[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615909":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":37,"locations":10,"responsibleParty":47,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":52,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":72,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":10},{"fullName":5,"class":6},"Sohag University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Systemic lupus erythematosis",null,"patients proved with SLE",[13],"Diagnostic Test: measuring gene expression",{"label":15,"type":10,"description":16,"interventionNames":17},"Idiopathic thrombocytopenic purpura","patients proved with ITP",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Normal controls","normal persons showing no disease matching age and gender",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"DIAGNOSTIC_TEST","measuring gene expression","* 5 ml peripheral blood collected under sterile conditions.\n* Separation of PBMCs (peripheral blood mononuclear cells). for :\n\n  1. RNA Extraction: from PBMCs.\n  2. cDNA Synthesis: using reverse transcriptase.\n  3. Gene Expression Analysis using Quantitative Real-Time PCR (qRT-PCR)",[15,19,9],[29,33],{"name":30,"affiliation":31,"role":32},"Marwa Z elsayed, Lecturer","faculty of Medicine Sohag university","PRINCIPAL_INVESTIGATOR",{"name":34,"affiliation":35,"role":36},"Samar M Kamal, lecturer","fauculty of Medicine , Sohag university","STUDY_CHAIR",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":10,"email":42},"Noha S Shafik, professor","CONTACT","01067261504","nohasaber@med.sohag.edu.eg",{"name":44,"role":40,"phone":45,"phoneExt":10,"email":46},"Dina H Mohmad, lecturer","01119886946","dinahamada87@yahoo.com",{"type":32,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Noha Saber Shafik","Assistant professor","100615909","the-value-of-interleukin-1-and-interleukin-33-genetic-expression-in-the-pathogenesis-and-differentiation-of-primary-itp-and-sle-related-thrombocytopenia-100615909",false,"NCT07298733","The Value of Interleukin-1β and Interleukin-33 Genetic Expression in the Pathogenesis and Differentiation of Primary ITP and SLE-Related Thrombocytopenia","Inclusion Criteria:\n\n* • Adults (18-60 years).\n\n  * Diagnosed primary ITP\n  * Diagnosed SLE with thrombocytopenia\n\nExclusion Criteria:\n\n* • Patients on recent immunosuppressive therapy (\\\u003C4 weeks).\n\n  * Co-existing infections, malignancies, or other autoimmune cytopenias","ALL","18 Years","60 Years",{"count":60,"type":61},300,"ESTIMATED","OBSERVATIONAL","Primary immune thrombocytopenia (ITP) is an autoimmune- mediated acquired bleeding disorder, defined as a platelet count less than 100×109\u002FL without other causes of isolated thrombocytopenia. The etiology of ITP is complex and heterogeneous, and as no specific biomarkers are indicating its presence, ITP remains a diagnosis of exclusion. The heterogeneous nature of ITP is evident in the differences in clinical presentation and response to regular treatment among patients and the multiple mechanisms that have been forwarded to account for it, such as autoantibodies, T cell dysregulation, and impaired megakaryocytes. Except primary ITP, all forms of immune-mediated thrombocytopenia is defined as secondary ITP. Secondary ITP has several causes, including autoimmune diseases such as systemic lupus erythematosus",[65,66],"Immune Thrombocytopenia","System; Lupus Erythematosus",[68,69,70,71],"gene expression","ITP","inflammation","autoimmune","NOT_YET_RECRUITING","2025-12-09",{"date":75,"type":76},"2025-12-23","ACTUAL",{"date":78,"type":61},"2026-01-01",{"date":80,"type":61},"2026-12-31",{"name":5,"class":6}]