[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100310982":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":25,"responsibleParty":39,"collaborators":25,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":25,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":25,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":25,"overallStatus":61,"whyStopped":25,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":25},{"fullName":5,"class":6},"University of Nevada, Reno","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Inhibitory control training","EXPERIMENTAL","In the inhibitory control training condition, participants will be trained with tasks that involve both response withholding and rule switching. For example, participants will sort polygons based on features (e.g., shape or color) and will be asked to either provide or withhold sorting responses when presented with different cues. Rule-switching is introduced when participants must inhibit the \"rule\" used in the previous trial set and change the focus of their attention to a new sorting and\u002For inhibitory rule. Task difficulty will progressively increase over the course of training based on participants' abilities.",[13],"Behavioral: Inhibitory control training",{"label":15,"type":16,"description":17,"interventionNames":18},"knowledge-based training","SHAM_COMPARATOR","The knowledge-based training condition serves as the control, in which participants will be presented with questions from different categories such as vocabulary, science, or geography and asked to select the correct answer from 4 alternatives within a certain time limit. Task difficulty will progressively increase over the course of training based on participants' abilities.",[19],"Behavioral: Knowledge-based training",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Cognitive training is inhibitory task-related.",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Knowledge-based training","Training is not inhibitory task-related.",[15],[31],{"name":32,"affiliation":5,"role":33},"Fang Jiang, Ph.D","PRINCIPAL_INVESTIGATOR",[35],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","775-682-8606","fangj@unr.edu",{"type":33,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Fang Jiang","Associate professor","100310982","the-role-of-gaba-mediated-inhibition-in-multisensory-temporal-processing--postural-control-in-older-adults-100310982",false,"NCT03328455","The Role of GABA-mediated Inhibition in Multisensory Temporal Processing & Postural Control in Older Adults","Inclusion Criteria:\n\n* Age between 65 and 80 (elderly group) and between 20 and 35 (young group)\n\nExclusion Criteria:\n\n* History of epilepsy, stroke, Parkinson's disease, Alzheimer's disease, attention deficit-hyperactivity disorder\n* History of head injury with loss of consciousness, brain surgery, or psychiatric disorders\n* Early dementia or cognitive impairment\n* Serious vision problems (including best-corrected binocular visual acuity worse than 20\u002F25)\n* Uncorrected hearing problems (pure tone threshold \\> 40 dB for 1000-2000 Hz)",true,"ALL","20 Years","80 Years",{"count":53,"type":54},50,"ESTIMATED","INTERVENTIONAL",[57],"NA","In recent years evidence has accumulated on the association between age-related decline in multisensory temporal processing and postural control. This proposed project aims at examining GABA-mediated inhibition as the potential mechanism behind this link. Our overarching hypothesis is that changes in the excitatory-inhibitory balance with a reduction of GABAergic inhibition is a common mechanism underlying age-related multisensory and postural deficits potentially mediated by age-related reduction in network segregation. To test this hypothesis, we will assess the relationship between age-related multisensory\u002Fpostural deficits and age-related reduction in GABA concentration in related brain areas and probe the role of GABA-mediated inhibition using cognitive training that specifically targets inhibitory functions. Our multimodal approach is innovative, and findings from this study has the potential to lead to the development of safe and effective rehabilitation protocols for older adults with impaired multisensory temporal integration and postural control.",[60],"Healthy Aging","NOT_YET_RECRUITING","2026-04-27",{"date":64,"type":65},"2026-05-01","ACTUAL",{"date":67,"type":54},"2027-12-01",{"date":69,"type":54},"2031-11-30",{"name":5,"class":6}]