[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100561320":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":28,"centralContacts":42,"locations":52,"responsibleParty":381,"collaborators":11,"id":383,"slug":384,"hasResults":385,"nctId":386,"briefTitle":387,"officialTitle":387,"acronym":11,"eligibilityCriteria":388,"healthyVolunteers":385,"sex":389,"minAge":390,"maxAge":11,"enrollmentInfo":391,"targetDuration":11,"studyType":394,"phases":395,"briefSummary":397,"conditions":398,"keywords":401,"overallStatus":55,"whyStopped":11,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":410,"completionDateStruct":412,"leadSponsor":414,"locationsCount":415},{"fullName":5,"class":6},"Inari Medical","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"FlowTriever","ACTIVE_COMPARATOR",null,[13],"Device: FlowTriever System",{"label":15,"type":10,"description":11,"interventionNames":16},"Standard of Care",[17],"Procedure: Standard of Care",[19,24],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":11},"DEVICE","FlowTriever System","Mechanical thrombectomy for pulmonary embolism",[9],{"type":25,"name":15,"description":26,"armGroupLabels":27,"otherNames":11},"PROCEDURE","Standard of care treatment for pulmonary embolism",[15],[29,33,36,39],{"name":30,"affiliation":31,"role":32},"Nicolas Meneveau, MD PhD","Centre Hospitalier Universitaire Hôpital Jean Minjoz, Besançon, France","PRINCIPAL_INVESTIGATOR",{"name":34,"affiliation":35,"role":32},"Stavros Konstantinides, MD PhD","Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Germany",{"name":37,"affiliation":38,"role":32},"John M Moriarty, MD","Westwood Imaging Center & Interventional Radiology Clinic - UCLA, CA, USA",{"name":40,"affiliation":41,"role":32},"Jay Giri, MD, MPH","Penn Medicine, Philadelphia, PA, USA",[43,48],{"name":44,"role":45,"phone":46,"phoneExt":11,"email":47},"Tine Devolder","CONTACT","+32 476 53 88 05","tine.devolder@inarimedical.com",{"name":49,"role":45,"phone":50,"phoneExt":11,"email":51},"Jen Foss","978-587-6598","jenifer.foss@stryker.com",[53,70,83,95,108,121,134,146,159,174,186,199,212,224,238,249,260,271,284,295,307,318,329,342,354,368],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"Yale University","RECRUITING","New Haven","Connecticut","06519","United States","US",{"type":62,"coordinates":63},"Point",[64,65],-72.92816,41.30815,{"lat":65,"lon":64},[68],{"name":69,"role":45,"phone":11,"phoneExt":11,"email":11},"Christopher Moore, MD",{"facility":71,"status":55,"city":72,"state":73,"zip":74,"country":59,"countryCode":60,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"Orlando Health Regional Medical Center","Orlando","Florida","32806",{"type":62,"coordinates":76},[77,78],-81.37924,28.53834,{"lat":78,"lon":77},[81],{"name":82,"role":45,"phone":11,"phoneExt":11,"email":11},"Joel Garcia-Fernandez, MD",{"facility":84,"status":55,"city":85,"state":73,"zip":86,"country":59,"countryCode":60,"cosmosGeoPoint":87,"geoPoint":91,"contacts":92},"Sarasota Memorial Hospital","Sarasota","34239",{"type":62,"coordinates":88},[89,90],-82.53065,27.33643,{"lat":90,"lon":89},[93],{"name":94,"role":45,"phone":11,"phoneExt":11,"email":11},"Clinton Wrigley, MD",{"facility":96,"status":55,"city":97,"state":98,"zip":99,"country":59,"countryCode":60,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"Emory University","Atlanta","Georgia","30322",{"type":62,"coordinates":101},[102,103],-84.38798,33.749,{"lat":103,"lon":102},[106],{"name":107,"role":45,"phone":11,"phoneExt":11,"email":11},"Wissam Jaber, MD",{"facility":109,"status":55,"city":110,"state":111,"zip":112,"country":59,"countryCode":60,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"University