[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100427991":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":31,"locations":36,"responsibleParty":49,"collaborators":25,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":25,"enrollmentInfo":62,"targetDuration":25,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Assistance Publique - Hôpitaux de Paris","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"SPA patient","ACTIVE_COMPARATOR","Patients with SPA",[13],"Procedure: Biopsy",{"label":15,"type":16,"description":17,"interventionNames":18},"Subject without SPA","SHAM_COMPARATOR","Health subjects without SPA, planned to undergo a digestive endoscopy.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Biopsy","Biopsy during recto-coloscopy",[9,15],null,[27],{"name":28,"affiliation":29,"role":30},"Maxime BREBAN, MD, PhD","Service de Rhumatologie, Hôpital Ambroise Paré, APHP","PRINCIPAL_INVESTIGATOR",[32],{"name":28,"role":33,"phone":34,"phoneExt":25,"email":35},"CONTACT","+33 1 49 09 56 72","maxime.breban@aphp.fr",[37],{"facility":29,"status":38,"city":39,"state":25,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":25},"RECRUITING","Boulogne-Billancourt","92100","France","FR",{"type":44,"coordinates":45},"Point",[46,47],2.24128,48.83545,{"lat":47,"lon":46},{"type":50,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100427991","the-role-of-intestinal-microbiota-dysbiosis-in-the-development-of-spondyloarthritis-100427991",false,"NCT04853212","The Role of Intestinal Microbiota Dysbiosis in the Development of Spondyloarthritis","The Role of Dysbiosis of Intestinal Microbiota in the Development of Spondyloarthritis","RUMINOSPA","Inclusion Criteria:\n\nPatients with SPA:\n\n* Patients ⩾ 18 years;\n* Diagnosed as spondyloarthritis (SpA) according ASAS classification;\n* Affiliated to a social security scheme;\n* Have signed the written informed consent form.\n\nControl subjects:\n\n* Subjects ⩾ 18 years;\n* Subjects free of SPA and planned for a digestive endoscopy for another indication such as to explore the risk of colorectal cancer in family member;\n* Affiliated to a social security scheme;\n* Have signed the written informed consent form.\n\nExclusion Criteria:\n\n* Subjects unable to understand the proposed study and\u002For sign a informed consent form;\n* Pregnant women or breast feeding women;\n* Subjects under guardianship or curatorship;\n* Have taken antibiotic 1 month prior to inclusion;\n* Presenting acute or chronic severe pathology may likely to interfere with the interpret of outcome;\n* Refusal of subjects to participate to the study;\n* Foreign patients under french AME scheme.",true,"ALL","18 Years",{"count":63,"type":64},100,"ESTIMATED","INTERVENTIONAL",[67],"NA","The primary objective of this case-control study aims to explore the role of bacterium Ruminococcus gnavus (R. gnavus) with intestinal biopsy and faecal sampling in the initiation and the development of spondyloarthritis (SPA) in comparison with health control subjets (patients without chronic disease but have indication to digestive endoscopy).",[70,71],"Spondyloarthritis","Ruminococcus Gnavus",[70,73,74,75],"Ruminococcus gnavus","Microbiota","Dysbiosis","2025-03-17",{"date":78,"type":79},"2025-03-19","ACTUAL",{"date":81,"type":79},"2021-06-14",{"date":83,"type":64},"2026-05",{"name":5,"class":6},1]