[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587513":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":64,"collaborators":66,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":25,"maxAge":77,"enrollmentInfo":78,"targetDuration":25,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"The Gut Microbiome Center (Centar za crijevni mikrobiom)","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"patient group 1","EXPERIMENTAL","Arm 1: Probiotic-Placebo Sequence Description: Participants will consume Omni Biotic Stress (multistrain probiotic formulation) once daily for 8 weeks during the first phase, followed by an 8-week washout period, and then placebo once daily for 8 weeks during the second phase.\n\nInterventions:\n\nDietary Supplement: Omni Biotic Stress; Other: Placebo",[13,14],"Dietary Supplement: Omni Biotic Stress","Other: Placebo",{"label":16,"type":10,"description":17,"interventionNames":18},"patient group 2","Arm 2: Placebo-Probiotic Sequence Description: Participants will consume placebo once daily for 8 weeks during the first phase, followed by an 8-week washout period, and then Omni Biotic Stress once daily for 8 weeks during the second phase.\n\nInterventions:\n\nOther: Placebo; Dietary Supplement: Omni Biotic Stress\n\nParticipants will record adherence and any potential side effects in an online form. Researchers will check the number of used sachets to ensure accuracy of adherence data.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Omni Biotic Stress","Multistrain probiotic formulation (Omni Biotic Stress), 1 sachet daily for 8 weeks",[9,16],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Placebo","Inert powder identical in appearance and taste to probiotic, 1 sachet daily for 8 weeks",[9,16],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Ira Renko, MS","CONTACT","955096473","ira.renko@gmail.com",[37],{"facility":38,"status":39,"city":40,"state":25,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"University Hospital Center Zagreb","RECRUITING","Zagreb","10000","Croatia","HR",{"type":45,"coordinates":46},"Point",[47,48],15.97798,45.81444,{"lat":48,"lon":47},[51,53,56,58,60,62],{"name":32,"role":33,"phone":25,"phoneExt":25,"email":52},"info@ccm.hr",{"name":54,"role":33,"phone":25,"phoneExt":25,"email":55},"Andrija Karacic, dr.med","andrija@ccm.hr",{"name":32,"role":57,"phone":25,"phoneExt":25,"email":25},"PRINCIPAL_INVESTIGATOR",{"name":54,"role":59,"phone":25,"phoneExt":25,"email":25},"SUB_INVESTIGATOR",{"name":61,"role":59,"phone":25,"phoneExt":25,"email":25},"Mislav Mikus, dr.med.",{"name":63,"role":59,"phone":25,"phoneExt":25,"email":25},"Ana-Maria Liberati Prso, dr.med",{"type":65,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[67],{"name":68,"class":6},"Clinical Hospital Centre Zagreb","100587513","the-role-of-probiotics-in-the-treatment-of-endometriosis-prometrios-a-randomised-double-blinded-placebo-controlled-cross-over-trial-100587513",false,"NCT06929364","The Role of Probiotics in the Treatment of Endometriosis (ProMetrioS): a Randomised Double-blinded Placebo-controlled Cross-over Trial","ProMetrioS","Minimum Age: - Maximum Age: 35 Years Sex: Female Gender Based: Ye - only women can participate in this study Accepts Healthy Volunteers: No\n\nInclusion Criteria:\n\n* adult subjects with stage III or IV endometriosis diagnosis confirmed by biopsy\n\nExclusion Criteria:\n\n* Age \\> 35 years\n* Immunocompromised patients\n* Patients with chronic inflammatory diseases (e.g., autoimmune disorders)\n* Pregnancy\n* Use of supplements and foods with probiotics\n* Use of immunosuppressant, antibiotic, proton pump inhibitors and corticosteroid drugs\n* Use of probiotics product less than one month before start of study or during study","FEMALE","35 Years",{"count":79,"type":80},40,"ESTIMATED","INTERVENTIONAL",[83],"NA","ProMetrioS is a randomised blinded placebo-controlled cross-over trial investigating the effect of specific multistrain probiotics in patients with endometriosis. The aim of this clinical trial is to determine whether probiotic treatment can significantly modulate gut microbiome composition and functionality in endometriosis patients, specifically parameters associated with the estrobolome.",[86,87],"Endometriosis","Probiotics",[89,90,91],"endometriosis","probiotics","microbiome","2025-04-14",{"date":94,"type":95},"2025-04-16","ACTUAL",{"date":97,"type":95},"2024-11-01",{"date":99,"type":80},"2025-11-30",{"name":5,"class":6},1]