of Mississippi Medical Center","Jackson","Mississippi","39216",{"type":62,"coordinates":114},[115,116],-90.18481,32.29876,{"lat":116,"lon":115},[119],{"name":120,"role":45,"phone":11,"phoneExt":11,"email":11},"Gabriel Hernandez, MD",{"facility":122,"status":55,"city":123,"state":124,"zip":125,"country":59,"countryCode":60,"cosmosGeoPoint":126,"geoPoint":130,"contacts":131},"Northwell Health","Bay Shore","New York","11706",{"type":62,"coordinates":127},[128,129],-73.24539,40.7251,{"lat":129,"lon":128},[132],{"name":133,"role":45,"phone":11,"phoneExt":11,"email":11},"Wally Omar, MD",{"facility":135,"status":55,"city":136,"state":124,"zip":137,"country":59,"countryCode":60,"cosmosGeoPoint":138,"geoPoint":142,"contacts":143},"SUNY, The University at Buffalo","Buffalo","14203",{"type":62,"coordinates":139},[140,141],-78.87837,42.88645,{"lat":141,"lon":140},[144],{"name":145,"role":45,"phone":11,"phoneExt":11,"email":11},"David Zlotnick, MD",{"facility":147,"status":55,"city":148,"state":149,"zip":150,"country":59,"countryCode":60,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"Summa Akron","Akron","Ohio","44304",{"type":62,"coordinates":152},[153,154],-81.51901,41.08144,{"lat":154,"lon":153},[157],{"name":158,"role":45,"phone":11,"phoneExt":11,"email":11},"Mark Rea, MD",{"facility":160,"status":55,"city":161,"state":162,"zip":163,"country":59,"countryCode":60,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"UPHS Penn Health System","Philadelphia","Pennsylvania","19104",{"type":62,"coordinates":165},[166,167],-75.16362,39.95238,{"lat":167,"lon":166},[170,172],{"name":171,"role":45,"phone":11,"phoneExt":11,"email":11},"Taisei Kobayashi, MD",{"name":173,"role":45,"phone":11,"phoneExt":11,"email":11},"Russell Rosenberg, MD",{"facility":175,"status":55,"city":176,"state":162,"zip":177,"country":59,"countryCode":60,"cosmosGeoPoint":178,"geoPoint":182,"contacts":183},"Allegheny General Hospital","Pittsburgh","15212",{"type":62,"coordinates":179},[180,181],-79.99589,40.44062,{"lat":181,"lon":180},[184],{"name":185,"role":45,"phone":11,"phoneExt":11,"email":11},"Mithun Chakravarthy, MD",{"facility":187,"status":55,"city":188,"state":189,"zip":190,"country":59,"countryCode":60,"cosmosGeoPoint":191,"geoPoint":195,"contacts":196},"HCA Tristar\u002FCentennial","Nashville","Tennessee","37203",{"type":62,"coordinates":192},[193,194],-86.78444,36.16589,{"lat":194,"lon":193},[197],{"name":198,"role":45,"phone":11,"phoneExt":11,"email":11},"Samuel Horr, MD",{"facility":200,"status":55,"city":201,"state":202,"zip":203,"country":59,"countryCode":60,"cosmosGeoPoint":204,"geoPoint":208,"contacts":209},"HCA Medical City Heart & Spine","Dallas","Texas","75039",{"type":62,"coordinates":205},[206,207],-96.80667,32.78306,{"lat":207,"lon":206},[210],{"name":211,"role":45,"phone":11,"phoneExt":11,"email":11},"Srinivas Yallapragada, MD",{"facility":213,"status":55,"city":214,"state":202,"zip":215,"country":59,"countryCode":60,"cosmosGeoPoint":216,"geoPoint":220,"contacts":221},"HCA Methodist Health San Antonio","San Antonio","78229",{"type":62,"coordinates":217},[218,219],-98.49363,29.42412,{"lat":219,"lon":218},[222],{"name":223,"role":45,"phone":11,"phoneExt":11,"email":11},"Chandra Kunavarapu, MD",{"facility":225,"status":55,"city":226,"state":11,"zip":227,"country":228,"countryCode":229,"cosmosGeoPoint":230,"geoPoint":234,"contacts":235},"Besançon University Hospital","Besançon","25030","France","FR",{"type":62,"coordinates":231},[232,233],6.01815,47.24878,{"lat":233,"lon":232},[236],{"name":237,"role":45,"phone":11,"phoneExt":11,"email":11},"Nicolas