[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627584":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":30,"centralContacts":34,"locations":44,"responsibleParty":66,"collaborators":10,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":10,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":10,"enrollmentInfo":77,"targetDuration":10,"studyType":80,"phases":10,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":89,"whyStopped":10,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Manchester University NHS Foundation Trust","OTHER_GOV",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Advanced Chronic Kindney Disease expected to need dialysis in the next 6 months",null,"As per study description: individuals with progressive advanced chronic kidney disease. Interventions of interest include iohexol injection and 4x finger prick sample collection; clinical review; questionnaire. Routine blood and urine tests are also of interest.",[13],"Diagnostic Test: Iohexol Inj 300 MG\u002FML Diagnostic aid\u002Fagent used to measure glomerular filtration rate (GFR)",{"label":15,"type":10,"description":16,"interventionNames":17},"End stage kidney disease established on peritoneal dialysis with >100ml \u002F 24hours urine output","As per study description: individuals with established end stage chronic kidney disease undergoing peritoneal dialysis. Interventions of interest include iohexol injection and 4x finger prick sample collection; clinical review; questionnaire. Routine blood, urine and peritoneal fluid tests are also of interest.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"End stage kidney disease established on haemodialysis with >100ml \u002F 24hour urine output","As per study description: individuals with established end stage chronic kidney disease undergoing haemodialysis. Interventions of interest include iohexol injection and 4x finger prick sample collection; clinical review; questionnaire. Routine blood and urine tests are also of interest.",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DIAGNOSTIC_TEST","Iohexol Inj 300 MG\u002FML Diagnostic aid\u002Fagent used to measure glomerular filtration rate (GFR)","Injection of 3235mg iohexol (equivalent to 5ml Omnipaque 300) followed by serial dried blood spot testing over 24 hours to be measured for iohexol concentration and used to calculate clearance.",[9,19,15],[29],"Omnipaque 300",[31],{"name":32,"affiliation":5,"role":33},"Thomas Lindsay","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":10,"email":39},"Thomas Lindsay, MBChB","CONTACT","+44 161 276 4370","thomas.lindsay@mft.nhs.uk",{"name":41,"role":37,"phone":42,"phoneExt":10,"email":43},"Leonard Ebah, MD\u002FFRCP\u002FPhD","+44 161 276 6748","Leonard.ebah@mft.nhs.uk",[45],{"facility":46,"status":10,"city":47,"state":10,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Manchester Royal infirmary","Manchester","M13 9WL","United Kingdom","UK",{"type":52,"coordinates":53},"Point",[54,55],-2.23743,53.48095,{"lat":55,"lon":54},[58,60,61,64],{"name":32,"role":37,"phone":59,"phoneExt":10,"email":39},"0161 276 4370",{"name":32,"role":33,"phone":10,"phoneExt":10,"email":10},{"name":62,"role":63,"phone":10,"phoneExt":10,"email":10},"Leoard Ebah","SUB_INVESTIGATOR",{"name":65,"role":63,"phone":10,"phoneExt":10,"email":10},"Sandip Mitra",{"type":67,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100627584","the-practicality-and-utility-of-measured-vs-estimated-gfr-in-adckd-100627584",false,"NCT07450534","The Practicality and Utility of Measured vs Estimated GFR in adCKD","The Practicality & Utility of Estimated vs Measured Renal Function in Advanced Kidney Disease, Whether Treated With Dialysis or Not: Can Better Techniques be Used to Predict the Onset of the Uraemic Syndrome and Guide Dialysis Requirements","Inclusion Criteria:\n\n* Adults (18 year s or older)\n* Able to give informed consent\n* Progressive chronic kidney disease predicted to start renal replacement therapy in the next 6 months OR established on dialysis (either haemodialysis or peritoneal) with residual renal function (Urine output \\>100ml\u002Fday)\n\nExclusion Criteria:\n\n* Under 18 years\n* Known allergy to iodinated contrast media\n* Unable to perform fingerprick blood testing\n* Unable to comply with urine collection\n* Unable or unwilling to give informed consent in English\n* Acute kidney injury expected to recover renal function\n* Pre-dialysis and planned renal transplant within 1 month\n* Pregnant or breast feeding\n* Significant fluid overload (significant peripheral oedema or ascites AND \\>10kg above estimated dry weight)","ALL","18 Years",{"count":78,"type":79},150,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to assess if new ways of measuring kidney function can better predict when individuals will become symptomatic due to kidney failure, and whether residual kidney function can be accurately measured in those already on dialysis.\n\nThe main questions the study is trying to answer is whether measuring kidney function by clearance of iohexol is comparable to the current standard of care methods.\n\nIn addition to routine care, participants will:\n\n* undergo a brief clinical assessment\n* be given an injection of iohexol and asked to perform 4 finger prick blood tests over 24 hours, recording the time of each sample. Samples will be returned in person or posted back\n* be asked to complete a questionnaire on their experience",[83,84],"Chronic Kidney Disease (Stages 4 and 5)","Chronic Kidney Disease 5D",[86,87,88],"mGFR","iohexol","Residual Kidney Function","NOT_YET_RECRUITING","2026-02-27",{"date":92,"type":93},"2026-03-04","ACTUAL",{"date":95,"type":79},"2026-02",{"date":97,"type":79},"2027-02",{"name":5,"class":6},1]