[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620525":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":28,"locations":33,"responsibleParty":46,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":10,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Kanuni Sultan Suleyman Training and Research Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Fibromyalgia Group",null,"Female patients aged 18-50 years diagnosed with fibromyalgia according to the 2016 American College of Rheumatology criteria.",[13],"Other: No Intervention (Observational Study)",{"label":15,"type":10,"description":16,"interventionNames":17},"Healthy Control Group","Age- and sex-matched healthy female volunteers without fibromyalgia or chronic widespread pain.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"No Intervention (Observational Study)","This is an observational study with no therapeutic or diagnostic intervention. Participants will undergo a single-time-point clinical assessment and venous blood sampling for biomarker measurement only.",[9,15],[24],{"name":25,"affiliation":26,"role":27},"Zeynep Karakuzu Güngör, M.D","Kanuni Sultan Süleyman Training and Research Hospital","PRINCIPAL_INVESTIGATOR",[29],{"name":25,"role":30,"phone":31,"phoneExt":10,"email":32},"CONTACT","905077750375","zeynepkarakuzu@hotmail.com.tr",[34],{"facility":26,"status":35,"city":36,"state":10,"zip":10,"country":37,"countryCode":10,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Istanbul","Turkey (Türkiye)",{"type":39,"coordinates":40},"Point",[41,42],28.94966,41.01384,{"lat":42,"lon":41},[45],{"name":25,"role":30,"phone":31,"phoneExt":10,"email":32},{"type":27,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Zeynep Karakuzu Güngör","Physical Medicine and Rehabilitation Specialist","100620525","the-relationship-between-serum-s100b-and-brain-derived-neurotrophic-factor-100620525",false,"NCT07358754","The Relationship Between Serum S100B and Brain-Derived Neurotrophic Factor","The Relationship Between Serum S100B and Brain-Derived Neurotrophic Factor (BDNF) Levels and Central Sensitization and Sleep Quality in Patients With Fibromyalgia","S100B-BDNF","Inclusion Criteria:\n\n* Female participants aged between 18 and 50 years\n\nDiagnosis of fibromyalgia according to 2016 American College of Rheumatology (ACR) criteria\n\nSymptoms present for at least 3 months\n\nAbility to understand and complete study questionnaires\n\nProvision of written informed consent\n\nFor healthy controls:\n\nNo diagnosis of fibromyalgia or chronic widespread pain\n\nNo known systemic disease\n\nExclusion Criteria:\n\n\\-",true,"FEMALE","18 Years","50 Years",{"count":62,"type":63},60,"ESTIMATED","OBSERVATIONAL","Fibromyalgia is a chronic pain syndrome characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive symptoms. Central sensitization is considered a key mechanism in the pathophysiology of fibromyalgia; however, the underlying biological markers have not been fully clarified.\n\nBrain-derived neurotrophic factor (BDNF) and S100B protein have been suggested to play roles in neuroinflammation and central pain processing. This observational, cross-sectional study aims to evaluate serum S100B and BDNF levels in patients with fibromyalgia and to investigate their relationship with central sensitization and sleep quality. Serum biomarker levels and clinical assessment scales will be compared between patients with fibromyalgia and healthy controls.",[67],"Fibromyalgia","2026-04-10",{"date":70,"type":71},"2026-04-15","ACTUAL",{"date":73,"type":71},"2026-02-01",{"date":75,"type":63},"2026-04-30",{"name":5,"class":6},1]