during pregnancy",[9,18],[45],{"facility":46,"status":10,"city":47,"state":10,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":10},"Women Health Hospital - Assiut university","Asyut","71111","Egypt","EG",{"type":52,"coordinates":53},"Point",[54,55],31.18368,27.18096,{"lat":55,"lon":54},{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Mohammed Khairy Ali","Assistant Professor","100490977","the-outcomes-of-hypertension-in-obese-versus-non-obese-pregnant-women-100490977",false,"NCT05673135","The Outcomes of Hypertension in Obese Versus Non-obese Pregnant Women","The Differences in Adverse Maternal and Fetal Outcomes Related to Hypertension in Obese Versus Non-obese Pregnant Women","Inclusion Criteria:\n\n1. Women aged from 20-35 years.\n2. Pregnant women from 28-30 weeks.\n3. Pregnant women with a singleton pregnancy.\n4. Women with chronic or gestational hypertension.\n5. Women with normal baseline investigations (uncomplicated hypertension).\n6. Obese women and non-obese women.\n\nExclusion Criteria:\n\n1. Women with preeclampsia\u002Feclampsia.\n2. Women need urgent termination of pregnancy.\n3. Women with co-morbidities such as diabetes, renal diseases, cardiac ...etc.\n4. Women with confirmed fetal malformation.\n5. Women who will refuse to participate.","FEMALE","25 Years","35 Years",{"count":72,"type":73},260,"ESTIMATED","INTERVENTIONAL",[76],"NA","Hypertensive disorders of pregnancy, include pre-existing and gestational hypertension, preeclampsia, and eclampsia, it complicates up to 10% of pregnancies and represents a significant cause of maternal and perinatal morbidity and mortality. Following the \"National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy\" recommendation is currently a systolic blood pressure (SBP) ⩾ of 140 mmHg and diastolic blood pressure (DBP) ⩾ of 90 mmHg. The diagnosis generally requires two separate measurements. Accepted across international guidelines are the following four categories: Chronic\u002Fpre-existing hypertension (Hypertension discovered preconception or prior to 20 weeks gestation), Gestational hypertension (Hypertension that appears de novo after 20 weeks gestation and normalizes after pregnancy), Preeclampsia-eclampsia (De novo hypertension after 20 weeks' gestation accompanied by proteinuria, other features of maternal organ dysfunction or uteroplacental dysfunction), Chronic\u002Fpre-existing hypertension with superimposed preeclampsia-eclampsia. Over the past 2 decades, extensive epidemiologic studies have clearly established that obesity is a major risk for gestational hypertension and preeclampsia. The risk of preeclampsia typically doubles with each 5-7 kg\u002Fm2 increase in pre-pregnancy. The mechanisms have only been partially explored; increased cytokine-mediated inflammation and oxidative stress, increased shear stress, dyslipidemia, and increased sympathetic activity1 have all been proposed as possible pathways. Few studies have examined the relationship between pre-pregnancy BMI, gestational weight gain (GWG), and the risk of preeclampsia. So, our study aims to evaluate the adverse maternal and fetal outcomes related to hypertension in obese and non-obese pregnant women.",[79],"Hypertension in Pregnancy","NOT_YET_RECRUITING","2024-04-23",{"date":83,"type":84},"2024-04-24","ACTUAL",{"date":86,"type":73},"2025-04-01",{"date":88,"type":73},"2026-10",{"name":5,"class":6},1]