[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100574402":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":34,"locations":40,"responsibleParty":70,"collaborators":73,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":84,"minAge":85,"maxAge":25,"enrollmentInfo":86,"targetDuration":25,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":95,"overallStatus":43,"whyStopped":25,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa","NETWORK",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"MedDiet+ intervention","EXPERIMENTAL","The 12-week nutritional intervention includes a personalized dietary plan based on the MedDiet+ pattern, educational resources, food basket deliveries, and clinical culinary workshops, all developed and monitored weekly by registered dietitians. The nutritional plan includes the food portions of each food group in agreement with the MedDiet recommendations for the adult population, complemented with fermented foods including kefir (provided for daily consumption) and kombucha (provided for consumption 2x\u002Fweek).",[13],"Other: MedDiet+ intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"General dietary recommendations","ACTIVE_COMPARATOR","This group receives a flyer with general recommendations on a healthy diet based on the Portuguese brief guidance for healthy eating in primary health care at baseline",[19],"Other: General dietary recommendations",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"OTHER","Study arm will consume a Mediterranean like style diet enriched in fermented foods for 12 weeks",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Study arm will be given general healthy eating advice at baseline.",[15],[30],{"name":31,"affiliation":32,"role":33},"Catarina Sousa Guerreiro, RD PhD","Nutrition Lab, Faculty of Medicine, University of Lisbon","PRINCIPAL_INVESTIGATOR",[35],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Catarina Sousa Guerreiro, PhD","CONTACT","+351 217 999 474","cfguerreiro@medicina.ulisboa.pt",[41,61],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":45,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Unidade Local de Saude de Santa Maria","RECRUITING","Lisbon","Portugal","1649-035","PT",{"type":49,"coordinates":50},"Point",[51,52],-9.1498,38.72509,{"lat":52,"lon":51},[55,59],{"name":56,"role":37,"phone":57,"phoneExt":25,"email":58},"Ana Lopes, McS","+351210405814","cic@ulssm.min-saude.pt",{"name":60,"role":37,"phone":25,"phoneExt":25,"email":25},"Patrícia Costa-Reis, MD PhD",{"facility":62,"status":43,"city":44,"state":45,"zip":63,"country":45,"countryCode":47,"cosmosGeoPoint":64,"geoPoint":66,"contacts":67},"Faculdade Medicina de Lisboa","1800-268",{"type":49,"coordinates":65},[51,52],{"lat":52,"lon":51},[68],{"name":69,"role":37,"phone":38,"phoneExt":25,"email":39},"Catarina Sousa Guerreiro",{"type":33,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Ana Lopes","Centro Académico de Medicina de Lisboa",[74],{"name":75,"class":22},"Gulbenkian Institute for Molecular Medicine","100574402","the-triad-of-nutrition-intestinal-microbiota-and-rheumatoid-arthritis-tasty-100574402",false,"NCT06758817","The Triad of Nutrition, Intestinal Microbiota and Rheumatoid Arthritis (TASTY)","TASTY","Inclusion Criteria:\n\n* RA patients (ACR\u002FEULAR2010 criteria)\n* Age \\>18-years\n* Disease duration \\>1-year\n* Active disease (DAS28 \\> 2.6units)\n* On stable medication for 12 weeks\n* Low\u002Fmedium MedDiet adherence (PREDIMED\\\u003C10)\n* Willing to comply with study protocol\n\nExclusion Criteria:\n\n* Prednisolone dose ≥ 7.5 mg\u002Fday\n* Antibiotic therapy 4-weeks prior to baseline\n* Persistent use of NSAID's\n* Inflammatory or irritable bowel disease\n* Celiac disease\n* Chronic diarrhea\n* Diabetes\n* Other immune-mediated inflammatory diseases besides RA\n* Major organ dysfunction\n* Cancer diagnosed in the last five years\n* Health conditions which may difficult participation (cognitive impairment\u002Fpsychiatric disease)\n* Pregnant or lactating individuals",true,"ALL","18 Years",{"count":87,"type":88},100,"ESTIMATED","INTERVENTIONAL",[91],"NA","The main goal of this trial is to investigate whether a dietary intervention based on a typical Mediterranean Diet enriched with fermented foods (MedDiet+) can impact gut microbiota and RA-related outcomes.",[94],"Diet Interventions",[94,96],"rheumatoid arthritis","2024-12-27",{"date":99,"type":100},"2025-01-06","ACTUAL",{"date":102,"type":100},"2023-01-02",{"date":104,"type":88},"2025-12-31",{"name":5,"class":6},2]