[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595263":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":10,"centralContacts":22,"locations":28,"responsibleParty":45,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":10,"enrollmentInfo":58,"targetDuration":61,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":10,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Zhongda Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Frail group",null,"We chose the Fried Phenotypic Assessment Scale to evaluate the frailty status of the patients. The Fried Frailty Assessment Scale holds that frailty is a syndrome composed of five phenotypes: shrinking, weakness, exhaustion, low physical activity, and slowness. Meeting three or more of these phenotypes indicates a frailty status.",[13],"Other: Frailty status",{"label":15,"type":10,"description":16,"interventionNames":10},"Non-frail group","We used the Fried assessment scale to evaluate the frailty status of patients. Patients who met two or fewer indicators were evaluated as having a non-frailty status.",[18],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"Frailty status","This was an observational study with no intervention measures. The exposure factor was the frailty status of the patients.",[9],[23],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Yue Lan Zhu","CONTACT","+8618795969178","zhulanyue1993@126.com",[29],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Zhongda Hospital Southeast University","RECRUITING","Nanjing","Jiangsu","210000","China","CN",{"type":38,"coordinates":39},"Point",[40,41],118.77778,32.06167,{"lat":41,"lon":40},[44],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Lanyue Zhu","Attending Doctor","100595263","the-relationship-between-preoperative-frailty-and-postoperative-aki-and-the-mediating-effect-of-intraoperative-bp-100595263",false,"NCT07030179","The Relationship Between Preoperative Frailty and Postoperative AKI and the Mediating Effect of Intraoperative BP","The Relationship Between Preoperative Frailty and Postoperative Acute Kidney Injury in Patients Undergoing Non-cardiac Surgery and the Mediating Effect of Intraoperative Blood Pressure: A Prospective Cohort Study","Inclusion Criteria:\n\n* 18 years old or above\n* Undergo non-cardiac surgery\n\nExclusion Criteria:\n\n* At least one measurement of serum creatinine (SCr) was not conducted before and after the operation\n* End-stage renal disease (ESRD) that has received dialysis within the past year\n* Baseline SCr ≥ 4.5 mg\u002Fdl (because the clinical criteria for AKI based on elevated SCr may not be applicable to these patients)\n* Acute kidney injury occurred within 7 days before the operation\n* No frailty assessment was conducted\n* The surgical procedure is renal surgery\n* The operation time is less than 2 hours","ALL","18 Years",{"count":59,"type":60},1000,"ESTIMATED","1 Year","OBSERVATIONAL","The primary objectives of study is to compare the difference in the incidence of postoperative AKI between frail and non-frail patients. The secondary objectives of study was to compare the differences in intraoperative blood pressure fluctuations, the incidence and duration of intraoperative hypotension, postoperative extubation time, postoperative complications, length of hospital stay and hospitalization expenses between frail and non-frail patients, and use mediating effect analysis to examine the magnitude of the effect of intraoperative blood pressure on postoperative acute kidney injury caused by frailty.",[65,66],"Postoperative Acute Kidney Injury","Frailty","2026-03-27",{"date":69,"type":70},"2026-04-02","ACTUAL",{"date":72,"type":70},"2025-07-01",{"date":74,"type":60},"2026-12-31",{"name":47,"class":6},1]