[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623007":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":26,"locations":10,"responsibleParty":34,"collaborators":10,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":42,"eligibilityCriteria":43,"healthyVolunteers":38,"sex":44,"minAge":45,"maxAge":10,"enrollmentInfo":46,"targetDuration":10,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":54,"overallStatus":61,"whyStopped":10,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":10},{"fullName":5,"class":6},"Fondazione Ricerca e Innovazione Cardiovascolare ETS","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Aggressive Lesion Preparation",null,"Patients who underwent lesion preparation using cutting\u002FWolverine balloons, scoring balloons (any brand), and\u002For OPN balloons prior to DCB angioplasty for ISR.",{"label":13,"type":10,"description":14,"interventionNames":10},"Standard Lesion Preparation","Patients who underwent lesion preparation using semi-compliant balloons and\u002For non-compliant balloons prior to DCB angioplasty for ISR.",[16,20,23],{"name":17,"affiliation":18,"role":19},"Bharat Khialani, MD","Tan Tock Seng Hospital, National Healthcare Group, Singapore","PRINCIPAL_INVESTIGATOR",{"name":21,"affiliation":22,"role":19},"Filippo Luca Gurgoglione, MD, PhD","Department of Cardiology, Parma University Hospital, Parma, Italy",{"name":24,"affiliation":5,"role":25},"Bernardo Cortese, MD","STUDY_CHAIR",[27,31],{"name":21,"role":28,"phone":29,"phoneExt":10,"email":30},"CONTACT","+393312048150","filippolucagurgoglione@gmail.com",{"name":32,"role":28,"phone":10,"phoneExt":10,"email":33},"Beatrice Barbano","segreteria@fondazioneric.org",{"type":35,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100623007","the-piccoleto-xi-a-prep-study-100623007",false,"NCT07391033","The PICCOLETO XI A-PREP Study","Impact of Lesion PREParation With Modifying Balloons During Drug-coated Balloon (DCB) Angioplasty for In-stent Restenosis (ISR) - PICCOLETO XI A-PREP Study","PICCOLETO-XI","Inclusion Criteria:\n\n* Adult patients ≥18 years of age\n* Patients who underwent DCB angioplasty for in-stent restenosis\n\nExclusion Criteria:\n\n\\- Lack of clinical outcome assessment","ALL","18 Years",{"count":47,"type":48},500,"ESTIMATED","OBSERVATIONAL","To compare the angiographic and clinical outcomes of aggressive versus standard balloon preparation during drug-coated balloon (DCB) angioplasty for in-stent restenosis (ISR). The study will evaluate whether more aggressive lesion preparation with cutting\u002Fscoring\u002FOPN balloons improves outcomes compared to standard preparation with semi-compliant or non-compliant balloons.",[52,53],"In-Stent Coronary Artery Restenosis","Coronary Artery Disease",[55,56,57,58,59,60],"Drug-Coated Balloon","In-Stent Restenosis","Lesion Preparation","Cutting Balloon","Scoring Balloon","Percutaneous Coronary Intervention","NOT_YET_RECRUITING","2026-01-29",{"date":64,"type":65},"2026-02-05","ACTUAL",{"date":67,"type":48},"2026-06-01",{"date":69,"type":48},"2028-06-01",{"name":5,"class":6}]