Meneveau, MD, PhD",{"facility":239,"status":55,"city":240,"state":11,"zip":11,"country":228,"countryCode":229,"cosmosGeoPoint":241,"geoPoint":245,"contacts":246},"Hopital Arnaud de Villeneuve, Montpellier","Montpellier",{"type":62,"coordinates":242},[243,244],3.87635,43.61093,{"lat":244,"lon":243},[247],{"name":248,"role":45,"phone":11,"phoneExt":11,"email":11},"Francoise Roubille, MD",{"facility":250,"status":55,"city":251,"state":11,"zip":11,"country":228,"countryCode":229,"cosmosGeoPoint":252,"geoPoint":256,"contacts":257},"CHU Nîmes Caremeau","Nîmes",{"type":62,"coordinates":253},[254,255],4.35788,43.83665,{"lat":255,"lon":254},[258],{"name":259,"role":45,"phone":11,"phoneExt":11,"email":11},"Benoit Lattuca, MD, PhD",{"facility":261,"status":55,"city":262,"state":11,"zip":11,"country":228,"countryCode":229,"cosmosGeoPoint":263,"geoPoint":267,"contacts":268},"Hôpital Européen Georges-Pompidou, Paris","Paris",{"type":62,"coordinates":264},[265,266],2.3488,48.85341,{"lat":266,"lon":265},[269],{"name":270,"role":45,"phone":11,"phoneExt":11,"email":11},"Olivier Sanchez, MD, PhD",{"facility":272,"status":55,"city":273,"state":11,"zip":11,"country":274,"countryCode":275,"cosmosGeoPoint":276,"geoPoint":280,"contacts":281},"Klinikum Chemnitz","Chemnitz","Germany","DE",{"type":62,"coordinates":277},[278,279],12.92922,50.8357,{"lat":279,"lon":278},[282],{"name":283,"role":45,"phone":11,"phoneExt":11,"email":11},"Karim Ibrahim, MD",{"facility":285,"status":55,"city":286,"state":11,"zip":11,"country":274,"countryCode":275,"cosmosGeoPoint":287,"geoPoint":291,"contacts":292},"Universitätsklinikum Carl Gustav Carus an der TU Dresden","Dresden",{"type":62,"coordinates":288},[289,290],13.73832,51.05089,{"lat":290,"lon":289},[293],{"name":294,"role":45,"phone":11,"phoneExt":11,"email":11},"Ralf-Thorsten Hoffmann, MD",{"facility":296,"status":55,"city":297,"state":11,"zip":298,"country":274,"countryCode":275,"cosmosGeoPoint":299,"geoPoint":303,"contacts":304},"Universitätsmedizin Mainz","Mainz","55131",{"type":62,"coordinates":300},[301,302],8.28008,49.98185,{"lat":302,"lon":301},[305],{"name":306,"role":45,"phone":11,"phoneExt":11,"email":11},"Stavros Konstantinides, MD, PhD",{"facility":308,"status":55,"city":309,"state":11,"zip":11,"country":274,"countryCode":275,"cosmosGeoPoint":310,"geoPoint":314,"contacts":315},"Munich LMU","München",{"type":62,"coordinates":311},[312,313],13.31243,51.60698,{"lat":313,"lon":312},[316],{"name":317,"role":45,"phone":11,"phoneExt":11,"email":11},"Konstantin Stark, MD",{"facility":319,"status":55,"city":320,"state":11,"zip":11,"country":274,"countryCode":275,"cosmosGeoPoint":321,"geoPoint":325,"contacts":326},"Universitätsklinik Regensburg","Regensburg",{"type":62,"coordinates":322},[323,324],12.10161,49.01513,{"lat":324,"lon":323},[327],{"name":328,"role":45,"phone":11,"phoneExt":11,"email":11},"Stefan Stadler, MD",{"facility":330,"status":55,"city":331,"state":11,"zip":11,"country":332,"countryCode":333,"cosmosGeoPoint":334,"geoPoint":338,"contacts":339},"Hospital Universitari Vall d'Hebron, Barcelona","Barcelona","Spain","ES",{"type":62,"coordinates":335},[336,337],2.15899,41.38879,{"lat":337,"lon":336},[340],{"name":341,"role":45,"phone":11,"phoneExt":11,"email":11},"Juan Carlos Ruiz, MD, PhD",{"facility":343,"status":55,"city":344,"state":11,"zip":345,"country":332,"countryCode":333,"cosmosGeoPoint":346,"geoPoint":350,"contacts":351},"Hospital Universitario La Paz Madrid","Madrid","28046",{"type":62,"coordinates":347},[348,349],-3.70256,40.4165,{"lat":349,"lon":348},[352],{"name":353,"role":45,"phone":11,"phoneExt":11,"email":11},"Raul Moreno, MD, PhD",{"facility":355,"status":55,"city":356,"state":11,"zip":357,"country":358,"countryCode":359,"cosmosGeoPoint":360,"geoPoint":364,"contacts":365},"University