[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100322771":3},{"organization":4,"armGroups":7,"interventions":34,"overallOfficials":39,"centralContacts":43,"locations":52,"responsibleParty":70,"collaborators":73,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":24,"eligibilityCriteria":83,"healthyVolunteers":79,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":24,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":99,"overallStatus":55,"whyStopped":24,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Washington University School of Medicine","OTHER",[8,14,17,20,25,27,29,32],{"label":9,"type":10,"description":11,"interventionNames":12},"Pneumonia: Blue Light","EXPERIMENTAL","a 12 hours:12 hours light:dark photoperiod cycle of bright (1700 lux) blue (peak 442 nm) enriched light for a total of 3 days after the initial diagnosis and informed consent. The photoperiod is 12 hours: 0800 to 2000. At the transition from light to dark (2000), the blue-enriched light is turned off, and additional blue wavelength light removed with an amber filter.",[13],"Other: Blue Light",{"label":15,"type":10,"description":11,"interventionNames":16},"Intraabdominal infection: Blue Light",[13],{"label":18,"type":10,"description":11,"interventionNames":19},"Necrotizing Soft Tissue Infection: Blue Light",[13],{"label":21,"type":22,"description":23,"interventionNames":24},"Pneumonia: Ambient Light","NO_INTERVENTION","a 12 hours:12 hours light:dark photoperiod cycle of the standard white fluorescent ambient light of the hospital for a total of 3 days after the initial diagnosis and informed consent. The photoperiod is 12 hours: 0800 to 2000. At the transition from light to dark (2000), the ambient white lights are turned off.",null,{"label":26,"type":22,"description":23,"interventionNames":24},"Intraabdominal infection: Ambient Light",{"label":28,"type":22,"description":23,"interventionNames":24},"Necrotizing Soft Tissue Infection: Ambient Light",{"label":30,"type":10,"description":11,"interventionNames":31},"Infected Joint: Blue Light",[13],{"label":33,"type":22,"description":23,"interventionNames":24},"Infected Joint: Ambient Light",[35],{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":24},"Blue Light","Subjects that are to be exposed to blue light will be provided by the research personnel with a Day-Light Classic 10,000 lumen SAD light, a device that has been used in many of the previously listed published studies (Epilepsy Behav. 2012 Jul;24(3):359-64. doi: 10.1016\u002Fj.yebeh.2012.04.123. Epub 2012 May 30.) The light is small (4 X 16 X 21 inches) and weights less than a pound. It is UV filtered and glare free. There is a single \"On\u002FOff\" switch. It will be attached to a rolling stand.\n\nThis light is fitted with a blue spectrum filter (peak 442 nm) such that it produces 1700 Lux of blue spectrum lighting when positioned at a distance of 12 inches from the subject. Those subjects assigned to blue light will be asked to shine this small portable blue enriched light on themselves from 0800 to 2000 for 3 days.",[30,15,18,9],[40],{"name":41,"affiliation":5,"role":42},"Matthew R Rosengart, MD MPH","PRINCIPAL_INVESTIGATOR",[44,48],{"name":41,"role":45,"phone":46,"phoneExt":24,"email":47},"CONTACT","314-362-5298","matthew.r@wustl.edu",{"name":49,"role":45,"phone":50,"phoneExt":24,"email":51},"Xianghong Zhang, PhD","412-215-6134","xianghong@wustl.edu",[53],{"facility":54,"status":55,"city":56,"state":57,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"Barnes Jewish Hospital","RECRUITING","St Louis","Missouri","63108","United States","US",{"type":62,"coordinates":63},"Point",[64,65],-90.19789,38.62727,{"lat":65,"lon":64},[68,69],{"name":41,"role":45,"phone":46,"phoneExt":24,"email":47},{"name":49,"role":45,"phone":50,"phoneExt":24,"email":51},{"type":42,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Matthew R. Rosengart","Professor",[74],{"name":75,"class":76},"National Institute of General Medical Sciences (NIGMS)","NIH","100322771","the-role-of-circadian-clock-proteins-in-innate-and-adaptive-immunity-100322771",false,"NCT03482245","The Role of Circadian Clock Proteins in Innate and Adaptive Immunity","Light Therapy in Patients Undergoing an Operation for a Septic Joint, Necrotizing Soft Tissue Infection, Intraabdominal Sepsis, or Medical Treatment of Pneumonia","Inclusion Criteria:\n\n* greater than or equal to 18 years of age and less than or equal to 65 years of age\n* one of the following diagnoses requiring inpatient hospital care\n\n  1. an operation for intraabdominal infection\n  2. an operation for necrotizing soft tissue infection\n  3. an operation for an infected joint\n  4. medical treatment of pneumonia.\n\nExclusion Criteria:\n\n* traumatic brain injury\n* blindness\n* immunocompromised or immunosuppressed state\n* infection requiring treatment in preceding 30 days\n* blindness\n* SARS-CoV-2","ALL","18 Years","65 Years",{"count":88,"type":89},144,"ESTIMATED","INTERVENTIONAL",[92],"NA","Our data suggest that modulating the characteristics of light carries the potential to modify the host response to injury and critical illness and thus, improve outcome. The ability to modify the host response to the stress of major operations and sepsis carries immense potential to improve patient care.\n\nThe primary purpose of this study is to determine if exposure to bright blue (442nm) enriched light, by comparison to ambient white fluorescent light, reduces the inflammatory response or organ dysfunction in patients undergoing 1) medical treatment for pneumonia, 2) a 2-stage arthroplasty for surgical management of a septic joint, 3) surgery for a necrotizing soft tissue infection (NSTI), and 4) surgery for an intraabdominal infection (e.g., diverticulitis).\n\nWe will expose participants to one of two (2) lighting conditions: 1) high illuminance (\\~1700 lux,), blue (442nm) spectrum enriched light and 2) ambient white fluorescent light that provides the standard environmental lighting (\\~300-400 lux, no predominant spectrum) of the hospital.\n\nBoth cohorts will be exposed to a 12 hours:12 hours light:dark cycle photoperiod. Those subjects assigned to blue light will be asked to shine this small portable blue enriched light on themselves from 0800 to 2000 for 3 days. At the transition from light to dark, the blue-enriched light is turned off, and additional blue wavelength light removed with an amber filter. Thus, the total period of intervention is 72 hours.\n\nThe outcome of interest is change in the inflammatory response after surgery for appendicitis or diverticulitis as measured by the following parameters: white blood cell count, heart rate, the development of abdominal abscess, serum cytokine concentrations.\n\nThe outcome of interest is change in the inflammatory response during pneumonia as measured by the following parameters: white blood cell count, heart rate, and serum cytokine concentrations.",[95,96,97,98],"Pneumonia","Necrotizing Soft Tissue Infection","Intraabdominal Infections","Infection Joint",[100,101,102,103,104,105],"pneumonia","soft tissue infection","intraabdominal infections","circadian rhythms","blue light","sepsis","2026-02-08",{"date":108,"type":109},"2026-02-11","ACTUAL",{"date":111,"type":109},"2024-10-29",{"date":113,"type":89},"2026-12-31",{"name":5,"class":6},1]