[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629087":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":36,"centralContacts":45,"locations":51,"responsibleParty":76,"collaborators":79,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":36,"eligibilityCriteria":89,"healthyVolunteers":90,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":36,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":103,"overallStatus":108,"whyStopped":36,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Indiana University","OTHER",[8,16,19,22,25,28],{"label":9,"type":10,"description":11,"interventionNames":12},"Thermoneutral temperature, then Cold temperature, then Hot temperature","ACTIVE_COMPARATOR","Participants will complete 3 experimental visits at which they will complete a breathing task under an assigned temperature condition. The order of condition exposure will be assigned via randomization.",[13,14,15],"Other: Thermoneutral temperature environment","Other: Cold temperature environment","Other: Hot temperature environment",{"label":17,"type":10,"description":11,"interventionNames":18},"Thermoneutral temperature, then Hold temperature, then Cot temperature",[13,14,15],{"label":20,"type":10,"description":11,"interventionNames":21},"Cold temperature, then Thermoneutral temperature, then Hot temperature",[13,14,15],{"label":23,"type":10,"description":11,"interventionNames":24},"Cold temperature, then Hot temperature, then Thermoneutral temperature",[13,14,15],{"label":26,"type":10,"description":11,"interventionNames":27},"Hot temperature, then Thermoneutral temperature, then Cold temperature",[13,14,15],{"label":29,"type":10,"description":11,"interventionNames":30},"Hot temperature, then Cold temperature, then Thermoneutral temperature",[13,14,15],[32,37,41],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"Thermoneutral temperature environment","During thermoneutral conditions 34°C water will be perfused through special suit while participants resting the chamber set to 24°C and 40% room humidity.",[23,20,29,26,9,17],null,{"type":6,"name":38,"description":39,"armGroupLabels":40,"otherNames":36},"Cold temperature environment","During the cold condition, 4°C water will be perfused through the special suit while participants rest in the chamber set to 4°C and 10% room humidity.",[23,20,29,26,9,17],{"type":6,"name":42,"description":43,"armGroupLabels":44,"otherNames":36},"Hot temperature environment","During the hot condition, 50°C water will be perfused through the special suit while participants rest in the chamber set to 40°C and 40% room humidity.",[23,20,29,26,9,17],[46],{"name":47,"role":48,"phone":49,"phoneExt":36,"email":50},"Timothy D Mickleborough, PhD","CONTACT","812-855-0753","tmickleb@iu.edu",[52],{"facility":53,"status":36,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Multidisciplinary Engineering and Sciences Hall (MESH)","Bloomington","Indiana","47405","United States","US",{"type":60,"coordinates":61},"Point",[62,63],-86.52639,39.16533,{"lat":63,"lon":62},[66,70,74],{"name":67,"role":48,"phone":68,"phoneExt":36,"email":69},"Scott M Clarke","812-856-3244","scotclar@iu.edu",{"name":71,"role":48,"phone":72,"phoneExt":36,"email":73},"Zachary J Schalder, PhD","812-855-6953","zschlade@iu.edu",{"name":47,"role":75,"phone":36,"phoneExt":36,"email":36},"PRINCIPAL_INVESTIGATOR",{"type":75,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":36,"oldOrganization":36},"Tim Mickleborough","Professor",[80],{"name":81,"class":82},"United States Department of Defense","FED","100629087","the-role-of-environmental-temperatures-in-respiratory-control-100629087",false,"NCT07470086","The Role of Environmental Temperatures in Respiratory Control","Optimizing Mind-Body Interactions in Respiratory Control During Operationally Relevant Environmental Stressors","Inclusion Criteria:\n\n* Between the ages of 18-40 years old.\n* English speaking and reading.\n* Self-reported weekly activity of at least 120 minutes\u002Fweek of high intensity exercise for the previous 2 years.\n* Normal pulmonary function assessed by a resting forced expiratory volume in 1 second over forced vital capacity (FEV1\u002FFVC) \\> 75% of predicted.\n* Normal cognitive function assessed using the Montreal cognitive function test \\[18\\].\n* Body mass index (BMI) ≤ 35 kg\u002Fm2.\n* Females with a regular menstrual cycle that ranges from 21-35 days (eumenorrhea)\n\nExclusion Criteria:\n\n* History of smoking or recreational smoking, cardiovascular disease, renal disease, pulmonary disease (including asthma or exercise-induced asthma), neurological disease, and metabolic disease.\n* Are pregnant or could possibly be pregnant by self-report.\n* Are color blind.\n* Known allergy or hypersensitivity latex.\n* Take selective serotonin reuptake inhibitors, stimulant medication, antibiotics, and chronically consume pain medication (Aleve, Tylenol, etc.).\n* Resting blood pressure of \\> 130mmHg systolic or 90 mmHg diastolic and\u002For resting pulse rate of \\> 100 bpm.\n* Females with irregular menstrual cycles (oligomenorrhea) that ranges from 36-90 days, and females with the absence of a menstrual cycle (amenorrhea).\n* Taking birth control for the sole purpose of period cessation (eg., Mirena IUD)",true,"ALL","18 Years","40 Years",{"count":95,"type":96},15,"ESTIMATED","INTERVENTIONAL",[99],"NA","Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing apparatuses. Elevated WOB increases the perception of breathing difficulty (dyspnea) and has been associated with impaired cognitive performance, including slower reaction time and reduced accuracy during attention-demanding tasks. These effects are particularly concerning in operational settings that require rapid decision-making and precise motor responses.\n\nDespite growing recognition of this issue, critical gaps remain regarding strategies to mitigate the perceptual and cognitive consequences of elevated inspiratory resistance, especially under realistic operational stressors. The objective of this study is to determine whether exposing individuals to thermal stress alters breathing perception and cognitive performance during inspiratory resistance. Participants will perform inspiratory resistance breathing under thermoneutral, heat, and cold conditions to determine whether thermal stress amplifies WOB, breathing perception, and cognitive impairment.",[102],"Work of Breathing",[104,105,106,107],"Inspiratory Resistance","Dyspnea Perception","Cognitive Performance","Thermal Stress","NOT_YET_RECRUITING","2026-03-10",{"date":111,"type":112},"2026-03-13","ACTUAL",{"date":114,"type":96},"2028-10-01",{"date":116,"type":96},"2029-12-31",{"name":5,"class":6},1]