[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100525889":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":45,"responsibleParty":65,"collaborators":26,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":26,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":89,"overallStatus":47,"whyStopped":26,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"University of Illinois at Chicago","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"REACT-NMES: Intervention condition","EXPERIMENTAL","The REACT-NMES group will undergo 6 weeks of reactive balance training with NMES involving 12 one-hour sessions (twice a week). Each session will begin with NMES parameter setup where the current amplitude will be customized to individual \"maximal tolerable\" levels for a strong yet comfortable experience. NMES settings will include moderate to high intensity (30-50mA) and low frequency (20-45Hz) to target motor nerve thresholds. The REACT-NMES group will wear a footswitch on their paretic shoe for triggering the slips during walking and for NMES synchronization. NMES will be delivered to the paretic limb quadriceps muscles for 500 milliseconds after slip onset.",[13],"Behavioral: Reactive balance training with Neuromuscular Electrical Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"REACT: Control condition","ACTIVE_COMPARATOR","The REACT group will undergo 6 weeks involving 12 one-hour sessions (twice a week) of reactive balance training with ShamNMES. To prevent psychological bias and unblinding, sub-sensory stimulation will be used. ShamNMES will employ low intensity (0-10mA) and high frequency (50-100Hz), staying 20% below the sensory nerve threshold without inducing muscle contraction. The REACT group will wear a footswitch on their paretic shoe for triggering the slips during walking and for ShamNMES synchronization. ShamNMES (control) will be delivered after compensatory step touchdown to avoid interference with balance recovery.",[19],"Behavioral: Reactive balance training without Neuromuscular Electrical Stimulation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Reactive balance training with Neuromuscular Electrical Stimulation","REACT-NMES group: The ActiveStep treadmill will be used to deliver slips during all sessions. Each subject will experience three levels of perturbations over 12 sessions (24 slips\u002Fsession) in progressive ascending way. On the first week, subjects will start with the lowest displacement level (6 cm) and move up to the next level (12 cm) by week 2 if they have \\\u003C 5 falls out of 8 slips at the previous level. By week 3, subjects are expected to move to level 3 (24 cm) and train at that for weeks 3 to 6. If subjects don't move up a level, training will continue at the lower level. NMES will be delivered to the vastus lateralis synchronously with the perturbation, which will always occur 50 ms after slip-onset and last for 450 ms including the period between liftoff to touchdown of the first compensatory step.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Reactive balance training without Neuromuscular Electrical Stimulation","REACT group: The REACT group will undergo the same reactive balance training (in terms of type, dosage: intensity, frequency) as the REACT-NMES group. The only difference will be that the REACT group will receive ShamNMES for same time after the compensatory step touchdown. The ActiveStep treadmill will be used to deliver slips during all sessions. Each subject will experience three levels of perturbations over 12 sessions (24 slips\u002Fsession) in progressive ascending way. On the first week, subjects will start with the lowest displacement level (6 cm) and move up to the next level (12 cm) by week 2 if they have \\\u003C 5 falls out of 8 slips at the previous level. By week 3, subjects are expected to move to level 3 (24 cm) and train at that for weeks 3 to 6. If subjects don't move up a level, training will continue at the lower level.",[15],[32],{"name":33,"affiliation":5,"role":34},"Tanvi Bhatt","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Rudri Purohit, MS","CONTACT","312-413-9772","rpuroh2@uic.edu",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Swaranka Deshmukh, MS","312-355-3988","sdeshm9@uic.edu",[46],{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Chicago","Illinois","60612","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-87.65005,41.85003,{"lat":57,"lon":56},[60,64],{"name":61,"role":38,"phone":62,"phoneExt":26,"email":63},"Tanvi