[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100517471":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":38,"centralContacts":43,"locations":53,"responsibleParty":74,"collaborators":47,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":47,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":84,"minAge":85,"maxAge":47,"enrollmentInfo":86,"targetDuration":47,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":99,"overallStatus":56,"whyStopped":47,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Universitaire Ziekenhuizen KU Leuven","OTHER",[8,15],{"label":9,"type":6,"description":10,"interventionNames":11},"Possible non-convulsive status epilepticus with ictal-interictal continuum EEG patterns","Patients with a possible non-convulsive status epilepticus, according to American Clinical Neurophysiology Criteria (ACNS) (2021).",[12,13,14],"Diagnostic Test: MRI scan including arterial spin labelling of the brain","Diagnostic Test: CT perfusion scan of the brain","Diagnostic Test: FDG-PET scan of the brain",{"label":16,"type":6,"description":17,"interventionNames":18},"Healthy control subjects","Healthy control subjects.",[12,13,14],[20,27,32],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIAGNOSTIC_TEST","MRI scan including arterial spin labelling of the brain","Arterial Spin Labelling sequence, T2-weighted FLAIR images and T1-weighted images and diffusion weighted imaging sequence will be recorded",[16,9],[26],"Brain perfusion",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"CT perfusion scan of the brain","Siemens Naeotom Alpha with quantum technology (photon-counting)",[16,9],[26],{"type":21,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"FDG-PET scan of the brain","An FDG-PET scan will be acquired on a GE Signa 3T PET-MR scanner. FDG-PET images will be assessed for focal hypermetabolism, including semiquantitative analysis of the maximal standard uptake value (SUVmax) relative to the SUVmax of the pons (SUVr pons)",[16,9],[37],"Brain metabolism",[39],{"name":40,"affiliation":41,"role":42},"Wim Van Paesschen, MD PhD","UZ Leuven","PRINCIPAL_INVESTIGATOR",[44,49],{"name":40,"role":45,"phone":46,"phoneExt":47,"email":48},"CONTACT","+3216344332",null,"Wim.vanpaesschen@kuleuven.be",{"name":50,"role":45,"phone":51,"phoneExt":47,"email":52},"Jeroen Gijs, MD","+3216344280","Jeroen.gijs@uzleuven.be",[54],{"facility":55,"status":56,"city":57,"state":47,"zip":58,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"University Hospitals Leuven, department of Neurology","RECRUITING","Leuven","3000","Belgium","BE",{"type":62,"coordinates":63},"Point",[64,65],4.70093,50.87959,{"lat":65,"lon":64},[68,72],{"name":69,"role":45,"phone":70,"phoneExt":47,"email":71},"Wim Van Paesschen, MD, PhD","+ 32 16 344280","wim.vanpaesschen@uzleuven.be",{"name":73,"role":45,"phone":47,"phoneExt":47,"email":47},"Van Paesschen Wim, MD, PhD",{"type":75,"investigatorFullName":47,"investigatorTitle":47,"investigatorAffiliation":47,"oldNameTitle":47,"oldOrganization":47},"SPONSOR","100517471","the-role-of-imaging-in-the-diagnosis-management-and-prognosis-of-possible-non-convulsive-status-epilepticus-100517471",false,"NCT06017973","The Role of Imaging in the Diagnosis, Management and Prognosis of Possible Non-convulsive Status Epilepticus","The Role of Cerebral Functional, Structural and Spectral Imaging in the Diagnosis, Management and Prognosis of Status Epilepticus: a Prospective Study in Patients with the Ictal-interictal Continuum","Inclusion Criteria:\n\n\\- The patient has possible non-convulsive status epilepticus with scalp or invasive EEG with ictal-interictal continuum patterns on EEG\n\nExclusion Criteria:\n\n* The patient has a contra-indication for MRI such as metal implants\n* The patient has contrast sensitivity\n* The patiensuffers from claustrophobia or cannot tolerate confinement during PET-MRI scanning procedures",true,"ALL","16 Years",{"count":87,"type":88},200,"ESTIMATED","INTERVENTIONAL",[91],"NA","The investigators propose a prospective study of 20 control subjects and 180 consecutive patients with possible non-convulsive status epilepticus (NCSE). The investigators will obtain three functional images of the brain:\n\n1. Fluorodeoxyglucose positron emission tomography (FDG-PET)\n2. Perfusion (and structural) magnetic resonance (MR) images\n3. Computed tomography (CT) perfusion.\n\nBrain hypermetabolism\u002Fhyperperfusion is a strong argument to confirm a diagnosis of non-convulsive status epilepticus.\n\nThe aim is to determine which of the three functional imaging techniques is the most sensitive and easy to obtain in the detection of hypermetabolism\u002Fhyperperfusion. The investigators will determine which EEG patterns are associated with hypermetabolism\u002Fperfusion.\n\nThe investigators will further study and describe the management with antiseizure medication and outcome of the group with possible non-convulsive status epilepticus WITH hypermetabolism\u002Fhyperperfusion versus the group with possible non-convulsive status epilpticus WITHOUT hypermetabolism\u002Fhyperperfusion.\n\nThe investigators will make recommendations for an imaging protocol in possible NCSE for widespread use. The aim is to offer guidelines to incorporate imaging in the diagnosis, management and prognosis of NCSE in patients with the ictal-interictal continuum.",[94,95,96,97,98],"Status Epilepticus","Ictal-interictal Continuum","Positron-emission Tomography","Perfusion Weighted MRI","Perfusion CT",[100,101,102,103,104,105],"possible non-convulsive status epilepticus","ictal-interictal continuum","EEG","MRI","FDG-PET","CT perfusion","2024-12-23",{"date":108,"type":109},"2024-12-27","ACTUAL",{"date":111,"type":109},"2023-10-01",{"date":113,"type":88},"2027-09-30",{"name":5,"class":6},1]