[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100462190":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":28,"locations":38,"responsibleParty":119,"collaborators":10,"id":121,"slug":122,"hasResults":123,"nctId":124,"briefTitle":125,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":123,"sex":128,"minAge":129,"maxAge":10,"enrollmentInfo":130,"targetDuration":133,"studyType":134,"phases":10,"briefSummary":135,"conditions":136,"keywords":140,"overallStatus":41,"whyStopped":10,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":153},{"fullName":5,"class":6},"Guy's and St Thomas' NHS Foundation Trust","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Retrospective Cohort (ICD-10)",null,"All participants with stroke according to WHO ICD-10 definition registered on the SLSR prior to the protocol change in April 2022 will be followed up by interview at 3 months, 1 year, and 5, 10 and 15 years after stroke.",[13],"Other: Follow-up interview",{"label":15,"type":10,"description":16,"interventionNames":17},"Prospective Cohort (ICD-11)","All participants with stroke according to WHO ICD-11 definition registered on the SLSR following the protocol change in April 2022 will be followed up by interview at 3 months and then annually up to 5 years.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Follow-up interview","All participants will be followed up at defined time points post-stroke by face-to-face or telephone interview or postal questionnaire.",[15,9],[24],{"name":25,"affiliation":26,"role":27},"Iain Marshall","King's College London, UK","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},"Eva S Emmett","CONTACT","+44 20 7848 6613","eva.s.emmett@kcl.ac.uk",{"name":35,"role":31,"phone":36,"phoneExt":10,"email":37},"Matthew O'Connell","+44 20 7848 6318","matthew.o'connell@kcl.ac.uk",[39,57,68,78,88,99,109],{"facility":40,"status":41,"city":42,"state":10,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Barts Health NHS Trust","RECRUITING","London","E1 2ES","United Kingdom","UK",{"type":47,"coordinates":48},"Point",[49,50],-0.12574,51.50853,{"lat":50,"lon":49},[53,55],{"name":54,"role":31,"phone":32,"phoneExt":10,"email":33},"Eva Emmett",{"name":56,"role":27,"phone":10,"phoneExt":10,"email":10},"Alexandra Andrews",{"facility":58,"status":59,"city":42,"state":10,"zip":60,"country":44,"countryCode":45,"cosmosGeoPoint":61,"geoPoint":63,"contacts":64},"University College London hospitals NHS Foundation trust","NOT_YET_RECRUITING","NW1 2PG",{"type":47,"coordinates":62},[49,50],{"lat":50,"lon":49},[65,66],{"name":54,"role":31,"phone":32,"phoneExt":10,"email":33},{"name":67,"role":27,"phone":10,"phoneExt":10,"email":10},"David Werring",{"facility":69,"status":41,"city":42,"state":10,"zip":70,"country":44,"countryCode":45,"cosmosGeoPoint":71,"geoPoint":73,"contacts":74},"Guy's and St Thomas' NHS Foundation trust","SE1 7EH",{"type":47,"coordinates":72},[49,50],{"lat":50,"lon":49},[75,76],{"name":30,"role":31,"phone":32,"phoneExt":10,"email":33},{"name":77,"role":27,"phone":10,"phoneExt":10,"email":10},"Ajay Bhalla",{"facility":79,"status":41,"city":42,"state":10,"zip":80,"country":44,"countryCode":45,"cosmosGeoPoint":81,"geoPoint":83,"contacts":84},"King's College hospital NHS Foundation Trust","SE5 9RS",{"type":47,"coordinates":82},[49,50],{"lat":50,"lon":49},[85,86],{"name":54,"role":31,"phone":32,"phoneExt":10,"email":33},{"name":87,"role":27,"phone":10,"phoneExt":10,"email":10},"Laszlo Sztriha",{"facility":89,"status":59,"city":42,"state":10,"zip":90,"country":44,"countryCode":45,"cosmosGeoPoint":91,"geoPoint":93,"contacts":94},"Chelsea and Westminster Hospital NHS Foundation Trust","Sw10 9NH",{"type":47,"coordinates":92},[49,50],{"lat":50,"lon":49},[95,97],{"name":54,"role":31,"phone":96,"phoneExt":10,"email":33},"+44 020 7848 6613",{"name":98,"role":27,"phone":10,"phoneExt":10,"email":10},"Salwa Elmamoun",{"facility":100,"status":41,"city":42,"state":10,"zip":101,"country":44,"countryCode":45,"cosmosGeoPoint":102,"geoPoint":104,"contacts":105},"St George's University Hospitals NHS Foundation Trust","SW17 0QT",{"type":47,"coordinates":103},[49,50],{"lat":50,"lon":49},[106,107],{"name":54,"role":31,"phone":32,"phoneExt":10,"email":33},{"name":108,"role":27,"phone":10,"phoneExt":10,"email":10},"Gillian Cluckie",{"facility":110,"status":59,"city":42,"state":10,"zip":111,"country":44,"countryCode":45,"cosmosGeoPoint":112,"geoPoint":114,"contacts":115},"Imperial