[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100585672":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":10,"locations":32,"responsibleParty":76,"collaborators":10,"id":78,"slug":79,"hasResults":80,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":10,"eligibilityCriteria":84,"healthyVolunteers":80,"sex":85,"minAge":86,"maxAge":10,"enrollmentInfo":87,"targetDuration":10,"studyType":90,"phases":10,"briefSummary":91,"conditions":92,"keywords":10,"overallStatus":34,"whyStopped":10,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Sheffield Teaching Hospitals NHS Foundation Trust","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"No therapy intervention",null,"cMRI \\& TTE, no further intervention",[13],"Diagnostic Test: Advanced imaging",{"label":15,"type":10,"description":16,"interventionNames":17},"Therapy intervention","cMRI \\& TTE, SGLT-2 inhibitor therapy",[13,18],"Drug: SGLT-2 inhibitor",[20,28],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIAGNOSTIC_TEST","Advanced imaging","Cardiac MRI scan Transthoracic ECHO",[9,15],[26,27],"TTE","cMRI",{"type":29,"name":30,"description":30,"armGroupLabels":31,"otherNames":10},"DRUG","SGLT-2 inhibitor",[15],[33,59],{"facility":5,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Sheffield","South Yorkshire","S5 7AU","United Kingdom","UK",{"type":41,"coordinates":42},"Point",[43,44],-1.4659,53.38297,{"lat":44,"lon":43},[47,52,56],{"name":48,"role":49,"phone":50,"phoneExt":10,"email":51},"Helen Denney","CONTACT","07584187702","h.denney@nhs.net",{"name":53,"role":49,"phone":54,"phoneExt":10,"email":55},"Sam Walmsley","01142265932","Samantha.Walmsley@nhs.net",{"name":57,"role":58,"phone":10,"phoneExt":10,"email":10},"Rebecca Gosling","PRINCIPAL_INVESTIGATOR",{"facility":60,"status":61,"city":35,"state":10,"zip":62,"country":38,"countryCode":39,"cosmosGeoPoint":63,"geoPoint":65,"contacts":66},"University of Sheffield","NOT_YET_RECRUITING","S10 2TN",{"type":41,"coordinates":64},[43,44],{"lat":44,"lon":43},[67,71,75],{"name":68,"role":49,"phone":69,"phoneExt":10,"email":70},"Rebecca Gosling Dr Gosling","07971012988","r.gosling@sheffield.ac.uk",{"name":72,"role":49,"phone":73,"phoneExt":10,"email":74},"Abdallah Al-Mohammad Professor Al-Mohammad","01142434343","abdallah.al-mohammad@nhs.net",{"name":57,"role":58,"phone":10,"phoneExt":10,"email":10},{"type":77,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100585672","the-use-of-advanced-imaging-in-hfpef-100585672",false,"NCT06905405","The Use of Advanced Imaging in HFpEF","Assessing the Ability to Improve the Diagnosis of Heart Failure With Preserved Ejection Fraction Using Advanced Imaging Techniques","Inclusion Criteria:\n\n* Male or female \\> 18yrs of age.\n* Symptoms of dysponea on exertion.\n* NTproBNP \\>400 ng\u002FL in sinus rhythm (SR).\n* Baseline TTE demonstrating a dilated LA (LA\\>34 ml\u002Fm2), but that otherwise does not meet the current criteria for the diagnosis of HFpEF or HFrEF (preserved LV systolic function, Normal E\u002Fe', no evidence of LVH, Estimated PAP \\\u003C 35mmhg).\n\nExclusion Criteria:\n\n* Inability to give informed consent. History of HFrEF\n* contraindications to SGLT2 inhibitor (a history of type 1 diabetes mellitus, ketoacidosis, allergy to SGLT2 inhibitors, planned or current use of SGLT2 inhibitors or active genital infection).\n* Atrial Fibrillation.\n* Current history of anginal chest pain","ALL","18 Years",{"count":88,"type":89},40,"ESTIMATED","OBSERVATIONAL","Heart failure with preserved ejection fraction (HFpEF) causes symptoms of breathlessness and leg swelling. It is associated with significant number of hospital admissions and could lead to the patient's death. In HFpEF, the pumping function of the heart is normal but the heart is too stiff to fill properly. The first line investigation is an ultrasound of the heart (echocardiography). A number of parameters are assessed that indicate stiffness within the heart or raised pressures within the heart. However, most of these parameters lack sensitivity which can make HFpEF difficult to diagnose. The best test is to invasively measure the pressures in the heart at rest and with exercise in a procedure called heart catheterisation. However, this is invasive and not readily available. As a result, HFpEF is significantly under diagnosed meaning many patients do not get access to disease specific treatment that may improve symptoms and quality of life. There are a number of new imaging techniques that may help us to better identify HFpEF . However, it is not currently known how to best apply them in clinical practice.\n\nIn this study, the investigators will recruit patients presenting to the HF clinic at Sheffield Teaching Hospitals who have symptoms of HFpEF but whose diagnosis remains unclear after initial assessment. The impact of their symptoms will be assessed with the use of a quality of life (QoL) questionnaires and a six-minute walk test (6MWT). They will undergo advanced imaging with a specialist echocardiogram and a cardiac MRI scan. If they are found to have features of HFpEF, they will be started on disease specific treatment. All patients will be followed up after six months to see if they have any symptomatic or functional improvement. They will also undergo repeat imaging to see if there has been any change in the imaging parameters.",[93],"Heart Failure With Preserved Ejection Fraction (HFPEF)","2026-03-16",{"date":96,"type":97},"2026-03-18","ACTUAL",{"date":99,"type":97},"2025-08-05",{"date":101,"type":89},"2027-09-30",{"name":5,"class":6},2]