[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602299":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":22,"collaborators":10,"id":26,"slug":27,"hasResults":28,"nctId":29,"briefTitle":30,"officialTitle":30,"acronym":31,"eligibilityCriteria":32,"healthyVolunteers":33,"sex":34,"minAge":35,"maxAge":36,"enrollmentInfo":37,"targetDuration":40,"studyType":41,"phases":10,"briefSummary":42,"conditions":43,"keywords":45,"overallStatus":50,"whyStopped":10,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":10},{"fullName":5,"class":6},"Aydin Adnan Menderes University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"with hypotension",null,"Patients with a 30% decrease in SBP from baseline and a decrease in MAP below 65 mmHg in the first 10 minutes after anesthesia induction will be considered to have hypotension.",[13],"Drug: Inotrope",{"label":15,"type":10,"description":11,"interventionNames":10},"none hypotension",[17],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"DRUG","Inotrope","Hypotensive attacks with MAP below 55 mmHg or prolonged duration (2 minutes or more) will be treated with ephedrine 0.1 mg\u002Fkg.",[9],{"type":23,"investigatorFullName":24,"investigatorTitle":25,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","ferdi gülaştı","asst. prof.dr","100602299","the-role-of-left-ventricular-outflow-tract-lvot-velocity-time-integral-vti-and-respiratory-variability-at-peak-rate-vpeak-in-predicting-hypotension-after-general-anesthesia-induction-100602299",false,"NCT07121699","The Role of Left Ventricular Outflow Tract (LVOT) Velocity-time Integral (VTI) and Respiratory Variability at Peak Rate (Vpeak) in Predicting Hypotension After General Anesthesia Induction","LVOT-VTI-hypot","Inclusion Criteria:\n\n* 18-75 years\n* ASA Physical Status 1-3;\n* Patients scheduled for general anesthesia\n\nExclusion Criteria:\n\n1. Patient is pregnant\n2. Post-cardiac surgery\n3. Severe pulmonary hypertension\n4. Severe valvular disease\n5. Hypertrophic or dilated cardiomyopathy\n6. Presence of acute myocardial infarction\n7. Patients with severe visual or hearing impairment\u002Fimpairment\n8. ASA physical status IV or V\n9. Ischemic heart disease, conduction disturbance\n10. History of long-term use of certain medications (β-blockers, angiotensin-converting enzyme inhibitors, analgesics, sedatives, or tricyclic antidepressants)",true,"ALL","18 Years","75 Years",{"count":38,"type":39},100,"ESTIMATED","1 Day","OBSERVATIONAL","Preoperatively, patients will undergo transthoracic echocardiography measurements approximately 15-30 minutes before induction. TTE will be performed on all patients by an experienced observer; the echocardiography device will be equipped with an S4-2 transducer (4-2 MHz frequency range) in the left lateral decubitus position.\n\nVTI and Vpeak values of the LVOT were measured from manually drawn contours using pulsatile wave Doppler technique in the apical five-chamber view. The Doppler beam was aligned with the aortic blood flow, and the signal was captured at an appropriate angle (\\\u003C20°).\n\nThe maximum (VTImax) and minimum (VTImin) VTI, as well as the maximum (Vpeakmax) and minimum (Vpeakmin) Vpeak values, were determined over three respiratory cycles. ΔVTI was calculated with the following formula:\n\nΔVTI = \\[2 × (VTImax - VTImin) \u002F (VTImax + VTImin)\\] × 100%.\n\nΔVpeak was calculated with the following formula:\n\nΔVpeak = \\[2 × (Vpeakmax - Vpeakmin) \u002F (Vpeakmax + Vpeakmin)\\] × 100%. These parameters were analyzed to evaluate the hemodynamic status of patients and estimate fluid responsiveness.\n\nPatients with a 30% decrease from baseline in SBP and a decrease in MAP below 60 mmHg in the first 10 minutes after anesthesia induction were considered to have hypotension. Patients were divided into two groups: \"with\" and \"without\" hypotension.",[44],"Hypotension on Induction",[46,47,48,49],"respiratory variability in peak velocity (Vpeak)","left ventricular outflow tract (LVOT) velocity-time integral (VTI)","general anesthesia","hypotension","NOT_YET_RECRUITING","2025-08-07",{"date":53,"type":54},"2025-08-13","ACTUAL",{"date":56,"type":39},"2025-08-20",{"date":58,"type":39},"2025-09-01",{"name":5,"class":6}]