Hospital Basel","Basel","4031","Switzerland","CH",{"type":62,"coordinates":361},[362,363],7.57327,47.55839,{"lat":363,"lon":362},[366],{"name":367,"role":45,"phone":11,"phoneExt":11,"email":11},"Gregor Leibundgut, MD",{"facility":369,"status":55,"city":370,"state":11,"zip":11,"country":371,"countryCode":372,"cosmosGeoPoint":373,"geoPoint":377,"contacts":378},"Royal Free Hospital London","London","United Kingdom","UK",{"type":62,"coordinates":374},[375,376],-0.12574,51.50853,{"lat":376,"lon":375},[379],{"name":380,"role":45,"phone":11,"phoneExt":11,"email":11},"Tushar Kotecha, MBChB, PhD",{"type":382,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100561320","the-persevere-study-100561320",false,"NCT06588634","The PERSEVERE Study","Inclusion Criteria:\n\n1. Age at enrollment ≥18 years\n2. Objective evidence of a proximal filling defect in at least one main or lobar pulmonary artery\n3. High-risk class of acute PE\n4. RV dysfunction, as defined RV\u002FLV ratio ≥1.0\n5. Willing and able to provide informed consent, or if unable, through a Legal Authorized Representative, with permitting research without prior consent as a third option (for Europe and UK sites only), provided compliance with IRB\u002FEC approvals and adherence to regulatory, ethical and national standards\n\nExclusion Criteria:\n\n1. Prolonged cardiac arrest with loss of consciousness associated with neurological deficit.\n2. Imaging evidence or other evidence that suggests, in the opinion of the Investigator, the patient is not appropriate for catheter-based intervention\n3. Known pre-existing CTEPH, or CT signs of chronic PE that may point to pre-existing CTEPH\n4. Recent stroke (\\\u003C14 days)\n5. Recent cranial or spinal surgery (\\\u003C14 days)\n6. Life-threatening active bleeding or hemorrhage into a critical area\n7. Known intracranial tumor\n8. End-stage medical condition with life expectancy \\\u003C3 months (irrespective of the severity of acute PE), as determined by the Investigator\n9. Known sensitivity to radiographic contrast agents that, in the Investigator's opinion, cannot be adequately pre-treated\n10. Inability to anticoagulate the patient, or known to have heparin-induced thrombocytopenia (HIT)\n11. Current participation in another drug or device study that may interfere with the conduct of this trial\n12. Ventricular arrhythmias refractory to treatment at the time of enrollment\n13. Subject has any condition for which, in the opinion of the investigator, participation would not be in the best interest of the subject (e.g., compromise the well-being or that could prevent, limit, or confound the protocol-specified assessments), including a contraindication to use of FlowTriever System per local approved labeling\n14. Subject is part of a vulnerable population (e.g., currently pregnant, breastfeeding or incarcerated) per local definitions\n15. Subject was previously enrolled in this study\n16. Subject has received prior thrombolytic (systemic or catheter-directed) therapy for any reason or thrombectomy (surgical or catheter-based) therapy for index PE, within 30 days prior to randomization","ALL","18 Years",{"count":392,"type":393},200,"ESTIMATED","INTERVENTIONAL",[396],"NA","Randomized Controlled Trial of High-Risk Pulmonary Embolism Comparing FlowTriever System vs. Standard of Care",[399,400],"Pulmonary Embolism","Pulmonary Thromboembolism",[402,399,9,403,404,405],"PE","CDT","Catheter Directed Thrombolysis","Anticoagulation","2026-06-02",{"date":408,"type":409},"2026-06-04","ACTUAL",{"date":411,"type":409},"2024-12-16",{"date":413,"type":393},"2028-02",{"name":5,"class":6},26]