[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100141239":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":18,"responsibleParty":48,"collaborators":7,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":7,"eligibilityCriteria":55,"healthyVolunteers":52,"sex":56,"minAge":7,"maxAge":7,"enrollmentInfo":57,"targetDuration":7,"studyType":60,"phases":7,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":21,"whyStopped":7,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"The Rogosin Institute","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Lisa C. Hudgins, M.D.","Weill Medical College of Cornell University","PRINCIPAL_INVESTIGATOR",[14],{"name":10,"role":15,"phone":16,"phoneExt":7,"email":17},"CONTACT","(212) 746-3561","lih2013@med.cornell.edu",[19],{"facility":20,"status":21,"city":22,"state":22,"zip":23,"country":24,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"Weill Cornell Medical College","RECRUITING","New York","10021","United States","US",{"type":27,"coordinates":28},"Point",[29,30],-74.00597,40.71427,{"lat":30,"lon":29},[33,35,37,40,42,44,46],{"name":10,"role":15,"phone":34,"phoneExt":7,"email":17},"212-746-3561",{"name":36,"role":12,"phone":7,"phoneExt":7,"email":7},"Lisa Hudgins, M.D.",{"name":38,"role":39,"phone":7,"phoneExt":7,"email":7},"Daniel Levine, Ph.D.","SUB_INVESTIGATOR",{"name":41,"role":39,"phone":7,"phoneExt":7,"email":7},"Geoffrey Bergman, M.D.",{"name":43,"role":39,"phone":7,"phoneExt":7,"email":7},"Sheila Carroll, M.D.",{"name":45,"role":39,"phone":7,"phoneExt":7,"email":7},"Ajay Mirani, M.D.",{"name":47,"role":39,"phone":7,"phoneExt":7,"email":7},"Akiko Maehera, M.D.",{"type":49,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100141239","the-rogosin-institute-homozygous-familial-hypercholesterolemia-repository-100141239",false,"NCT01109368","The Rogosin Institute Homozygous Familial Hypercholesterolemia Repository","Inclusion criteria:\n\n1\\. Patients of any age and sex who meet clinical or genetic criteria for hoFH as follows:\n\n* Documented, untreated fasting LDL cholesterol level of \\> 500 mg\u002FdL and triglycerides \\\u003C 200 mg\u002FdL on a cholesterol-lowering diet for at least 8 weeks with secondary causes excluded, AND:\n\n  * DNA confirmation of a double mutation of the LDL receptor or apoB gene OR\n  * LDL \\> 160 mg\u002FdL in both biological parents not associated with a disorder know to elevate LDL OR\n  * Coronary artery disease in one or both parents or grandparents \\\u003C 55 years for males, \\\u003C 65 for females OR\n  * Tendinous\u002Fcutaneous xanthomas \\\u003C age 10 or coronary artery disease \\\u003C age 20\n\nExclusion criteria:\n\n1\\. Inability of patient, or, if less than 18, a parent, to sign informed consent.","ALL",{"count":58,"type":59},60,"ESTIMATED","OBSERVATIONAL","This repository will establish for the first time a system to carefully assess and monitor over time the general health and the amount of cholesterol in the arteries of U.S. children and adults with homozygous familial hypercholesterolemia (hoFH). Patients with this very rare disorder have very high blood levels of cholesterol from birth due to the inheritance of an abnormal gene from each parent. As a result, if untreated, heart attacks and sudden death occur in childhood. Treatments such as LDL-apheresis and liver transplant will lower the cholesterol level, but the best treatment and the best way to monitor the effect of the treatment on the arteries are unknown. The collection of clinical data and blood for analysis of known and yet-to-be discovered markers and predictors of arterial disease will yield new information about the natural history of the disorder and response to treatment. The repository will greatly aid the development of specific protocols that seek to learn more about this disease and new therapies.",[63],"Homozygous Familial Hypercholesterolemia",[65],"Autosomal Dominant Familial Hypercholesterolemia","2026-03-31",{"date":68,"type":69},"2026-04-06","ACTUAL",{"date":71,"type":69},"2010-06",{"date":73,"type":59},"2030-05",{"name":5,"class":6},1]