[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100507318":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":47,"centralContacts":51,"locations":56,"responsibleParty":90,"collaborators":92,"id":95,"slug":96,"hasResults":97,"nctId":98,"briefTitle":99,"officialTitle":99,"acronym":39,"eligibilityCriteria":100,"healthyVolunteers":97,"sex":101,"minAge":102,"maxAge":103,"enrollmentInfo":104,"targetDuration":39,"studyType":107,"phases":108,"briefSummary":110,"conditions":111,"keywords":113,"overallStatus":58,"whyStopped":39,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":128},{"fullName":5,"class":6},"Westlake University","OTHER",[8,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Plant-based diet","EXPERIMENTAL","Participants in this arm will be recommended to consume more fiber-rich foods, including whole grains, fruits, legumes and vegetables; to moderate their intake of fish, eggs and dairy products; and to avoid other animal products. All participants are instructed not to modify their exercise habits during the intervention period.",[13,14,15,16],"Other: White bread","Other: Whole wheat bread","Behavioral: Plant-based diet","Other: Follow-up visit every 1-2 years",{"label":18,"type":10,"description":19,"interventionNames":20},"Conventional diabetic diet","Participants in this arm will be recommended to have a diet following 2023 Chinese Diabetes Society guidelines. All participants are instructed not to modify their exercise habits during the intervention period.",[13,14,21,16],"Other: Conventional diabetic diet",[23,29,35,40,43],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"White bread","After wearing CGM on Day 1, participants will be provided with white bread (76-77g) and milk (250mL) for breakfast on Day 3, Day 4, Day 7, Day 8, Day 10, Day 12.",[18,9],[28],"Breakfast A",{"type":6,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Whole wheat bread","After wearing CGM on Day 1, participants will be provided with wheat bread (85-86g) and milk (250mL) for breakfast on Day 2, Day 5, Day 6, Day 9, Day 11, Day 13.",[18,9],[34],"Breakfast B",{"type":36,"name":9,"description":37,"armGroupLabels":38,"otherNames":39},"BEHAVIORAL","After wearing CGM on Day 1, participants will be asked to follow the plant-based diet in next 30 days.",[9],null,{"type":6,"name":18,"description":41,"armGroupLabels":42,"otherNames":39},"Volunteers will be asked to have a diet following 2023 Chinese Diabetes Society guidelines in next 30 days.",[18],{"type":6,"name":44,"description":45,"armGroupLabels":46,"otherNames":39},"Follow-up visit every 1-2 years","Participants will be visited every 1-2 years. At each visit, face-to-face interviews, specimen collection, anthropometric measurements, ultrasonography evaluation, laboratory tests, and multi-omics data will be conducted.",[18,9],[48],{"name":49,"affiliation":5,"role":50},"Ju-Sheng Zheng, PhD","PRINCIPAL_INVESTIGATOR",[52],{"name":49,"role":53,"phone":54,"phoneExt":39,"email":55},"CONTACT","86-0571-88112056","zhengjusheng@westlake.edu.cn",[57,78],{"facility":5,"status":58,"city":59,"state":60,"zip":61,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"RECRUITING","Hangzhou","Zhejiang","310030","China","CN",{"type":65,"coordinates":66},"Point",[67,68],120.16142,30.29365,{"lat":68,"lon":67},[71,74,77],{"name":72,"role":53,"phone":54,"phoneExt":39,"email":73},"Zelei Miao, PhD","miaozelei@westlake.edu.cn",{"name":75,"role":53,"phone":54,"phoneExt":39,"email":76},"Hang He, Master","hehang@westlake.edu.cn",{"name":49,"role":50,"phone":39,"phoneExt":39,"email":39},{"facility":79,"status":58,"city":59,"state":60,"zip":80,"country":62,"countryCode":63,"cosmosGeoPoint":81,"geoPoint":83,"contacts":84},"Hangzhou Third People's Hospital","310058",{"type":65,"coordinates":82},[67,68],{"lat":68,"lon":67},[85,87,89],{"name":86,"role":53,"phone":39,"phoneExt":39,"email":39},"Peng Li, Master",{"name":88,"role":53,"phone":39,"phoneExt":39,"email":39},"Yu Chen, Master",{"name":86,"role":50,"phone":39,"phoneExt":39,"email":39},{"type":91,"investigatorFullName":39,"investigatorTitle":39,"investigatorAffiliation":39,"oldNameTitle":39,"oldOrganization":39},"SPONSOR",[93],{"name":94,"class":6},"The Third People's Hospital of Hangzhou","100507318","the-precision-t2d-study-precision-nutrition-study-for-type-2-diabetes-100507318",false,"NCT05885828","The PRECISION-T2D Study: Precision Nutrition Study for Type 2 Diabetes","Inclusion Criteria:\n\n* Diagnosed with type 2 diabetes;\n* Living in Hangzhou for at least five years;\n* Have the willingness or ability to complete the intervention and sample collection\n\nExclusion Criteria:\n\n* Mental and physical disability;\n* Already is a vegetarian;\n* Cancer and serious complications from type 2 diabetes, such as renal failure;\n* Using insulin for more than 5 years;\n* Unstable medical\u002Fmedication status;\n* Current alcohol or drug abuse;\n* Taking antibiotics in the last three months","ALL","35 Years","75 Years",{"count":105,"type":106},200,"ESTIMATED","INTERVENTIONAL",[109],"NA","Food plays a crucial role in determining blood glucose levels, especially in people with type 2 diabetes. Precision nutrition, which involves individually tailored dietary interventions, can be a powerful tool in managing blood glucose levels in people with type 2 diabetes. Previous studies found that changes in gut microbiota resulted from the dietary intervention, such as plant-based diet, might subsequently lead to different glycemic responses, and then different health outcomes.\n\nIn this study, the investigators will characterize the blood glucose dynamics and gut microbiota of individuals with type 2 diabetes. They aim to assess the influence of plant-based diet on gut microbiota; they will also investigate the influence of gut microbiota on glycemic responses. Additionally, a series of individual N-of-1 trails will be integrated to compare the effects of a white bread breakfast and a whole wheat bread breakfast on glucose metabolism at the individual level.",[112],"Type 2 Diabetes",[114,115,116,117,118],"N-of-1","plant-based diet","precision nutrition","continuous glucose monitoring","type 2 diabetes","2025-06-10",{"date":121,"type":122},"2025-06-13","ACTUAL",{"date":124,"type":122},"2023-07-17",{"date":126,"type":106},"2033-12-01",{"name":5,"class":6},2]