[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545463":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":30,"responsibleParty":112,"collaborators":114,"id":124,"slug":125,"hasResults":126,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":126,"sex":132,"minAge":133,"maxAge":134,"enrollmentInfo":135,"targetDuration":10,"studyType":138,"phases":10,"briefSummary":139,"conditions":140,"keywords":143,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":158},{"fullName":5,"class":6},"University of Campania Luigi Vanvitelli","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Babies with unilateral UPJO",null,"Children aged 0-5 years with unilateral UPJO. Unilateral UPJO will be defined as an hydronephrosis needing of surgical correction on the basis of at least 2 of the following criteria: APDP ≥ 30 mm, SRF less than 40% at the Mag3S, SRF with delta \\> 10% at follow-up Mag3S compared with the first Mag3S, delayed wash-out following diuretic administration, progressive increase of the APDP at follow-up kidney ultrasounds, 4th degree hydronephrosis.",[13],"Diagnostic Test: Identification of Diagnostic Biomarkers",{"label":15,"type":10,"description":16,"interventionNames":17},"Controls of babies with unilateral UPJO","Children aged 0-5 years needing of surgical correction for hernia, hydrocele, phimosis or cryptorchidism.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","Identification of Diagnostic Biomarkers","Urinary single-cell and EVs screening to stage the intrarenal injury and repair processes in UPJO babies and identification of the whole blood gene expression profiling of babies with unilateral UPJO. Data deriving from patients with unilateral UPJO will be compared with data deriving from controls.",[9,15],[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Pierluigi Marzuillo, MD PhD","CONTACT","00390815665344","pierluigi.marzuillo@unicampania.it",[31,65,74,87,101],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Univeristà degli Studi della Campania Luigi Vanvitelli","RECRUITING","Naples","Campania","80138","Italy","IT",{"type":40,"coordinates":41},"Point",[42,43],14.26811,40.85216,{"lat":43,"lon":42},[46,48,50,52,54,57,59,61,63],{"name":47,"role":27,"phone":10,"phoneExt":10,"email":10},"Pierluigi Marzuillo",{"name":47,"role":49,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"name":51,"role":49,"phone":10,"phoneExt":10,"email":10},"Paolo Montaldo",{"name":53,"role":49,"phone":10,"phoneExt":10,"email":10},"Carmine Noviello",{"name":55,"role":56,"phone":10,"phoneExt":10,"email":10},"Alfonso Papparella","SUB_INVESTIGATOR",{"name":58,"role":56,"phone":10,"phoneExt":10,"email":10},"Stefano Guarino",{"name":60,"role":56,"phone":10,"phoneExt":10,"email":10},"Anna Di Sessa",{"name":62,"role":56,"phone":10,"phoneExt":10,"email":10},"Grazia Cirillo",{"name":64,"role":56,"phone":10,"phoneExt":10,"email":10},"Giusy Capasso",{"facility":66,"status":67,"city":68,"state":10,"zip":10,"country":37,"countryCode":38,"cosmosGeoPoint":69,"geoPoint":73,"contacts":10},"Department of Clinical Sciences and Community Health, University of Milano","ACTIVE_NOT_RECRUITING","Milan",{"type":40,"coordinates":70},[71,72],9.18951,45.46427,{"lat":72,"lon":71},{"facility":75,"status":33,"city":68,"state":10,"zip":10,"country":37,"countryCode":38,"cosmosGeoPoint":76,"geoPoint":78,"contacts":79},"Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico",{"type":40,"coordinates":77},[71,72],{"lat":72,"lon":71},[80,82,83,85],{"name":81,"role":27,"phone":10,"phoneExt":10,"email":10},"Giovanni Montini",{"name":81,"role":49,"phone":10,"phoneExt":10,"email":10},{"name":84,"role":49,"phone":10,"phoneExt":10,"email":10},"Alfredo Berrettini",{"name":86,"role":56,"phone":10,"phoneExt":10,"email":10},"Michele Gnech",{"facility":88,"status":33,"city":89,"state":10,"zip":10,"country":37,"countryCode":38,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"Obstetrics and Gynecology Unit, University of Modena and Reggio Emilia","Modena",{"type":40,"coordinates":91},[92,93],10.92539,44.64783,{"lat":93,"lon":92},[96,98,99],{"name":97,"role":27,"phone":10,"phoneExt":10,"email":10},"Giovanni Grandi",{"name":97,"role":49,"phone":10,"phoneExt":10,"email":10},{"name":100,"role":56,"phone":10,"phoneExt":10,"email":10},"Stefano Puliatti",{"facility":102,"status":33,"city":34,"state":10,"zip":10,"country":37,"countryCode":38,"cosmosGeoPoint":103,"geoPoint":105,"contacts":106},"AORN Santobono-Pausilipon",{"type":40,"coordinates":104},[42,43],{"lat":43,"lon":42},[107,109,110],{"name":108,"role":27,"phone":10,"phoneExt":10,"email":10},"Giovanni Di Iorio",{"name":108,"role":49,"phone":10,"phoneExt":10,"email":10},{"name":111,"role":56,"phone":10,"phoneExt":10,"email":10},"Agnese Roberti",{"type":49,"investigatorFullName":47,"investigatorTitle":113,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Associate Professor",[115,117,120,122],{"name":116,"class":6},"University of Milan",{"name":118,"class":119},"A.O.R.N. Santobono-Pausilipon","UNKNOWN",{"name":121,"class":6},"University of Modena and Reggio Emilia",{"name":123,"class":6},"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico","100545463","the-pro-future-project-100545463",false,"NCT06382233","The PRO-FUTURE Project","PRecocious biOmarkers oF Unilateral ureTero-pelvic jUnction obstRuction in childrEn","PRO-FUTURE","Inclusion Criteria:\n\n* unilateral UPJO\n* 0-5years of age\n\nExclusion Criteria:\n\n* bilateral UPJO\n* previous surgical intervention on the urinary tract\n* bladder or lower urinary tract symptoms or malformations\n* nephro- or urolithiasis, vesicoureteral reflux\n* urinary tract infections.","ALL","1 Day","5 Years",{"count":136,"type":137},85,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn about specific biomarkers of unilateral ureteropelvic junction obstruction (UPJO) in children undergoing surgical intervention for unilateral UPJO compared with controls. The main question it aims to answer are:\n\n* Are Urinary single-cell and extracellular vesicles (EVs) screening useful to stage the intrarenal injury and repair processes in UPJO babies?\n* Do babies with unilateral UPJO have a whole blood gene expression profiling (WBGEP) allowing an accurate unilateral UPJO diagnosis?",[141,142],"Ureteropelvic Junction Obstruction","Chronic Kidney Diseases",[144,145,146,147,148],"Ureteropelvic junction obstruction","Biomarkers","Single-Cell","Extracellular vesicles","Congenital anomalies of the kidney and urinary tract","2024-04-26",{"date":151,"type":152},"2024-04-30","ACTUAL",{"date":154,"type":152},"2024-01-30",{"date":156,"type":137},"2028-01-30",{"name":5,"class":6},5]