[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612479":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":21,"responsibleParty":37,"collaborators":41,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":10,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":10,"maxAge":10,"enrollmentInfo":52,"targetDuration":10,"studyType":55,"phases":10,"briefSummary":56,"conditions":57,"keywords":66,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Riga Stradins University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Non-smoking periodontitis patients",null,"Non-smoking Stage III-IV Grade B-C periodontitis patients with at least one infra-osseous approximal bone defect (with ≥3 mm infrabony component) at premolar-molar region (n=23).",{"label":13,"type":10,"description":14,"interventionNames":10},"Smoking periodontitis patients","Smoking Stage III-IV Grade B-C periodontitis patients with at least one infra-osseous approximal bone defect (with ≥3 mm infrabony component) at premolar-molar region (n=23).",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Dārta E Emuliņa, DDS","CONTACT","+37122007988","dartaemulina@gmail.com",[22],{"facility":23,"status":24,"city":25,"state":10,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"Riga Stradins University Institute of Stomatology","RECRUITING","Riga","LV-1013","Latvia","LV",{"type":30,"coordinates":31},"Point",[32,33],24.10589,56.946,{"lat":33,"lon":32},[36],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dārta Elizabete Emuliņa","PhD student",[42],{"name":43,"class":6},"University of Turku","100612479","the-role-of-granulation-tissue-in-periodontal-regeneration-100612479",false,"NCT07254117","The Role of Granulation Tissue in Periodontal Regeneration","The Role of Biochemical and Microbiological Properties of Granulation Tissue in Periodontal Regeneration","Inclusion Criteria:\n\n1. Both genders.\n2. Systemically healthy.\n3. Both smokers (smoking at least 10 cigarettes a day or electronic cigarettes daily or quit less than 5 years ago) and non-smokers (never smoked, smoke no more than once a month or quit at least 5 years ago).\n4. Patients aged 18 years and over.\n5. Patients with a history of severe periodontitis (stage III or IV, grade B-C) and, after completion of the non-surgical stage of periodontal treatment with at least one residual vertical bone defects (with ≥3 mm infrabony component) in premolar-molar region.\n6. Patients with a plaque index and bleeding on probing of 20% or lower before surgery.\n\nExclusion Criteria:\n\n1. Systemic diseases that may affect study results (uncontrolled type 2 diabetes mellitus (HBA1c level of \\>7%); recent (less than 6 months ago) myocardial infarction or stroke; blood coagulation disorders; recent use of antibiotics (less than 6 months).\n2. Use of medications that may affect study results (anti-osteoporotic drugs, statins, corticosteroids, calcium channel blockers, cyclosporine A, antiepileptic drugs, antipsychotic medication or antidepressants, chemotherapy and\u002For radiotherapy (active or history)).\n3. Current pregnancy and\u002For breastfeeding.\n4. Patients who have received any form of systemic antibiotics in the last six months prior to the start of the study.\n5. Patients who require antibiotic premedication prior to periodontal treatment.\n6. Prosthetic factors in teeth associated with suitable bone defects that prevent clinical measurements.\n7. Lack of patient motivation to undertake adequate dental care at home or to complete periodontal treatment.\n8. Strong vomiting reflex preventing adequate periodontal treatment.","ALL",{"count":53,"type":54},46,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to distinguish the infectious, healing, and regeneration-related characteristics of two types of gingival granulation tissues, namely infra-osseous and supra-osseous granulation tissues, in people with severe periodontitis (gum disease). Researchers aim to denote if these tissues may play role in healing after periodontal treatment. Researchers will also compare smokers and non-smokers to see if smoking disrupts the healing potential or infectious properties of granulation tissue. Participants will provide gingival fluid (before) and granulation tissue samples (at the time of) periodontal surgery. The main questions this study aims to answer are: 1. Do infra- and supra-osseous granulation tissues have different healing potential and infectious properties? 2. How do these tissues differ in people who smoke compared to people who do not smoke?",[58,59,60,61,62,63,64,65],"Periodontal Bone Loss","Periodontitis","Periodontal Disease","Periodontal Diseases","Periodontal Regeneration","Periodontal Granulation Tissue","Vertical Periodontal Bone Defects","Periodontal Healing",[67,59,68,69,70,71,72],"Periodontal granulation tissue","Vertical periodontal bone defects","Vertical defects","Granulation tissue","Periodontal regeneration","Periodontal healing","2025-11-19",{"date":75,"type":76},"2025-11-28","ACTUAL",{"date":78,"type":76},"2025-05-29",{"date":80,"type":54},"2026-09",{"name":5,"class":6},1]