Bhatt, PhD","312-355-4443","tbhatt6@uic.edu",{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},{"type":34,"investigatorFullName":33,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Full Professor","100525889","the-reactplusnmes-trial-a-double-blinded-rct-100525889",false,"NCT06127602","The REACTplusNMES Trial: A Double-blinded RCT","NeuroMuscular Electrical Stimulation to Facilitate Perturbation-based REACtive Balance Training for Fall Risk Reduction Post-stroke: The REACTplusNMES Trial","REACT+NMES","Inclusion Criteria:\n\n* Age group: 18-90 years.\n* Presence of hemiparesis.\n* Onset of stroke (\\> 6 months).\n* Ability to walk at least for 2 minutes on the treadmill with or without ankle foot orthosis.\n* Can understand and communicate in English.\n* Cognitively and behaviorally capable of complying with the regimen (Mini-Mental State Examination \\> 25\u002F30).\n* No history or recent use (i.e., past 6 weeks) of any Neuromuscular electrical stimulation device to leg muscles during walking (e.g., Bioness, Walkaide).\n\nExclusion Criteria:\n\n* Subjects will not proceed with the test if any of the following occurs at baseline measurement: 1) HR \\> 85% of age-predicted maximal heart rate (HRmax) (HRmax = 220 - age), 2) systolic blood pressure (SBP) \\> 165 mmHg and\u002For diastolic blood pressure (DBP) \\> 110 mmHg during rest, or 3) oxygen saturation (measured by pulse oximeter) \\\u003C 95% during rest.\n* Body weight of more than 250 lbs.\n* Spasticity (Ashworth scale \\> 2).\n* Loss of protective sensations on the paretic leg (indicated by inability to perceive the 5.07\u002F10 g on Semmes-Weinstein Monofilament) or inability to feel the NMES.\n* Severe osteoporosis (indicated by T score \\\u003C -2)\n* Cognitive impairment (indicated by Mini-Mental State Exam score\\\u003C25)\n* Global Aphasia (indicated by \\\u003C71% on the Mississippi Aphasia Screening Test).\n* Subjects with Chedoke McMaster Leg Assessment Scale score (\\> 4).","ALL","18 Years","90 Years",{"count":79,"type":80},46,"ESTIMATED","INTERVENTIONAL",[83],"NA","The aim of this study is to compare the effectiveness of 6-weeks of reactive balance training (REACT) with and without neuromuscular electrical stimulation (NMES) to paretic lower limb muscles on biomechanical, clinical, neuromuscular and neuroplastic outcomes of reactive balance control. This project is a Phase-I study and incorporates a double-blinded, randomized controlled trial design.\n\nMethods: Forty-six individuals with chronic stroke will be recruited and screened for determining their eligibility for the study. Once enrolled, they will be randomized into either of the two groups: intervention group (23 participants) and control group (23 participants). Both groups will undergo series of pre-training assessments which includes a postural disturbance in the form of a slip- or trip-like perturbations and walking tests in laboratory environment. After the pre-training assessment, individuals will undergo 6-weeks of training (2 hour per session, 2 sessions per week). The intervention group will receive NMES with the REACT training and the control group will receive ShamNMES. NMES will be applied to the different muscle groups of the paretic lower limb using an advanced software which is able to synchronize muscle activation with the time of perturbation onset and according to the phases of gait. After training, both groups will again be tested on all the assessments performed pre training.\n\nThis study will help us understand the immediate therapeutic and mechanistic effects of REACT+NMES and inform stroke rehabilitation research and clinical practice. Our study will provide foundational evidence for future use of NMES to implement clinically applicable neuromodulation adjuvants to reactive balance training, which could be leveraged for designing more effective future interventions for fall-risk reduction.",[86,87,88],"Stroke, Ischemic","Stroke Hemorrhagic","Stroke, Cerebrovascular",[90,91,92,93,94,95,96,97,98],"Reactive balance","Falls","Perturbation training","NMES","FES","Stroke","Fall prevention","Neuroplastic","Neuromuscular","2025-07-31",{"date":101,"type":102},"2025-08-06","ACTUAL",{"date":104,"type":102},"2024-03-01",{"date":106,"type":80},"2026-05-31",{"name":5,"class":6},1]