[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100457882":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":22,"centralContacts":27,"locations":33,"responsibleParty":50,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":54,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":10,"studyType":64,"phases":10,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Retrospective cohort",null,"Patients with acute ischemic stroke admitted to the Stroke Unit of one participating center in 2018-2022. The data collected within clinical routine will be analyzed including stroke characteristics at baseline and at discharge (10-14 days after admission), neuroimaging data, sleep characteristics (routine polygraphy study), heart rate variability, routine blood tests.",[13],"Other: No intervention is planned",{"label":15,"type":10,"description":16,"interventionNames":17},"Prospective cohort","Approximately 200-250 patients with acute ischemic stroke admitted to the Stroke Unit of one participating center in 2022-2024 will undergo the assessment of medical records, stroke characteristics, the assessment of sleep characteristics and blood sampling for the evaluation of genetic biomarkers of circadian rhythms at baseline (within 2-3 days of admission) and at 10-14 days (at discharge).",[13],[19],{"type":6,"name":20,"description":20,"armGroupLabels":21,"otherNames":10},"No intervention is planned",[15,9],[23],{"name":24,"affiliation":25,"role":26},"Lyudmila Korostovtseva, MD, PhD","Almazov National Medical Research Centre","PRINCIPAL_INVESTIGATOR",[28],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Lyudmila Korostovtseva, MD, PHD","CONTACT","+79217873548","lyudmila_korosto@mail.ru",[34],{"facility":25,"status":35,"city":36,"state":10,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Saint Petersburg","197341","Russia","RU",{"type":41,"coordinates":42},"Point",[43,44],30.31413,59.93863,{"lat":44,"lon":43},[47],{"name":48,"role":30,"phone":49,"phoneExt":10,"email":32},"Lyudmila Korostovtseva","89217873548",{"type":26,"investigatorFullName":48,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Senior Researcher, Department for Hypertension","100457882","the-role-of-circadian-factors-in-regulation-of-neuroplasticity-in-ischemic-stroke-observational-100457882",false,"NCT05242393","The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Observational)","Inclusion Criteria:\n\n* acute (symptom onset to admission \\\u003C1 days) ischemic stroke\n* ischemic stroke affecting the branches of anterior cerebral artery, middle cerebral artery and posterior cerebral artery\n* age 18-80 years\n* moderate or severe stroke (National Institutes of Health Stroke Scale, NIHSS\\>=5)\n* intravascular stroke treatment with thrombolysis or thrombectomy leading to satisfactory reperfusion (if applicable)\n* informed consent\n\nExclusion Criteria:\n\n* secondary parenchymal hemorrhage (\\>hemorrhage index -2)\n* clinically unstable or life-threatening conditions\n* known progressive neurological diseases\n* known psychiatric diseases\n* concomitant benzodiazepine medication\n* drug or alcohol abuse\n* pregnancy\n* disability to participate in the study\n* congestive heart failure with reduced ejection fraction (\\\u003C=45%) or New York Heart Association (NYHA) classification III-IV functional class","ALL","18 Years","80 Years",{"count":62,"type":63},250,"ESTIMATED","OBSERVATIONAL","The study is aimed at the investigation of the association of biomarkers of circadian rhythms with sleep characteristics and stroke outcome in acute stroke patients. It is designed as an observational cohort study with the retrospective and prospective longitudinal arms.",[67,68],"Stroke, Ischemic","Sleep Disorder",[70,71,72,73,74,75,76,77],"neuroplasticity","cognitive dysfunction","disability","circadian rhythm","functional deficit","stroke outcome","sleep-disordered breathing","heart rate variability","2025-08-05",{"date":80,"type":81},"2025-08-08","ACTUAL",{"date":83,"type":81},"2018-05-01",{"date":85,"type":63},"2026-12-31",{"name":5,"class":6},1]