[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615365":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":20,"centralContacts":30,"locations":39,"responsibleParty":52,"collaborators":19,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":19,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":19,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":76,"overallStatus":83,"whyStopped":19,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Assiut University","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"High resolution anorectal manometry using multiuse water perfused catheter","Solar™ GI High Resolution Anorectal Manometry with multiuse water perfused catheter",[12],"Device: High resolution anorectal manometry using a multiuse water perfused catheter",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"DEVICE","High resolution anorectal manometry using a multiuse water perfused catheter","According to the international anorectal physiology working group recommendations(8):\n\nStabilization: A 3-minute period after catheter insertion to allow anal tone to return to baseline.\n\n* Rest: Measures basal anal tone over 60 seconds.\n* Squeeze: Records anal pressure during voluntary contraction. Three 5-second squeezes are performed.\n* Long Squeeze: Evaluates anal pressure and fatigue during a single sustained 30-second contraction.\n* Cough: Assesses reflex anal pressure changes during two single coughs.\n* Push: Measures pressure changes during simulated defecation. Three 15-second pushes are performed.\n* RAIR (Rectoanal Inhibitory Reflex): Tests reflex anal relaxation after rapid rectal balloon distension, starting with at least 30 mL.\n\nRectal Sensory Test: Measures rectal sensitivity by recording balloon volumes at three thresholds: first constant sensation, desire to defecate, and maximum tolerated volumes.\n\n· Balloon Expulsion: time required to expel the balloon.",[9],null,[21,25,28],{"name":22,"affiliation":23,"role":24},"Naglaa H. Ibrahim, Professor","Assiut University- Faculty of medicine","STUDY_DIRECTOR",{"name":26,"affiliation":23,"role":27},"Naglaa S. Mohamed, A. professor","STUDY_CHAIR",{"name":29,"affiliation":23,"role":27},"Rehab I. Hassan, Lecturer",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":19,"email":35},"Yasser M. Abd Elaal, Master","CONTACT","+201021356722","Yasser.mohamed412@gmail.com",{"name":37,"role":33,"phone":38,"phoneExt":19,"email":19},"Nagla H. Ibrahim, Professor","+20111187223",[40],{"facility":41,"status":19,"city":42,"state":19,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":19},"Assiut University-faculty of medicine","Asyut","71511","Egypt","EG",{"type":47,"coordinates":48},"Point",[49,50],31.18368,27.18096,{"lat":50,"lon":49},{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"PRINCIPAL_INVESTIGATOR","Yasser Mohamed Abd Elaal Ahmed","Doctor","100615365","the-role-of-anorectal-manometry-in-pediatric-chronic-refractory-constipation-100615365",false,"NCT07291661","The Role of Anorectal Manometry in Pediatric Chronic Refractory Constipation","The Role of Anorectal Manometry in Diagnosing and Guiding Management of Pediatric Chronic Refractory Constipation","Inclusion Criteria:\n\n1. Children and adolescents aged from 4 to 18 years.\n2. Participants who have chronic refractory constipation either functional or organic with or without fecal incontinence.\n3. Cooperative patients.\n\nExclusion Criteria:\n\n1. Children aged less than 4 years old.\n2. Uncooperative patients.\n3. Children with anal fissures or any painful conditions that interfere with the procedure.","ALL","4 Years","18 Years",{"count":67,"type":68},54,"ESTIMATED","INTERVENTIONAL",[71],"NA","This research protocol outlines a two-year descriptive cross-sectional study to investigate the role of high-resolution anorectal manometry (HRAM) in children aged 4-18 years with chronic refractory constipation.The study plans to enroll 54 patients at Ain Shams University Specialized Hospital . The study aims to identify different patterns of anorectal dysfunction (like dyssynergic defecation or rectal hyposensitivity) using standardized international protocols. A key goal is to determine if these manometry findings can directly guide specific management strategies, such as biofeedback therapy for dyssynergia or botulinum toxin injections for anal hypertension. improving outcomes for children who do not respond to standard constipation therapies.",[74,75],"Refractory Constipation","Fecal Incontinence in Children",[77,78,79,80,81,82],"Anorectal manometry","Functional constipation","Pediatric chronic refractory constipation","Fecal incontinence","Biofeedback therapy","Botox injection","NOT_YET_RECRUITING","2025-12-05",{"date":86,"type":87},"2025-12-18","ACTUAL",{"date":89,"type":68},"2026-01-01",{"date":91,"type":68},"2027-12-31",{"name":5,"class":6},1]