[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100389543":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":32,"centralContacts":37,"locations":46,"responsibleParty":65,"collaborators":68,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":10,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":10,"studyType":85,"phases":10,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Beth Israel Deaconess Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Surgical Participants",null,"Individuals undergoing abdominal surgery or radiologically-guided biopsies for clinical indications will be recruited prior to the planned procedures.",[13,14,15],"Procedure: Fat biopsy","Diagnostic Test: Blood sampling","Genetic: Blood sample for DNA analysis",[17,22,27],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"PROCEDURE","Fat biopsy","The fat biopsy is performed during a scheduled procedure at the Beth Israel Deaconess Medical Center (BIDMC). Routine preoperative procedures will be followed, including local anesthesia (numbing a particular region of the body) or general anesthesia (being put to sleep).\n\nAdipose tissue will be sampled from different depots depending on the procedure. For example, the surgeon will collect adipose tissue from the neck and supraclavicular depots from cervical spine, thyroid, and parathyroid procedures; perinephric fat from adrenalectomies, omental fat from abdominal procedures, and paraspinal fat from lumbar spine procedures. Up to 5 pieces of fat tissue weighing about three to six grams will be removed. All other aspects of the surgical procedure will proceed as planned. Samples will be prepared for subsequent laboratory analysis.",[9],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"DIAGNOSTIC_TEST","Blood sampling","A blood sample will be collected in the fasting state either during preoperative testing or in the preoperative area on the day of planned procedure for measurement of adipose functional markers (leptin, adiponectin) and insulin resistance (insulin, C-peptide), and measures of glycemia (glucose, hemoglobin A1c).",[9],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":10},"GENETIC","Blood sample for DNA analysis","Targeted resequencing of DNA to identify variants associated with adipose phenotypes will be performed.",[9],[33],{"name":34,"affiliation":35,"role":36},"Mary Elizabeth Patti, MD","Joslin Diabetes Center","PRINCIPAL_INVESTIGATOR",[38,42],{"name":34,"role":39,"phone":40,"phoneExt":10,"email":41},"CONTACT","6173092635","MaryElizabeth.Patti@joslin.harvard.edu",{"name":43,"role":39,"phone":44,"phoneExt":10,"email":45},"Amanda L Sheehan, MSN","6173092695","amanda.sheehan@joslin.harvard.edu",[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Boston","Massachusetts","02215","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-71.05977,42.35843,{"lat":58,"lon":57},[61],{"name":62,"role":39,"phone":63,"phoneExt":10,"email":64},"Andrew P White, MD","6177549000","apwhite@bidmc.harvard.edu",{"type":36,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Mary Elizabeth Patti","Associate Professor of Medicine",[69,70],{"name":35,"class":6},{"name":71,"class":6},"Chan Zuckerberg Initiative","100389543","the-physiology-of-human-brown-adipose-tissue-100389543",false,"NCT04352244","The Physiology of Human Brown Adipose Tissue","Inclusion criteria:\n\n1\\. Healthy participants between age 18 and 75 years undergoing planned clinically indicated procedure at BIDMC.\n\nExclusion Criteria:\n\n1. Body mass index (BMI) greater than or equal to 40 kg\u002Fm2\n2. History of any local or systemic infectious disease with fever or requiring antibiotic within four weeks of drug administration;\n3. Diabetes, either previously diagnosed or hemoglobin A1c greater than or equal to 6.5%\n4. Use of oral or parenteral corticosteroids (epidural permitted) or other medication known to cause insulin resistance in the previous 6 weeks.\n5. Willingness to provide informed consent and follow study procedures, including attending scheduled visits.\n6. Chronic kidney disease stage 4 or 5 (including end-stage renal disease);\n7. Hepatic disease, including serum alanine aminotransferase (ALT) or aspartate transaminase (AST) greater than or equal to 3 times the upper limit of normal; hepatic synthetic insufficiency as defined as serum albumin \\\u003C 3.0 g\u002FdL; or serum bilirubin \\> 2.0;\n8. Active malignancy (except squamous or basal cell carcinoma of skin)\n9. Bleeding disorder, treatment with anticoagulants (if not discontinued prior to surgery), or platelet count \\\u003C50,000;\n10. Current addiction to alcohol or substances of abuse;\n11. Mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation;\n12. Use of an investigational drug within 30 days prior to screening.\n13. There will be no involvement of special vulnerable populations such as fetuses, neonates, pregnant women, children, prisoners, institutionalized or incarcerated individuals, or others who may be considered vulnerable populations.\n14. Because the goal is to study adult human brown adipose tissue, children are not eligible to participate.",true,"ALL","18 Years","75 Years",{"count":83,"type":84},40,"ESTIMATED","OBSERVATIONAL","Brown fat is a type of fat, found in both children and adults, which can produce heat and regulate the body's metabolism and energy use. White fat is the more common type of fat which is used to store extra calories. Understanding more about differences between brown and white fat may allow us to develop new approaches to improve the body's metabolism.",[88,89,90],"Adipose Tissue, Brown","Adipose Tissue","Obesity",[92],"Human Cell Atlas","2025-10-30",{"date":95,"type":96},"2025-10-31","ACTUAL",{"date":98,"type":96},"2020-03-05",{"date":100,"type":84},"2027-06-30",{"name":5,"class":6},1]