[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100544824":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":18,"locations":28,"responsibleParty":47,"collaborators":49,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":10,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":10,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Kolding Sygehus","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Nephrotic syndrome",null,"Patients with nephrotic syndrome (n=32). Blood samples and 24 hour urine samples will be obtained an all participants. Kidney biopsy will be used from 11 test persons, whos been subjected to kidney biopsy unrelated to the research project.\n\n3",{"label":13,"type":10,"description":14,"interventionNames":10},"Kidney healthy controls","Patient with normal kidney function and no proteinuria (n=32). Blood samples and 24 hour urine samples will be obtained an all participants.",{"label":16,"type":10,"description":17,"interventionNames":10},"Kidney biopsy control","Patients without proteinuria who is subjected to kidney biopsy regardless of the research project.",[19,24],{"name":20,"role":21,"phone":22,"phoneExt":10,"email":23},"Rikke Z Langkilde, MD, phd","CONTACT","004576362554","rikke.zachar.langkilde@rsyd.dk",{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},"Anne D Thuesen, MD, phd","004576360555","Anne.Daugaard.Thuesen2@rsyd.dk",[29],{"facility":30,"status":31,"city":32,"state":10,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Kolding Sygehus, Lillebælt Hospital","RECRUITING","Kolding","6000","Denmark","DK",{"type":37,"coordinates":38},"Point",[39,40],9.47216,55.4904,{"lat":40,"lon":39},[43,45],{"name":44,"role":21,"phone":22,"phoneExt":10,"email":10},"Rikke Z Langkilde, md, phd",{"name":46,"role":21,"phone":26,"phoneExt":10,"email":27},"Anne D Thuesen, md, phd",{"type":48,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[50,52],{"name":51,"class":6},"Odense University Hospital",{"name":53,"class":6},"Vejle Hospital","100544824","the-role-of-proprotein-convertase-subtilisinkexin-type-9-in-kidney-damage-in-nephrotic-syndrom-100544824",false,"NCT06373913","The Role of Proprotein-convertase-subtilisin\u002FKexin-type 9 in Kidney Damage in Nephrotic Syndrom","PCSK9","Inclusion Criteria:\n\n* 18 years old\n* Patients admitted to the Medical Department and\u002For the Medical Emergency Department, Kolding Sygehus.\n\nExclusion Criteria:\n\n* Refusal to give informed consent\n* Treatment with PCSK9 inhibitors\n* Any acute or chronic condition that would limit the ability of the patient to participate in the study\n* Control group: proteinuria","ALL","18 Years",{"count":64,"type":65},75,"ESTIMATED","OBSERVATIONAL","Nephrotic syndrome (NS) is characterized by gross proteinuria (\\>3.5 g\u002Fday), hypoalbuminaemia, edema and often hyperlipidemia. Hyperlipidemia is correlated with increased morbidity and mortality.\n\nThe study aim is to investigate the role of the protein convertase subtilisin\u002Fkexin type 9 (PCSK9) in hyperlipidemia of NS, which has been suggested to play an important role. This is done by testing the following hypotheses:\n\n1. PCSK9 is increased in patients with NS and hyperlipidemia compared to kidney-healthy controls\n2. The level of PCSK9 in plasma correlates to the degree of proteinuria.\n3. PCSK9 i increased in the kidney tissue of patients with NS\n\nThe study will compare plasma levels of PCSK9 in correlation with degree of protein in the urine between test persons with NS and kidney healthy controls. Furthermore the investigators will study the the degree of PCSK9 in the kidney in biopsies obtained from test persons with nephrotic syndrome and test persons without proteinuria.",[69,70],"Hyperlipidemias","Nephrotic Syndrome","2025-09-02",{"date":73,"type":74},"2025-09-09","ACTUAL",{"date":76,"type":74},"2023-06-01",{"date":78,"type":65},"2028-07-30",{"name":5,"class":6},1]