[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100500271":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":34,"locations":44,"responsibleParty":64,"collaborators":67,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":24,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":24,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":47,"whyStopped":24,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Rutgers, The State University of New Jersey","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Clean Air, Then Ozone","EXPERIMENTAL","Subjects will be exposed to clean air for 3 hours at the first exposure visit and 0.2ppm ozone for 3 hours at the second exposure visit. The visits will be at least 2 weeks apart.",[13,14],"Other: Clean Air","Other: Ozone",{"label":16,"type":10,"description":17,"interventionNames":18},"Ozone, Then Clean Air","Subjects will be exposed to 0.2 ppm ozone for 3 hours at the first exposure visit and clean air for 3 hours at the second exposure visit. The visits will be at least 2 weeks apart.",[13,14],[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Clean Air","Subjects will be exposed to clean air for 3 hours.",[9,16],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Ozone","Subjects will be exposed to 0.2 ppm ozone for 3 hours.",[9,16],[30],{"name":31,"affiliation":32,"role":33},"Howard M Kipen, MD","Rutgers School of Public Health","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":24,"email":39},"Kathleen Black, PhD","CONTACT","8484456049","kgblack@eohsi.rutgers.edu",{"name":41,"role":37,"phone":42,"phoneExt":24,"email":43},"Adriana De Resende","848-445-0178","ad998@eohsi.rutgers.edu",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Rutgers - EOHSI","RECRUITING","Piscataway","New Jersey","08854","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-74.39904,40.49927,{"lat":57,"lon":56},[60,63],{"name":61,"role":37,"phone":62,"phoneExt":24,"email":39},"Kathy Black, PhD","848-445-6049",{"name":41,"role":37,"phone":42,"phoneExt":24,"email":43},{"type":33,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Howard M. Kipen, MD, MPH","Professor",[68],{"name":69,"class":70},"National Institute of Environmental Health Sciences (NIEHS)","NIH","100500271","the-role-of-macrophage-activation-in-lung-injury-following-ozone-exposure-100500271",false,"NCT05794087","The Role of Macrophage Activation in Lung Injury Following Ozone Exposure","Activated Macrophages and Ozone Toxicity II","Exclusion Criteria:\n\n* Cardiovascular disease\n* Respiratory disease\n* Recent (within 4 weeks) respiratory or COVID-19 symptoms\n* Diabetes\n* Pregnancy\n* HIV Infection\n* History of smoking within the past 5 years.\n* Orthopedic or rheumatologic conditions which would interfere with cycle use\n* Inability to produce a sputum plug at screening\n* Daily use of antioxidant supplements, excluding those in a multivitamin. These supplements include Vitamin C or E, selenium, beta-carotene, lycopene, lutein, zeaxanthin and ginkgo biloba. Supplements taken less frequently but at least once a week will be reviewed by the principal investigator for eligibility determination.",true,"ALL","18 Years","40 Years",{"count":83,"type":84},120,"ESTIMATED","INTERVENTIONAL",[87],"NA","The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. The exposure visits will be at least 2 weeks apart. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.",[90],"Air Pollution",[92],"Macrophage","2025-12-12",{"date":95,"type":96},"2025-12-17","ACTUAL",{"date":98,"type":96},"2023-02-07",{"date":100,"type":84},"2027-06-01",{"name":5,"class":6},1]