[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581786":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":7,"responsibleParty":18,"collaborators":7,"id":20,"slug":21,"hasResults":22,"nctId":23,"briefTitle":24,"officialTitle":24,"acronym":7,"eligibilityCriteria":25,"healthyVolunteers":22,"sex":26,"minAge":27,"maxAge":28,"enrollmentInfo":29,"targetDuration":7,"studyType":32,"phases":7,"briefSummary":33,"conditions":34,"keywords":7,"overallStatus":37,"whyStopped":7,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":7},{"fullName":5,"class":6},"First Affiliated Hospital Xi'an Jiaotong University","OTHER",null,[9,14],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Zhuonan Wang","CONTACT","15332359525","wangzhuonan@xjtu.edu.cn",{"name":15,"role":11,"phone":16,"phoneExt":7,"email":17},"Jiawen Hu","15291910551","hujiawen@stu.xjtu.edu.cn",{"type":19,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100581786","the-value-of-combined-detection-of-different-blood-biomarkers-in-the-diagnosis-and-treatments-of-traumatic-brain-injury-100581786",false,"NCT06854835","The Value of Combined Detection of Different Blood Biomarkers in the Diagnosis and Treatments of Traumatic Brain Injury","Inclusion Criteria:\n\n1. Age: 18-65 years old\n2. Time of injury: patients with acute traumatic brain injury within 24h\n3. Glasgow Coma Scale (Glasgow Coma Scale, GCS) score: 13 to 15 for patients with mild traumatic brain injury, 9 to 12 for moderate traumatic brain injury, and 3 to 8 for patients with severe traumatic brain injury\n4. No other system damage has occurred\n5. Admitted to hospital for the first diagnosis after the injury\n\nExclusion Criteria:\n\n1. With a history of neurological or psychiatric disorders\n2. Traumatic brain injury occurred before the injury\n3. History of alcohol or substance abuse\n4. Mild brain trauma is a complication of other injuries (systemic trauma, facial trauma, or spinal cord trauma) or other causes (psychological trauma, language impairment)\n5. Patients without visits, and incomplete data during treatment","ALL","18 Years","65 Years",{"count":30,"type":31},80,"ESTIMATED","OBSERVATIONAL","TBI, as a potential risk factor, causes a 1.5 times higher risk of neurodegenerative disease to up to 30-70% of TBI patients with neurological symptoms. Brain trauma is an important global medical, public health and social problem. Early diagnosis and effective treatment can effectively reduce the disability rate of patients and the incidence of neurological sequelae, and has increasingly become the focus of the international scientific research community. Exploring blood-based biomarkers has potential clinical value, which can greatly help clinicians to evaluate patients' conditions and develop reasonable plans, and then improve the clinical management and treatment of patients with craniocerebral trauma. Further research work is needed to be done to identify the most effective and efficient biomarker or combination marker strategies for integration into clinical treatment.",[35,36],"Brain Injuries, Traumatic","Biomarkers","NOT_YET_RECRUITING","2025-02-25",{"date":40,"type":41},"2025-03-03","ACTUAL",{"date":43,"type":31},"2025-03-15",{"date":45,"type":31},"2027-07-31",{"name":5,"class":6}]