[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100543362":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":20,"locations":26,"responsibleParty":45,"collaborators":47,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":54,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"University of Leicester","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Lacunar Stroke Syndrome Patients",null,"Patients who have been diagnosed with lacunar stroke syndrome. This is a non-intervention study so no intervention will be given. However, the investigators will observe the changes in cerebral haemodynamics of this group before and after they have been given medications to help control hypertension and\u002For diabetes which are common risk factors of lacunar stroke syndrome.",[13],"Device: Transcranial Doppler Ultrasonography (TCD) during sit-stand manoeuvres",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DEVICE","Transcranial Doppler Ultrasonography (TCD) during sit-stand manoeuvres","TCD will be used to measure the cerebral blood flow in the middle and posterior cerebral arteries. This will be done at rest and during two sit-stand manoeuvres, whereby the participant will be asked to stand (from a seated position) and stay standing for 1 minute. The participant will then be given time to recover before repeating the manoeuvre. This will occur at the first visit and the follow-up visit 4 weeks after.",[9],[21],{"name":22,"role":23,"phone":24,"phoneExt":10,"email":25},"Jatinder S Minhas, SFHEA","CONTACT","+44 116 252 3299","jm591@leicester.ac.uk",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"University Hospitals of Leicester NHS Trust","RECRUITING","Leicester","Leicestershire","LE1 5WW","United Kingdom","UK",{"type":36,"coordinates":37},"Point",[38,39],-1.13169,52.6386,{"lat":39,"lon":38},[42],{"name":43,"role":23,"phone":10,"phoneExt":10,"email":44},"Amit Mistri","amit.mistri@uhl-tr.nhs.uk",{"type":46,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[48,50],{"name":49,"class":6},"British Heart Foundation",{"name":51,"class":6},"University Hospitals, Leicester","100543362","the-relationship-between-controlling-risk-factors-and-cerebral-haemodynamics-in-lacunar-stroke-100543362",false,"NCT06354881","The Relationship Between Controlling Risk Factors and Cerebral Haemodynamics in Lacunar Stroke","Understanding the Relationship Between Controlling Risk Factors and Cerebral Haemodynamic Changes in Lacunar Stroke, and Its Interaction With Ageing","LACUNAR_CA","Inclusion Criteria:\n\n* Adults aged between 18-120 years.\n* Diagnosis of lacunar stroke syndrome.\n* New diagnosis or known diagnosis of hypertension and\u002For diabetes.\n\nExclusion Criteria:\n\n* Those who lack capacity can have a personal consultee consent to the study if they can still perform study requirements such as the sit-stand manoeuvre. Those who either cannot perform the manoeuvre or do not have a personal consultee to allow them to consent, are not able to take part.\n* Those with poorly controlled medical comorbidities affecting cerebral haemodynamics. (eg., heart failure).","ALL","18 Years",{"count":63,"type":64},75,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to look at differences in brain blood flow before and after management of risk factors such as high blood pressure and diabetes in patients with lacunar stroke. Participants will be asked to undergo a simple brain blood flow assessment at their initial appointment, whereby they will be asked to sit and stand twice. The patients will then be asked for a follow-up assessment 4 weeks after, identical to the first. This will allow us to look at any changes in brain blood flow from before management of risk factors and 4 weeks after management of risk factors.",[68],"Lacunar Stroke",[70,71,72,73],"Lacunar","Stroke","Cerebral Autoregulation","Cerebral Blood Flow","2025-03-21",{"date":76,"type":77},"2025-03-24","ACTUAL",{"date":79,"type":77},"2024-05-02",{"date":81,"type":64},"2026-03",{"name":5,"class":6},1]