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Aged over 18\n2. Previous H\\&N SCC treated with radiotherapy with or without chemotherapy\n3. Local or regionally recurrent, residual, or new primary SCC of the oropharynx, oral cavity, larynx, and hypopharynx\n4. Ability to give informed consent for biological sample collection (molecular analysis study only)\n\nExclusion Criteria:\n\n1. Nasopharyngeal and cutaneous SCC of the H\\&N\n2. Thyroid, salivary gland, and non-squamous cell H\\&N cancers\n3. Presence of distant metastasis (M1) or surgically inoperable T4b tumours","ALL","18 Years",{"count":157,"type":158},400,"ESTIMATED","OBSERVATIONAL","The RESCUE study is a combined retrospective and prospective multicentre cohort study investigating the survival and functional outcomes in patients undergoing salvage surgery for recurrent, residual, and new primary head and neck squamous cell carcinoma (SCC).\n\nAdditionally, the RESCUE study will contain an exploratory molecular analysis of consenting patients to assess the relationship between cancer genomics, previous radiotherapy, and recurrence in head and neck cancer.",[162],"Head and Neck Cancer","2026-02-09",{"date":165,"type":166},"2026-02-12","ACTUAL",{"date":168,"type":166},"2023-09-08",{"date":170,"type":158},"2029-04-30",{"name":5,"class":6},9]