College Healthcare NHS trust","W2 1BL",{"type":47,"coordinates":113},[49,50],{"lat":50,"lon":49},[116,117],{"name":54,"role":31,"phone":32,"phoneExt":10,"email":33},{"name":118,"role":27,"phone":10,"phoneExt":10,"email":10},"Soma Banerjee",{"type":120,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100462190","the-south-london-stroke-register-improving-the-lives-of-stroke-survivors-with-data-100462190",false,"NCT05298436","The South London Stroke Register: Improving the Lives of Stroke Survivors With Data","SLSR","Inclusion Criteria:\n\n1. Confirmed stroke (WHO ICD-11 clinical definition)- cerebral ischaemic stroke, primary intracerebral haemorrhage, subarachnoid haemorrhage and stroke not known if ischaemic or haemorrhagic. Formerly defined Transient Ischaemic Attacks with CT\u002FMRI evidence of cerebrovascular disease are classified as stroke under this definition.\n2. Living in the study area at the time of the first stroke.\n3. First stroke since 1st January 1995 for enrolled participants. First stroke since 1st April 2022 for updated definition.\n\nExclusion Criteria:\n\n1. First ever stroke is before 1st January 1995\n2. Patients' main residence at the time of first stroke is outside the study area.\n3. Focal neurological signs resolved within 24 hours and no CT\u002FMRI scan reports evidence of cerebrovascular disease (i.e. transient ischaemic attack)\n4. CT\u002FMRI scans positive for cerebrovascular disease but absence of related focal neurological deficits (asymptomatic cerebrovascular disease)\n5. brain lesion other than stroke causes the acute symptoms such as cerebral tumour or metastases","ALL","18 Years",{"count":131,"type":132},2000,"ESTIMATED","15 Years","OBSERVATIONAL","The South London Stroke Register (SLSR) is an observational population based registry, combining a population incidence study of stroke events in a geographically defined area of South London and a cohort study of these patients followed up over time. The SLSR has been continually ongoing since January 1995 using the WHO ICD-10 definition of stroke. From April 2022, SLSR will use the new ICD-11 definition for case identification to establish a new prospective cohort of patients identified according to the new definition.\n\nFollow up of the existing retrospective cohort of current patients will continue, providing data on long term outcomes of stroke through a program of regular patient interviews up to 15 years after stroke. Outcome measures include health outcomes, such as stroke mortality and recurrence, and measures of activities of daily living, quality of life and mental health (cognition, anxiety, depression).\n\nThe new data collection will include newly selected scales to best capture variation in key health domains and long term outcomes.\n\nThe change to ICD-11 is expected to lead to an increase in the incidence of stroke and a reduction in the average severity, but the effects of this change have not yet been measured in any population internationally. There is a need for a high quality population-based stroke incidence study to address this gap. Similarly, the factors determining the health of long-term stroke survivors can only be understood using a long running observational cohort study.\n\nThe overall purpose of this research is to continue and develop the SLSR data collection and analysis to address the needs of stroke patients in the 2020s. The current programme was funded to address the following objectives as part of a broader NIHR programme grant on using data to improve the lives of stroke survivors:\n\n* Understand the impact of the ICD-11 new definition of stroke\n* Define the outcomes and needs of long-term stroke survivors\n* Support stroke survivors and stakeholders with these detailed data and analyses\n* Describe the use of formal, informal, and social care services up to 15 years after stroke\n* Asses the influence of formal, informal, and social care use on stroke recovery and generate patient-level total costs up to 15 years after stroke",[137,138,139],"Stroke","Subarachnoid Hemorrhage","Intracranial Hemorrhages",[141,142,143],"Registries","Epidemiology","Cohort study","2024-03-05",{"date":146,"type":147},"2024-03-06","ACTUAL",{"date":149,"type":147},"2022-04-01",{"date":151,"type":132},"2026-12",{"name":5,"class":6},7]