[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100583763":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":43,"responsibleParty":61,"collaborators":25,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":25,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":25,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":90,"whyStopped":25,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Tulane University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"CDN of Renal arteries Arm","PLACEBO_COMPARATOR","Catheter-based endovascular denervation (CDN) of renal arteries only, without splanchnic nerve denervation",[13],"Device: Renal Denervation Only",{"label":15,"type":16,"description":17,"interventionNames":18},"CND of Renal Arteries and Splanchnic Nerves Arm","EXPERIMENTAL","Catheter-based endovascular denervation (CDN) of renal arteries and splanchnic nerves (celiac + SMA) using radiofrequency ablation",[19,13],"Device: Splanchnic Nerve Denervation",[21,26],{"type":22,"name":23,"description":17,"armGroupLabels":24,"otherNames":25},"DEVICE","Splanchnic Nerve Denervation",[15],null,{"type":22,"name":27,"description":11,"armGroupLabels":28,"otherNames":25},"Renal Denervation Only",[9,15],[30],{"name":31,"affiliation":5,"role":32},"Jose Wiley, MD, MPH, FACC, FACP, FSCAI","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Chris Wang, MS","CONTACT","504-988-3065","hwang37@tulane.edu",{"name":40,"role":36,"phone":41,"phoneExt":25,"email":42},"Suzanne Bowers, RN, BSN","504-988-2030","sbowers@tulane.edu",[44],{"facility":45,"status":25,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"East Jefferson General Hospital","New Orleans","Louisiana","70006","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-90.07507,29.95465,{"lat":55,"lon":54},[58,59,60],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},{"name":40,"role":36,"phone":41,"phoneExt":25,"email":42},{"name":31,"role":32,"phone":25,"phoneExt":25,"email":25},{"type":62,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100583763","the-resplash-study-100583763",false,"NCT06880562","The RESPLASH Study","Renal and Splanchnic Sympathetic Denervation as an Alternative Therapy for Resistant Hypertension and Type 2 Diabetes (RESPLASH Study)","Inclusion Criteria:\n\n* Patients aged 18-75.\n* History of Type 2 Diabetes Mellitus at least 5 years prior to enrollment.\n* HbA1c level ≥6.5%\n* Use of at least 1 oral antidiabetic agent and no changes in the last 30 days.\n* History of essential hypertension with systolic Blood pressure of 160 mmHg or more (≥150 mmHg in patient with Type 2 Diabetes Mellitus), despite compliance with three of more antihypertensive drugs.\n* Stable drug regimen of at least 3 antihypertensive medications with no changes for 2 weeks before enrollment.\n\nExclusion Criteria:\n\n* Estimated glomerular filtration rate of less than 30 mL\u002Fmin per 1.73m2.\n* Type 1 diabetes mellitus.\n* History of aortic pathologies such as aneurysm or dissection confirmed by immediate preprocedural angiography that would preclude the Endovascular Denervation (EDN) procedure.\n* Orthostatic hypotension.\n* Acute or severe systemic infection.\n* History of myocardial infarction, unstable angina, or cerebrovascular accident in the previous 3 months.\n* History of previous renal artery CDN.\n* Pregnancy or planned pregnancy during the study period.\n* Unable to provide informed consent.","ALL","18 Years","75 Years",{"count":74,"type":75},20,"ESTIMATED","INTERVENTIONAL",[78],"NA","To assess the safety and effectiveness of renal artery denervation with subsequent splanchnic nerves denervation via catheter-based radiofrequency ablation in improving blood pressure and glycemic control in patients with resistant hypertension and type 2 diabetes.",[81],"Resistant Hypertension",[83,84,85,86,87,88,89],"Renal Sympathetic Denervation","Splanchnic Sympathetic Denervation","Hypertension","Diabetes mellitus","Catheter-based radiofrequency ablation","Lowering blood pressure","Control of glycemic levels","NOT_YET_RECRUITING","2026-02-27",{"date":93,"type":94},"2026-03-03","ACTUAL",{"date":96,"type":75},"2026-06",{"date":98,"type":75},"2027-06",{"name":5,"class":6},1]