[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587781":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":61,"collaborators":26,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":26,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":26,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":47,"whyStopped":26,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Chulalongkorn University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Curcumin Group","EXPERIMENTAL","Curcumin nanogels applied 3 times daily for 4 weeks",[13],"Drug: Curcumin in Nanogels",{"label":15,"type":16,"description":17,"interventionNames":18},"Fluocinolone Paste Group","ACTIVE_COMPARATOR","0.1% Fluocinolone acetonide oral paste applied 3 times daily for 4 weeks",[19],"Drug: 0.1% Fluocinolone Acetonide Oral Paste",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Curcumin in Nanogels","Participants will apply curcumin nanogels to affected oral areas three times daily for 4 weeks.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"0.1% Fluocinolone Acetonide Oral Paste","Participants will apply 0.1% fluocinolone acetonide oral paste to the affected oral mucosa three times daily for 4 weeks. This corticosteroid paste is the standard treatment for oral lichen planus.",[15],[32],{"name":33,"affiliation":34,"role":35},"Pirawish Limlawan, D.D.S., Ph.D.","Faculty of Dentistry, Chulalongkorn University","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Tossapol Maneethorn, D.D.S.","CONTACT","086-9253975","comeblack_ubama@hotmail.com",{"name":33,"role":39,"phone":43,"phoneExt":26,"email":44},"084-090-3309","pirawish@gmail.com",[46],{"facility":34,"status":47,"city":48,"state":26,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Bangkok","10400","Thailand","TH",{"type":53,"coordinates":54},"Point",[55,56],100.50144,13.75398,{"lat":56,"lon":55},[59],{"name":38,"role":39,"phone":60,"phoneExt":26,"email":41},"+66 86 925 3975",{"type":62,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100587781","the-therapeutic-effect-of-curcumin-in-nanogels-compared-to-01-fao-in-the-management-of-oral-lichen-planus-100587781",false,"NCT06932848","The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% FAO in the Management of Oral Lichen Planus","The Therapeutic Effect of Curcumin in Nanogels Compared to 0.1% Fluocinolone Acetonide Oral Paste in the Management of Atrophic-Erosive Oral Lichen Planus","Inclusion Criteria:\n\n* Age 18 years or older\n* Ability to provide written informed consent\n* Clinically and histopathologically confirmed diagnosis of erosive or atrophic oral lichen planus (OLP)\n* Presence of symptoms (NRS pain score \\> 0 at baseline)\n* Ability to communicate and follow instructions\n* Willingness to apply oral paste treatment and comply with study protocol\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Current orthodontic treatment\n* Uncontrolled diabetes mellitus (HbA1c \\> 7% or FPG \\> 130 mg\u002FdL)\n* Use of anticoagulants or antiplatelet agents\n* Severe dry mouth (Challacombe score \\> 7)\n* History of gastric ulcers, duodenal ulcers, or gallstones\n* Presence of any active malignancy or infection\n* Use of topical\u002Fsystemic treatment for OLP in the past 2 weeks\n* Current use of immunosuppressants\n* Known allergy to corticosteroids or herbal agents such as turmeric\n* Diagnosis of oral lichenoid contact lesion or graft-versus-host disease (GVHD)\n* History of allogeneic bone marrow transplantation\n* Current smokers","ALL","18 Years",{"count":73,"type":74},30,"ESTIMATED","INTERVENTIONAL",[77],"NA","This randomized, double-blind clinical trial evaluates the therapeutic effects of curcumin in nanogels compared to 0.1% fluocinolone acetonide oral paste in the management of atrophic-erosive oral lichen planus (OLP). The study aims to determine whether curcumin nanogels, a natural treatment with enhanced bioavailability, are as effective and better tolerated than standard corticosteroid therapy.",[80],"Oral Lichen Planus",[82,83,84,85,86,87],"Atrophic-Erosive Oral Lichen Planus","Curcumin","Nanogels","Fluocinolone Acetonide","Mucosal Disease","Autoimmune Disease","2026-03-04",{"date":90,"type":91},"2026-03-06","ACTUAL",{"date":93,"type":91},"2025-06-01",{"date":95,"type":74},"2026-06-30",{"name":5,"class":6},1]