[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100566382":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":51,"collaborators":26,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":26,"enrollmentInfo":64,"targetDuration":26,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Second Xiangya Hospital of Central South University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Thrombectomy + PCI Arm","EXPERIMENTAL","This group will receive thrombectomy combined with percutaneous coronary intervention.",[13,14],"Procedure: Thrombectomy","Procedure: Percutaneous Coronary Intervention",{"label":16,"type":17,"description":18,"interventionNames":19},"PCI-only Arm","ACTIVE_COMPARATOR","PCI is an established treatment for STEMI, and you are comparing it to the experimental group that receives an additional thrombectomy procedure.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Thrombectomy","Manual thrombectomy followed by Percutaneous Coronary Intervention (PCI), a procedure involving mechanical removal of thrombus before stent placement in coronary arteries to restore blood flow in STEM",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Percutaneous Coronary Intervention","Percutaneous Coronary Intervention, involving balloon angioplasty and stent placement to open blocked coronary arteries in STEMI patients after thrombolysis.",[16,9],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Shenghua Zhou","CONTACT","073185292012","zhoushenghua@csu.edu.cn",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":26,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":26},"Department of General Surgery, The Second Xiangya Hospital of Central South University, No. 139, Middle Renmin Road, Changsha, 410011 Hunan, PR China","RECRUITING","Changsha","Hunan","China","CN",{"type":46,"coordinates":47},"Point",[48,49],112.97087,28.19874,{"lat":49,"lon":48},{"type":52,"investigatorFullName":33,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Director","100566382","the-thrombus-aspiration-during-pci-after-thrombolysis-in-stemi-100566382",false,"NCT06654453","The Thrombus Aspiration During PCI After Thrombolysis in STEMI","The Thrombus Aspiration During Percutaneous Coronary Intervention After Thrombolysis in ST-elevation Myocardial Infarction","Optimal","Inclusion Criteria:\n\n1. Diagnosed with STEMI.\n2. No contraindications for thrombolysis and has received thrombolytic treatment.\n3. Undergoing coronary angiography within 2 to 24 hours post-thrombolysis.\n4. Angiographic results confirm TIMI thrombus load ≥ 4 and residual stenosis \\> 50%.\n\nExclusion Criteria:\n\n1. Contraindications for thrombolysis.\n2. Cardiogenic shock.\n3. Need for coronary artery bypass grafting.\n4. Age less than 18 years.\n5. Life expectancy of less than 6 months.\n6. Unable to provide informed consent.","ALL","18 Years",{"count":65,"type":66},3500,"ESTIMATED","INTERVENTIONAL",[69],"NA","The goal of this clinical trial is to determine whether thrombus aspiration combined with percutaneous coronary intervention (PCI) improves clinical outcomes in ST-segment elevation myocardial infarction (STEMI) patients with high thrombus burden post-thrombolysis, compared to PCI alone. The study population includes 3500 STEMI patients, confirmed by diagnosis, who are transferred to PCI centers after receiving thrombolysis and have no contraindications to thrombolysis.The main questions it aims to answer are:\n\n1. Does thrombus aspiration reduce 30-day major adverse cardiovascular events (MACE), including cardiovascular death, recurrent myocardial infarction, stroke, or heart failure rehospitalization?\n2. Can thrombus aspiration improve microcirculation and clinical outcomes for high thrombus burden patients after thrombolysis? Researchers will compare patients randomly assigned to receive thrombus aspiration combined with PCI versus those who receive PCI alone to evaluate the effects on reducing MACE and improving clinical recovery.\n\nParticipants will:\n\nUndergo initial thrombolysis followed by transfer to PCI centers. Be randomly assigned in a 1:1 ratio to receive either thrombus aspiration combined with PCI or PCI alone.\n\nBe followed for 30 days post-treatment to assess MACE and other clinical outcomes.",[72],"ST-segment Elevation Myocardial Infarction",[74,75,76,77,78],"ST-segment elevation myocardial infarction","Thrombus aspiration","Percutaneous coronary intervention","High thrombus burden","Randomized controlled trial","2026-02-25",{"date":81,"type":82},"2026-02-27","ACTUAL",{"date":84,"type":82},"2024-11-01",{"date":86,"type":66},"2028-11-01",{"name":33,"class":6},1]