[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100418694":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":39,"responsibleParty":67,"collaborators":25,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":73,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":25,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":25,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Queen's University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active tDCS","ACTIVE_COMPARATOR","Transcranial Direct Current Stimulation: Soterix tDCS kit will be used to deliver the stimulation using two sponge electrodes soaked in a saline solution. The stimulation montage will comprise of left anodal Dorsal Lateral Prefrontal cortex (DLPFC) stimulation. The anodal electrode will be placed over the area corresponding to the left DLPFC (F5 of the EEG10-20 international system) and the reference (cathodal) electrode over the right supraorbital ridge. The active stimulation condition will use a constant current of 2mA, delivered via gradual increase and decrease over 10 seconds at the onset and offset of stimulation (current ramps), respectively. The duration a single tDCS session will be 20 minutes.",[13],"Device: Transcranial Direct Current Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham tDCS","SHAM_COMPARATOR","Sham Transcranial Direct Current Stimulation: Soterix tDCS kit will be used to deliver the sham stimulation using two sponge electrodes soaked in a saline solution. The sham stimulation montage will comprise of left anodal Dorsal Lateral Prefrontal cortex (DLPFC) stimulation for 10s only. The anodal electrode will be placed over the area corresponding to the left DLPFC (F5 of the EEG10-20 international system) and the reference (cathodal) electrode over the right supraorbital ridge. The sham tDCS is identical to the active tDCS except that the current will be delivered only in the first 10 seconds, after which the stimulation will cease but with the electrodes still in place throughout the session. The duration of each sham tDCS session will be 20 minutes.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Transcranial Direct Current Stimulation","non-invasive brain stimulator",[9,15],null,[27],{"name":28,"affiliation":5,"role":29},"Muhammad Ayub, MD","STUDY_CHAIR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Najat Khalifa, MD","CONTACT","+6135444900","nrk2@queensu.ca",{"name":37,"role":33,"phone":25,"phoneExt":25,"email":38},"Andrew Bickle, MD","arb12@queensu.ca",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Providence Care Hospital","RECRUITING","Kingston","Ontario","K7L 4X3","Canada","CA",{"type":49,"coordinates":50},"Point",[51,52],-76.48098,44.22976,{"lat":52,"lon":51},[55,56,58,61,63,65],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},{"name":32,"role":57,"phone":25,"phoneExt":25,"email":25},"PRINCIPAL_INVESTIGATOR",{"name":59,"role":60,"phone":25,"phoneExt":25,"email":25},"Andrew Bickle, FRCPC","SUB_INVESTIGATOR",{"name":62,"role":60,"phone":25,"phoneExt":25,"email":25},"Jessica Jones",{"name":64,"role":60,"phone":25,"phoneExt":25,"email":25},"Drury Andrew",{"name":66,"role":60,"phone":25,"phoneExt":25,"email":25},"Khan Mohammad",{"type":68,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Dr. Najat Khalifa","Principle Investigator","100418694","the-use-of-transcranial-direct-current-stimulation-tdcs-in-adults-with-developmental-disabilities-100418694",false,"NCT04732052","The Use of Transcranial Direct Current Stimulation (tDCS) in Adults With Developmental Disabilities","The Use of Transcranial Direct Current Stimulation (tDCS) to Reduce Impulsivity and Aggression in Adults With Developmental Disabilities: The tDCS-RIADD Randomized Controlled Trial Protocol","tDCS-RIADD","Inclusion Criteria:\n\n* Adults aged 18-64 years\n* Diagnosis of a developmental disability\n* History of one or more incidents of aggression in the last month\n* Consent to participate in the trial by the individual or their Substitute Decision Maker\n\nExclusion Criteria:\n\n* History of epilepsy or seizures\n* History of acquired brain injury\n* Having metal in the brain\u002Fskull, e.g. splinters, fragments or clips\n* Having a cochlear implant\n* Having an implanted neuro-stimulator (e.g. direct brain stimulation, epidural\u002Fsubdural stimulation, vagal nerve stimulation)\n* History of brain surgery of procedure\n* History of severe adverse reaction to tDCS\n* Having a cardiac pacemaker or intracardiac lines\n* Current alcohol or drug misuse\n* Having a sensitive scalp","ALL","18 Years","65 Years",{"count":83,"type":84},60,"ESTIMATED","INTERVENTIONAL",[87],"NA","Aggressive behaviours are highly prevalent among people with developmental disabilities, both in community and inpatient or residential settings, with adverse consequences for the individuals involved and others. Some predictive factors, particularly impulsivity, are dynamic with neurobiological underpinnings, and as such amenable to change or neuromodulation using non-invasive brain stimulation techniques. With this in mind, we designed an experimental protocol to determine the efficacy of transcranial Direct Current Stimulation (tDCS) as a non-invasive brain stimulation technique to reduce impulsivity and aggression associated with developmental disability.",[90],"Aggression","2025-03-21",{"date":93,"type":94},"2025-03-25","ACTUAL",{"date":96,"type":94},"2022-09-01",{"date":98,"type":84},"2028-12-31",{"name":69,"class":6},1]