[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632283":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":24,"centralContacts":27,"locations":33,"responsibleParty":103,"collaborators":24,"id":107,"slug":108,"hasResults":109,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":109,"sex":115,"minAge":116,"maxAge":24,"enrollmentInfo":117,"targetDuration":24,"studyType":120,"phases":121,"briefSummary":123,"conditions":124,"keywords":127,"overallStatus":66,"whyStopped":24,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":142},{"fullName":5,"class":6},"Region Skane","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Preoperative dental screening","EXPERIMENTAL","Preoperative dental examination with treatment if clinically indicated.",[13],"Other: Preoperative dental screening",{"label":15,"type":16,"description":17,"interventionNames":18},"No preoperative dental screening","ACTIVE_COMPARATOR","No routine dental screening prior to valve intervention.",[19],"Other: No preoperative dental screening",[21,25],{"type":6,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"Dental examination prior to valve intervention; treatment performed if indicated.",[9],null,{"type":6,"name":15,"description":17,"armGroupLabels":26,"otherNames":24},[15],[28],{"name":29,"role":30,"phone":31,"phoneExt":24,"email":32},"Patrik Gilje, MD-PhD","CONTACT","+46 (0)46171819","patrik.gilje@skane.se",[34,51,64,78,91],{"facility":35,"status":36,"city":37,"state":24,"zip":24,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Sahlgrenska University Hospital","NOT_YET_RECRUITING","Gothenburg","Sweden","SE",{"type":41,"coordinates":42},"Point",[43,44],11.96679,57.70716,{"lat":44,"lon":43},[47],{"name":48,"role":30,"phone":49,"phoneExt":24,"email":50},"Anders Jeppsson, Professor","046313421000","anders.jeppsson@vgregion.se",{"facility":52,"status":36,"city":53,"state":24,"zip":24,"country":38,"countryCode":39,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"Linköping University Hospital","Linköping",{"type":41,"coordinates":55},[56,57],15.62157,58.41086,{"lat":57,"lon":56},[60],{"name":61,"role":30,"phone":62,"phoneExt":24,"email":63},"Farkas Vanky, Professor","+4610-1030000","farkas.vanky@regionostergotland.se",{"facility":65,"status":66,"city":67,"state":24,"zip":24,"country":38,"countryCode":39,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Skane University Hospital","RECRUITING","Lund",{"type":41,"coordinates":69},[70,71],13.19321,55.70584,{"lat":71,"lon":70},[74],{"name":75,"role":30,"phone":76,"phoneExt":24,"email":77},"Anneli Olsson, RN-PhD","+46(0)46173723","anneli.t.olsson@skane.se",{"facility":79,"status":36,"city":80,"state":24,"zip":24,"country":38,"countryCode":39,"cosmosGeoPoint":81,"geoPoint":85,"contacts":86},"Örebro University Hospital","Örebro",{"type":41,"coordinates":82},[83,84],15.2066,59.27412,{"lat":84,"lon":83},[87],{"name":88,"role":30,"phone":89,"phoneExt":24,"email":90},"Örjan Friberg, Ass prof","+4619-602 10 00","orjan.friberg@regionorebrolan.se",{"facility":92,"status":36,"city":93,"state":24,"zip":24,"country":38,"countryCode":39,"cosmosGeoPoint":94,"geoPoint":98,"contacts":99},"Karolinska University Hospital","Stockholm",{"type":41,"coordinates":95},[96,97],18.06871,59.32938,{"lat":97,"lon":96},[100],{"name":101,"role":30,"phone":102,"phoneExt":24,"email":24},"Ulrik Sartipy, Professor","+46812370000",{"type":104,"investigatorFullName":105,"investigatorTitle":106,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Patrik Gilje","Principal Investigator","100632283","the-study-tests-if-preoperative-dental-screening-is-superior-to-no-preoperative-dental-screening-in-improving-the-outcome-of-patients-undergoing-surgical-cardiac-valve-replacement-or-transcatheter-cardiac-valve-implantation-100632283",false,"NCT07511673","The Study Tests if Preoperative Dental Screening is Superior to no Preoperative Dental Screening in Improving the Outcome of Patients Undergoing Surgical Cardiac Valve Replacement or Transcatheter Cardiac Valve Implantation.","SMILE: A Randomized Trial of Preoperative Dental Screening for the Prevention of Endocarditis, Reoperation or Death in Patients Undergoing Surgical or Transcatheter Cardiac Valve Intervention.","SMILE","Inclusion Criteria:\n\n* Age ≥18 years\n* Accepted for cardiac valve intervention\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Previous or ongoing infective endocarditis\n* Urgent surgery\n* Pain from loose tooth\u002Fteeth\n* Immunosuppressive therapy (excluding corticosteroids)\n* Inability to provide informed consent\n* Expected loss to follow-up","ALL","18 Years",{"count":118,"type":119},1300,"ESTIMATED","INTERVENTIONAL",[122],"NA","This randomized, multicenter, open-label trial evaluates whether preoperative dental screening improves outcomes in patients undergoing surgical or transcatheter cardiac valve intervention. Participants are randomized 1:1 to preoperative dental screening or no screening. The primary outcome is time to first occurrence of all-cause death, redo-intervention of the index valve, or definite infective endocarditis within 2 years. The study uses registry-based follow-up to ensure complete outcome ascertainment.",[125,126],"Infective Endocarditis (IE)","Heart Valve Disease",[128,129,130,131,132],"Dental screening","valve intervention","endocarditis","TAVI","valve surgery","2026-05-15",{"date":135,"type":136},"2026-05-19","ACTUAL",{"date":138,"type":136},"2026-05-06",{"date":140,"type":119},"2036-12-01",{"name":5,"class":6},5]