[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633807":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":27,"centralContacts":32,"locations":37,"responsibleParty":56,"collaborators":21,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":21,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":83,"overallStatus":88,"whyStopped":21,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Xi'an Honghui Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Preoperative Diagnostic SINRB for Responsible Compressed Nerve Root(RCNR) Localization","EXPERIMENTAL","All enrolled subjects will undergo the same standardized surgical procedure.\n\n* For patients with a single suspected lesion and RCNR (typically with ambiguous imaging findings), 2 separate SINRBs are performed (firstly at a non-responsible control root, then at the suspected RCNR) to rule out placebo effect and non-lumbar pain sources. If ≥50% pain relief occurs after the first block, the second SINRB is given the next day after local anesthetic clearance, and patients compare pain relief differences between the two sessions. If relief is less than 50%, the second SINRB is delivered after a 20-minute interval.\n* For patients with multiple nerve roots compressed, 1 SINRB is performed at the target nerve root to confirm that single-level surgical decompression can achieve complete pain relief. If complete pain relief or resolution of motor dysfunction is not achieved after the first injection, a second SINRB will be administered to an alternative suspected root to identify the true RCNR.",[13,14],"Diagnostic Test: Selective Intraperineural Nerve Root Block(SINRB)","Procedure: single-level lumbar decompression surgery",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DIAGNOSTIC_TEST","Selective Intraperineural Nerve Root Block(SINRB)","The patient was placed in a standard prone position. The cutaneous puncture point was confirmed via large C-arm oblique fluoroscopy with the projection angle strictly consistent with the preoperative protocol.All puncture manipulations were completed by an experienced spinal surgeon. Under intermittent fluoroscopic guidance, the puncture trajectory was adjusted to keep the needle parallel to the fluoroscopic beam, followed by slow needle advancement until radiating pain was evoked in the patient. The needle was further advanced approximately 1 mm, and 0.2 mL contrast medium was injected subsequently. The visualization of a linear streak shadow within the nerve root confirmed intraneural positioning. The needle was fixed in situ, and 0.5 mL lidocaine was injected.",[9],null,{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":21},"PROCEDURE","single-level lumbar decompression surgery","All patients underwent single-level lumbar surgery with either endoscopic or conventional open single nerve root decompression, and postoperative anteroposterior and lateral lumbar radiographs were routinely obtained for imaging evaluation.",[9],[28],{"name":29,"affiliation":30,"role":31},"Lingjiang Li, Attending physician","Xi'an Honghui Hospital, Xi'an, Shaanxi Province, China","PRINCIPAL_INVESTIGATOR",[33],{"name":29,"role":34,"phone":35,"phoneExt":21,"email":36},"CONTACT","+86 29-83661911","lilingjiang11@126.com",[38],{"facility":39,"status":21,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Xi'an Honghui Hospital (North Campus)","Xi'an","Shaanxi","710026","China","CN",{"type":46,"coordinates":47},"Point",[48,49],108.92861,34.25833,{"lat":49,"lon":48},[52],{"name":53,"role":34,"phone":54,"phoneExt":21,"email":55},"Ziqiang Yan","+86 29-86520907","honghuixiaozhao@163.com",{"type":31,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"Lingjiang Li","Attending Physician","100633807","the-selective-intraperineural-nerve-root-block-study-100633807",false,"NCT07531485","The Selective Intraperineural Nerve Root Block Study","Feasibility, Safety and Diagnostic Accuracy of Selective Intraperineural Nerve Root Block for Identifying Compressed Nerve Root in Lumbosacral Radicular Pain. A Prospective Cohort Study","SINRBS","Inclusion Criteria\n\n* Unilateral sciatica \\>1 month with activity\u002Fdaily life impairment.\n* Suspected L5\u002FS1 root compression at L4-5\u002FL5-S1 with unconfirmed pain correlation, including disc herniation (MSU 1-B\u002F1-A\u002F2-A), lateral recess\u002Fforaminal stenosis (Lee grade 2\u002F3), atypical sciatica, or imaging-exam inconsistency.\n* Candidates for single-segment, single-root lumbar decompression, electing surgery after informed consent.\n\nExclusion Criteria\n\n* No significant pre-SINRB\u002Fsurgery pain, or weakness\u002Fnumbness as primary symptom.\n* Unidentifiable responsible compressed nerve root (RCNR) per surgery.\n* Suspected compression of the same nerve root at more than one segment.\n* Pregnancy, active malignancy, or surgical contraindications.\n* Inability to cooperate with assessment due to comorbidities or dysfunction.","ALL","18 Years","90 Years",{"count":71,"type":72},80,"ESTIMATED","INTERVENTIONAL",[75],"NA","Before lumbosacral decompression surgery for radicular pain, selective nerve root block(SNRB) is a common procedure to identify the responsible compressed nerve root(RCNR) and predict surgical outcomes. However, the diagnostic accuracy of conventional SNRB is unsatisfactory, especially in terms of specificity. The main limitation is the uncontrolled distribution of anesthetics during injection: when anesthetics spread to surrounding soft tissues instead of acting directly on the RCNR, false-negative results may occur with persistent radicular pain; when anesthetics diffuse to two or more nerve roots including the RCNR, false-positive results may occur even if a normal nerve root is punctured, leading to misdiagnosis.\n\nThis study aims to evaluate the diagnostic accuracy of a novel three-dimensional computed tomography multiplanar volume reconstruction (3D-CT MPVR) guided selective intraperineural nerve root block(SINRB) for identifying the RCNR in patients with lumbosacral radicular pain. The investigators hypothesize that this technique will achieve higher diagnostic specificity and overall accuracy than conventional SNRB, by ensuring anesthetics are delivered directly to the target nerve root. This improvement will help clinicians make more accurate surgical plans, achieve better targeted decompression, and ultimately improve postoperative pain relief and functional recovery for patients.\n\nThe main research questions to be addressed in this study are:\n\n* What is the procedural success rate of SINRB?\n* Whether SINRB may cause clinically detectable nerve injury?\n* Whether sciatica is relieved after SINRB when only the responsible compressed nerve root is blocked?\n* Whether sciatica is relieved after SINRB when only a normal unaffected nerve root is blocked?\n\nParticipants will:\n\n* Undergo one or two SINRB procedures and a single-level lumbar decompression surgery\n* Get assessment of pain, mobility disorder and neurological function",[78,79,80,81,82],"Radiculopathy Lumbar","Radiculopathy Sacral","Radiculopathy Multiple Sites","Herniated Disc","Foraminal Stenosis",[84,85,86,87],"intraperineural","3D-CT MPVR","diagnostic selective nerve root block","lumbosacral radiculopathy","NOT_YET_RECRUITING","2026-04-11",{"date":91,"type":92},"2026-04-15","ACTUAL",{"date":94,"type":72},"2026-04-13",{"date":96,"type":72},"2027-01-01",{"name":5,"class":6},1]