[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100562665":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":27,"locations":37,"responsibleParty":77,"collaborators":79,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":10,"eligibilityCriteria":90,"healthyVolunteers":87,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":10,"studyType":97,"phases":10,"briefSummary":98,"conditions":99,"keywords":106,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"University of Florida","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Major Trauma Injury",null,"Severe blunt trauma patients diagnosed with shock with a long bone or pelvic fracture requiring open reduction internal fixation or intramedullary fixation.",[13],"Other: Data and tissue collection",{"label":15,"type":10,"description":16,"interventionNames":17},"Elective Hip Replacement","Patients undergoing elective hip replacement surgery",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Data and tissue collection","Collection of bone marrow, blood, feces, medical record data, and patient response surveys.",[15,9],[24],{"name":25,"affiliation":5,"role":26},"Alicia Mohr, MD","PRINCIPAL_INVESTIGATOR",[28,33],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Ruth Davis, BSN","CONTACT","352-273-8759","ruth.davis@surgery.ufl.edu",{"name":34,"role":30,"phone":35,"phoneExt":10,"email":36},"Jennifer Lanz, MSN","352-273-5497","jennifer.lanz@surgery.ufl.edu",[38,60,69],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"UF Academic Research Building","RECRUITING","Gainesville","Florida","32610","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-82.32483,29.65163,{"lat":50,"lon":49},[53,57],{"name":54,"role":30,"phone":55,"phoneExt":10,"email":56},"Kolenkode B Kannan, PhD","352-273-8455","Kolenkode.Kannan@surgery.ufl.edu",{"name":25,"role":30,"phone":58,"phoneExt":10,"email":59},"352-273-5670","alicia.mohr@surgery.ufl.edu",{"facility":61,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":62,"geoPoint":64,"contacts":65},"UF Health at Shands Hospital",{"type":47,"coordinates":63},[49,50],{"lat":50,"lon":49},[66,67,68],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},{"name":34,"role":30,"phone":35,"phoneExt":10,"email":10},{"name":25,"role":26,"phone":10,"phoneExt":10,"email":10},{"facility":70,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":71,"geoPoint":73,"contacts":74},"UF Laboratory of Inflammation Biology and Surgical Science and Shands Hospital at UF",{"type":47,"coordinates":72},[49,50],{"lat":50,"lon":49},[75],{"name":76,"role":26,"phone":10,"phoneExt":10,"email":10},"Alicia L Mohr, MD",{"type":78,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[80,83],{"name":81,"class":82},"National Institutes of Health (NIH)","NIH",{"name":84,"class":82},"National Institute of General Medical Sciences (NIGMS)","100562665","the-role-of-brain-bone-marrow-gut-interaction-following-major-trauma-100562665",false,"NCT06606119","The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma","Severe Trauma Cohort\n\nInclusion Criteria:\n\n1. All adults (age ≥18).\n2. Blunt trauma with an injury severity score \\> 15 and a long bone or pelvic fracture requiring open reduction internal fixation or intramedullary fixation\n3. Blunt trauma patients with shock, defined by either a systolic BP (SBP) \\\u003C90 mm Hg or base deficit (BD) ≥5 meq or lactate ≥ 2 mmol\u002FL or active red blood cell or whole blood transfusion within 6h or arrival\n\nExclusion Criteria:\n\n1. Patients not expected to survive greater than 48 hours\n2. Prisoners\n3. Pregnancy\n4. Previous bone marrow transplantation\n5. Patients receiving chronic corticosteroids or immunosuppression therapies\n6. Patients with End Stage Renal Disease\n7. Patients with any pre-existing hematological disease\n8. Surgery for repair of injury is greater than seven days after admission to the hospital for trauma\n9. Burn injury greater than 20% TBSA\n\nElective Hip Cohort\n\nInclusion Criteria\n\n1. All adults (age ≥55).\n2. Patient undergoing elective hip repair for non-infectious reasons.\n3. Ability to obtain Informed Consent prior to operation.\n\nExclusion Criteria\n\n1. Patients not expected to survive greater than 48 hours\n2. Prisoners\n3. Pregnancy\n4. Previous bone marrow transplantation\n5. Patients receiving chronic corticosteroids or immunosuppression therapies\n6. Patients with End Stage Renal Disease\n7. Patients with any pre-existing hematological disease","ALL","18 Years","100 Years",{"count":95,"type":96},275,"ESTIMATED","OBSERVATIONAL","Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery. This project will define the interactions between the stress, chronic inflammation, bone marrow dysfunction, and an altered microbiome which will provide a strong foundation for future clinical interventions to help improve outcomes following severe trauma.",[100,101,102,103,104,105],"Trauma Injury","Trauma","Critical Illness","Microbiome","Chronic Anemia","Acute Blood Loss Anemia",[107,108,109,110,111,112],"Hematopoietic Stem Progenitor Cells","Bone Marrow Failure","Anemia","Gut Microbiome","Inflammation","Dysregulated Stress Response","2026-02-04",{"date":115,"type":116},"2026-02-06","ACTUAL",{"date":118,"type":116},"2025-01-24",{"date":120,"type":96},"2028-10-01",{"name":5,"class":6},3]