[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629088":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":36,"centralContacts":45,"locations":51,"responsibleParty":76,"collaborators":79,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":36,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":36,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":103,"overallStatus":107,"whyStopped":36,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":117},{"fullName":5,"class":6},"Indiana University","OTHER",[8,16,19,22,25,28],{"label":9,"type":10,"description":11,"interventionNames":12},"Ambient noise, then music distraction, then increased ventilation auditory feedback","ACTIVE_COMPARATOR","Participants will complete 3 full length breathing tasks, one under each auditory condition. The order of condition exposure will be assigned via randomization.",[13,14,15],"Other: Ambient Noise","Other: Increased Auditory Feedback","Other: Noise Distraction",{"label":17,"type":10,"description":11,"interventionNames":18},"Ambient noise, then increased ventilation auditory feedback, then music distraction",[13,14,15],{"label":20,"type":10,"description":11,"interventionNames":21},"Music distraction, then ambient noise, then increased ventilation auditory feedback",[13,14,15],{"label":23,"type":10,"description":11,"interventionNames":24},"Increased ventilation auditory feedback, then ambient noise, then music distraction",[13,14,15],{"label":26,"type":10,"description":11,"interventionNames":27},"Increased ventilation auditory feedback, then music distraction, then ambient noise",[13,14,15],{"label":29,"type":10,"description":11,"interventionNames":30},"Music distraction, then increased ventilation auditory feedback, then ambient noise",[13,14,15],[32,37,41],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"Ambient Noise","Participants will complete the breathing task with ambient (or normal) auditory feedback (\\~10 decibels).",[17,9,23,26,20,29],null,{"type":6,"name":38,"description":39,"armGroupLabels":40,"otherNames":36},"Increased Auditory Feedback","Participants will complete the breathing task with increased auditory feedback of ventilation (\\~70 decibels). Specifically, a small microphone will be placed in the device that participants breathe through to increase the sound of the participants breath.",[17,9,23,26,20,29],{"type":6,"name":42,"description":43,"armGroupLabels":44,"otherNames":36},"Noise Distraction","Participants will complete the breathing task without auditory feedback of ventilation. Specifically, participants will wear noise cancelling headphones and will listen to a self-selected music playlist at a constant volume (\\~80 decibels).",[17,9,23,26,20,29],[46],{"name":47,"role":48,"phone":49,"phoneExt":36,"email":50},"Timothy D Mickleborough, PhD","CONTACT","812-855-0753","tmickleb@iu.edu",[52],{"facility":53,"status":36,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Multidisciplinary Engineering and Sciences Hall (MESH)","Bloomington","Indiana","47405","United States","US",{"type":60,"coordinates":61},"Point",[62,63],-86.52639,39.16533,{"lat":63,"lon":62},[66,70,74],{"name":67,"role":48,"phone":68,"phoneExt":36,"email":69},"Scott M Clarke","812-856-3244","scotclar@iu.edu",{"name":71,"role":48,"phone":72,"phoneExt":36,"email":73},"Zachary J Schalder, PhD","812-855-6953","zschlade@iu.edu",{"name":47,"role":75,"phone":36,"phoneExt":36,"email":36},"PRINCIPAL_INVESTIGATOR",{"type":75,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":36,"oldOrganization":36},"Tim Mickleborough","Professor",[80],{"name":81,"class":82},"United States Department of Defense","FED","100629088","the-role-of-breathing-perception-in-respiratory-control-100629088",false,"NCT07470099","The Role of Breathing Perception in Respiratory Control","Optimizing Mind-Body Interactions in Respiratory Control During Operationally Relevant Environmental Stressors","Inclusion Criteria:\n\n* Between the ages of 18-40 years old.\n* English speaking and reading.\n* Self-reported weekly activity of at least 120 minutes\u002Fweek of high intensity exercise for the previous 2 years.\n* Normal pulmonary function assessed by a resting forced expiratory volume in 1 second over forced vital capacity (FEV1\u002FFVC) \\> 75% of predicted.\n* Normal cognitive function assessed using the Montreal cognitive function test \\[18\\].\n* Body mass index (BMI) ≤ 35 kg\u002Fm2.\n* Females with a regular menstrual cycle that ranges from 21-35 days (eumenorrhea)\n\nExclusion Criteria:\n\n* History of smoking or recreational smoking, cardiovascular disease, renal disease, pulmonary disease (including asthma or exercise-induced asthma), neurological disease, and metabolic disease.\n* Are pregnant or could possibly be pregnant by self-report.\n* Are color blind.\n* Known allergy or hypersensitivity latex.\n* Take selective serotonin reuptake inhibitors, stimulant medication, antibiotics, and chronically consume pain medication (Aleve, Tylenol, etc.).\n* Resting blood pressure of \\> 130mmHg systolic or 90 mmHg diastolic and\u002For resting pulse rate of \\> 100 bpm.\n* Females with irregular menstrual cycles (oligomenorrhea) that ranges from 36-90 days, and females with the absence of a menstrual cycle (amenorrhea).\n* Taking birth control for the sole purpose of period cessation (eg., Mirena IUD)",true,"ALL","18 Years","40 Years",{"count":95,"type":96},15,"ESTIMATED","INTERVENTIONAL",[99],"NA","Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing apparatuses. Elevated WOB then increases the perception of breathing difficulty (dyspnea) and has been associated with impaired cognitive performance, including slower reaction time and reduced accuracy during attention-demanding tasks. These effects are particularly concerning in operational settings that require rapid decision-making and precise motor responses.\n\nDespite growing recognition of this issue, critical gaps remain regarding strategies to mitigate the perceptual and cognitive consequences of elevated inspiratory resistance, especially under realistic operational stressors. The objective of this experiment is to determine whether modifying the sensory perception of breathing alters breathing perception and cognitive performance during inspiratory resistance. Auditory feedback of ventilation will be manipulated (normal, reduced, or amplified) to assess whether altering breathing-related sensory input affects breathing perception and cognitive performance without changing mechanical load.",[102],"Work of Breathing",[104,105,106],"Dyspnea Perception","Cognitive Performance","Auditory Distraction","NOT_YET_RECRUITING","2026-03-10",{"date":110,"type":111},"2026-03-13","ACTUAL",{"date":113,"type":96},"2027-06-01",{"date":115,"type":96},"2028-09-30",{"name":5,"class":6},1]