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Primary unifocal or multifocal invasive breast cancer T1-T2.\n2. Clinically N0.\n3. Macrometastasis (\\>2mm) in 1-2 lymph nodes at sentinel node biopsy.\n4. Oral and written consent.\n5. Age ≥ 18 years.\n6. All resection margins are tumor free (no tumor on ink).\n7. Primary tumor ER-positive, HER2-negative.\n\nExclusion Criteria:\n\n1. Regional or distant metastases outside the ipsilateral axilla.\n2. Previous RT towards the planned target area, i.e. the ipsilateral chest\u002Flymph nodes.\n3. Neoadjuvant systemic therapy.\n4. Axillary lymph node dissection or other previous axillary surgery on the affected side.\n5. Prior history of invasive breast cancer.\n6. Pregnancy.\n7. Bilateral invasive breast cancer.\n8. Contraindication for radiotherapy or systemic treatment.\n9. Inability to absorb or understand the contents of the informed consent form; for example, through disability, inadequate language skills or dementia.\n10. 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Radiotherapy is still given to the remaining breast after breast conserving surgery, but no radiotherapy is given after mastectomy.\n\nSample size: 1350 patients\n\nPrimary end-point: Recurrence free survival at five years.\n\nGene expression analysis: For all patients gene expression analysis for the gene signatures ARTIC, POLAR and OncotypeDX will be performed and related to risk of recurrence and benefit of adjuvant radiotherapy.",[367],"Breast Cancer",[369,370,371,372,373],"breast cancer","radiotherapy","gene expression analysis","adjuvant breast cancer treatment","regional breast cancer treatment","2026-05-08",{"date":376,"type":377},"2026-05-11","ACTUAL",{"date":379,"type":377},"2023-03-17",{"date":381,"type":361},"2033-12-31",{"name":5,"class":6},30]