[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640449":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":43,"centralContacts":47,"locations":54,"responsibleParty":71,"collaborators":35,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":35,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":57,"whyStopped":35,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"Wilfrid Laurier University","OTHER",[8,14,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo Comparator","PLACEBO_COMPARATOR","Participants will be randomized and placed into one of four groups. The placebo group will receive 400 milligrams (mg) per day of glucose polymer for 13 days total. The supplementation will be consumed orally at the same time every day for 13 days total. Participants will not complete more than one arm of the study.",[13],"Drug: Placebo Comparator",{"label":15,"type":16,"description":17,"interventionNames":18},"Estradiol Only","EXPERIMENTAL","Participants will receive 1 mg per day for 2 days and 2 mg per day of estradiol for 11 days + 300 mg polycose. The supplementation will be consumed orally at the same time every day for 13 days total. Participants will not complete more than one arm of the study.",[19],"Drug: Estradiol Only",{"label":21,"type":16,"description":22,"interventionNames":23},"Progesterone Only","Participants will receive 100 mg per day of Prometrium (oral progesterone) for 13 days. The supplementation will be consumed orally at the same time every day for 13 days total. Participants will not complete more than one arm of the study.",[24],"Drug: Progesterone Only",{"label":26,"type":16,"description":27,"interventionNames":28},"Estradiol and Progesterone Combo","Participants will receive 1 mg per day for 2 days and 2 mg per day estradiolfor 11 days + 300 mg polycose as well as 100 mg per day of Prometrium (oral progesterone). The supplementation will be consumed orally at the same time every day for 13 days total. Participants will not complete more than one arm of the study.",[29],"Drug: Estradiol and Progesterone Combination",[31,36,38,40],{"type":32,"name":9,"description":33,"armGroupLabels":34,"otherNames":35},"DRUG","See description of intervention arm.",[9],null,{"type":32,"name":15,"description":33,"armGroupLabels":37,"otherNames":35},[15],{"type":32,"name":21,"description":33,"armGroupLabels":39,"otherNames":35},[21],{"type":32,"name":41,"description":33,"armGroupLabels":42,"otherNames":35},"Estradiol and Progesterone Combination",[26],[44],{"name":45,"affiliation":5,"role":46},"Tom J Hazell, PhD","PRINCIPAL_INVESTIGATOR",[48],{"name":49,"role":50,"phone":51,"phoneExt":52,"email":53},"Jessica Tucker, MKin, PhD Candidate","CONTACT","519-884-1970","4919","tuck5010@mylaurier.ca",[55],{"facility":56,"status":57,"city":58,"state":59,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"Energy Metabolism Research Laboratory","RECRUITING","Waterloo","Ontario","N2L 3C5","Canada","CA",{"type":64,"coordinates":65},"Point",[66,67],-80.51639,43.4668,{"lat":67,"lon":66},[70],{"name":49,"role":50,"phone":51,"phoneExt":52,"email":53},{"type":46,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"Tom Hazell","Principal Investigator","100640449","the-role-of-estradiol-and-progesterone-on-appetite-regulation-and-energy-balance-100640449",false,"NCT07620587","The Role of Estradiol and Progesterone on Appetite Regulation and Energy Balance","E2 & P4 in EB","Inclusion Criteria:\n\n* ages 18-30 years\n* deemed healthy using Canadian Society for Exercise Physiology Get Active Questionnaire (CSEP-GAQ)\n* non-smoking\n\nExclusion Criteria:\n\n* failure to meet inclusion criteria\n* contraindications to exercise as indicated by the (CSEP-GAQ)\n\n  * hypersensitivity or allergy to estradiol, progesterone, cellulose, or capsule components\n  * having been diagnosed with any metabolic disease (ie. diabetes, metabolic syndrome) or current diagnosis of overweight\u002Fobesity (BMI \\> 30.0)\n  * personal of family history of stroke or thrombotic (blood clot) disease, blood clot disorder, venous or arterial thromboembolic disease, or any possible blood clotting disease\n  * currently taking anticoagulants, antidiabetic medications, cyclosporine, antihypertensives, and CYP3A4 inducers or inhibitors (e.g., rifampin, ketoconazole, St. John's Wort)\n  * known liver dysfunction or liver disease\n  * history of ophthalmic vascular disease\n  * hormone-dependent malignancies or previous diagnosis of cancer\n  * recent major surgery (within \\~6 months)\n  * prolonged use of a cast or presence of immobility deeming inability to exercise, diagnosis of inflammatory disorders (ie. rheumatoid arthritis, celiac disease, inflammatory bowel disease)\n  * history of sensitivity to or extreme nausea\u002Fvomiting or any gastrointestinal disorder\n  * diagnosis of mental health or mood disorder\n  * presence of abnormal eating behaviours as assessed by the Food Cravings State Questionnaire and the Three Factor Eating Questionnaire\n  * diagnosed or presence of porphyria or classical migraines",true,"MALE","18 Years","30 Years",{"count":86,"type":87},60,"ESTIMATED","INTERVENTIONAL",[90],"NA","The goal of this study is to determine if estradiol and progesterone are involved in appetite regulation and energy balance. The study aims to complete a 13 day randomized controlled trial (RCT) where oral supplementation of estradiol only, progesterone only, a combination of each, or a placebo in young males will be provided. During the supplementation period, participants will complete two in-lab sessions where they will complete an acute bout of high-intensity interval training or a period of seated rest (completed on separate days by each participant) and have blood samples and perceptions of appetite measured taken over the course of the in-lab sessions. At the end of each session participants will consume an ad-libitum meal and participants will also track free-living energy intake and wear a thigh-worn accelerometer to measure energy expenditure for three days (day before, day of, and day after) each in-lab session.",[93,94],"Energy Balance","Physiology - Regulation of Appetite and Food Intake",[96,97,98,99,100,101],"ovarian hormones","energy intake","appetite regulation","appetite-regulating hormones","energy balance","regulation of food intake","2026-05-26",{"date":104,"type":105},"2026-06-02","ACTUAL",{"date":107,"type":87},"2026-06-01",{"date":109,"type":87},"2028-08-31",{"name":5,"class":6},1]