[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606520":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":24,"locations":30,"responsibleParty":48,"collaborators":18,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":18,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":18,"enrollmentInfo":59,"targetDuration":18,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":71,"overallStatus":32,"whyStopped":18,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"The First Hospital of Jilin University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Enteral nutrition reduction group","EXPERIMENTAL","Before the prone position, the gastric contents are aspirated with a syringe, and the dose of enteral nutrition reduction is determined based on the different amounts of gastric residue. If the residual volume in the stomach is less than 200ml, the enteral nutrition intake will be reduced by one third. Gastric residual volume 200-500ml: Reduce enteral nutrition by half. If the residual gastric volume is greater than 500ml: Stop enteral nutrition and consider post-pyloric feeding",[13],"Procedure: Enteral nutrition is reduced before the prone position",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional feeding group","NO_INTERVENTION","Do not reduce the feeding speed before the prone position and continue to feed at the original speed",null,[20],{"type":21,"name":22,"description":11,"armGroupLabels":23,"otherNames":18},"PROCEDURE","Enteral nutrition is reduced before the prone position",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"Youquan Wang, M.D.","CONTACT","+8615584299391","wangyq20@mails.jlu.edu.cn",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Changchun","Jilin","130021","China","CN",{"type":39,"coordinates":40},"Point",[41,42],125.32278,43.88,{"lat":42,"lon":41},[45],{"name":46,"role":27,"phone":47,"phoneExt":18,"email":29},"youquan Wang","15584299391",{"type":49,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100606520","the-pre-vail-study-100606520",false,"NCT07176624","The PRE-VAIL Study","The Effect of Reducing Enteral Nutrition Before Prone Positioning on Clinical Outcomes in Mechanically Ventilated ARDS Patients: A Multicenter Randomized Controlled Trial (The PRE-VAIL Study)","Inclusion Criteria:\n\n* Age ≥18 years old\n* Within 24 hours of admission to the ICU, one or more organ systems have failed (the Sequential Organ Failure Assessment (SOFA) score of any single organ system is ≥2)\n* Meet the diagnostic criteria for moderate\u002Fsevere ARDS (even after optimizing the ventilation Settings, the oxygenation index is still \\\u003C 150mmHg and PEEP is still ≥5 cm H2O)\n* It is expected to stay in the ICU for more than 48 hours\n\nExclusion Criteria:\n\n* There are contraindications for the prone position\n* There are contraindications for EN, preventing the initiation of early EN (≤48 hours)\n* Expected to die within 48 hours\n* Pregnancy","ALL","18 Years",{"count":60,"type":61},259,"ESTIMATED","INTERVENTIONAL",[64],"NA","During the prone position, there may be an increase in intragastric pressure. The investigators focus on a scientific question: Whether reducing enteral nutrition before the prone position will benefit patients with severe mechanically ventilated acute respiratory distress syndrome (ARDS).\n\nThe experimental group had the enteral nutrition dose reduced before the prone position, while the control group did not have the enteral nutrition dose reduced",[67,68,69,70],"ARDS (Moderate or Severe)","Prone Position","Enteral Nutrition Feeding","Intensive Care Unit (ICU) Admission",[72,73,74,75,76,77],"ARDS","Mechanical ventilation","Prone position","Enteral nutrition","Gastric retention","Clinical outcome","2026-02-05",{"date":80,"type":81},"2026-02-09","ACTUAL",{"date":83,"type":81},"2025-09-14",{"date":85,"type":61},"2028-02-20",{"name":5,"class":6},1]