[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100534856":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":25,"locations":35,"responsibleParty":52,"collaborators":18,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":18,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":18,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":18,"overallStatus":38,"whyStopped":18,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Guangdong Provincial People's Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Autoblood transfusion + leukocyte filter group","EXPERIMENTAL","In our department open surgery is considered as the standard procedure. The patients underwent open surgery, with autologous blood transfusion combined with a leukocyte filter. Blood transfusion based on bleeding during surgery.",[13],"Procedure: Autoblood transfusion",{"label":15,"type":16,"description":17,"interventionNames":18},"Allogeneic blood transfusion group","NO_INTERVENTION","In our department open surgery is considered as the standard procedure. The patients receives open surgery with allogeneic blood transfusion. Blood transfusion based on bleeding during surgery.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"PROCEDURE","Autoblood transfusion","Through a negative pressure suction device, the patient's blood that flows out during surgery is collected into a blood storage filter. During the suction process, it is mixed with an appropriate anticoagulant and passed through multiple layers of filters. When the volume of recovered blood reaches a certain level, it is continuously (or intermittently) centrifuged. Using a high-speed centrifugal blood recovery tank, the red blood cells are separated, and the plasma, waste, cell fragments, anticoagulants, and harmful components are diverted into a waste bag. A large amount of saline is used to repeatedly wash, purify, and concentrate the red blood cells. Finally, the concentrated red blood cells are prepared into a 70% red blood cell suspension with saline and stored in a collection bag for transfusion back to the patients. Open surgery is considered as the standard procedure for metastatic spinal cord compression",[9],[26,31],{"name":27,"role":28,"phone":29,"phoneExt":18,"email":30},"Yu Zhang, Ph.D.","CONTACT","8613602744495","luck_2001@126.com",{"name":32,"role":28,"phone":33,"phoneExt":18,"email":34},"Guoqing Zhong, M.D.","8613417005047","gqzhong@foxmail.com",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Guangdong provincial people's hospital","RECRUITING","Guangzhou","Guangdong","516008","China","CN",{"type":45,"coordinates":46},"Point",[47,48],113.25,23.11667,{"lat":48,"lon":47},[51],{"name":32,"role":28,"phone":18,"phoneExt":18,"email":34},{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Yu Zhang, PhD","Chief of Orthopedic Oncology","100534856","the-safety-and-efficacy-of-autologous-transfusion-in-spinal-surgery-for-lung-cancer-with-spinal-metastasis-100534856",false,"NCT06244264","The Safety and Efficacy of Autologous Transfusion in Spinal Surgery for Lung Cancer With Spinal Metastasis","A Single-center, Prospective, Randomized Controlled Study of the Safety and Efficacy of Autologous Transfusion in Spinal Surgery for Lung Cancer With Spinal Metastasis","Inclusion Criteria:\n\n* The age range is 18-75 years old;\n* The pathological diagnosis was lung cancer and spinal metastatic tumor;\n* Expected survival \\> 3 months, can tolerate surgery;\n* Unstable spine; And\u002For spinal cord nerve compression, nerve function; Progressive decline, palliative spinal open decompression surgery\n* Patients with intraoperative\u002Fpostoperative Hb\\\u003C90 g\u002FL or other conditions requiring blood transfusion\n\nExclusion Criteria:\n\n* Serious heart dysfunction or heart failure, diagnosed blood system diseases, coagulation disorders;\n* Severe renal insufficiency or need hemodialysis treatment;\n* Sepsis or septicemia;\n* Unable to obtain consent from the patient or family.","ALL","18 Years","75 Years",{"count":67,"type":68},118,"ESTIMATED","INTERVENTIONAL",[71],"NA","The goal of this single-center prospective randomized controlled trial is to test and compare the safety and effectiveness of autologous blood transfusion in spinal surgery for lung cancer spinal metastases. The main questions it aims to answer are:\n\n* Does autologous blood transfusion increase the incidence of new metastases?\n* Does autologous blood transfusion affect postoperative hemoglobin levels and the number of circulating tumor cells in the blood?\n* Can autologous blood transfusion reduce the rate of allogeneic transfusion during and after surgery for spinal metastases?",[74,75,76,77,78],"Spinal Metastases","Blood Transfusion Complication","Lung Cancer","Surgery","Autologous Blood Transfusion","2024-07-11",{"date":81,"type":82},"2024-07-12","ACTUAL",{"date":84,"type":82},"2024-03-15",{"date":86,"type":68},"2027-12-31",{"name":5,"class":6},1]