[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100580602":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":11,"centralContacts":25,"locations":11,"responsibleParty":31,"collaborators":11,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":41,"eligibilityCriteria":42,"healthyVolunteers":37,"sex":43,"minAge":44,"maxAge":45,"enrollmentInfo":46,"targetDuration":11,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":11,"overallStatus":55,"whyStopped":11,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":11},{"fullName":5,"class":6},"Cairo University","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":11},"painful cases with disc displacement with reduction","ACTIVE_COMPARATOR",null,{"label":13,"type":14,"description":11,"interventionNames":15},"painful cases of disc displacement with reduction","EXPERIMENTAL",[16],"Other: hypertonic saline 5% sodium chloride",[18,22],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":11},"hypertonic saline 5% sodium chloride","Hypertonic saline acts as an analgesic by alleviating nociceptive pain from inflamed tissues, which may include bone, connective tissue , synovium , or a combination of these Hypertonic saline results in safe and remarkable outcomes on knee pain, stiffness and function compared with intra-articular dextrose injection",[13],{"type":6,"name":23,"description":24,"armGroupLabels":11,"otherNames":11},"hypertonic dextrose 20%","A recent study showed the sensorineural analgesic effect of 5% dextrose prolotherapy in the treatment of chronic low back pain ,Therefore, the mechanism of action for dextrose prolotherapy is hypothesized to work through reducing peripheral sensitization and targeting structural dysfunction",[26],{"name":27,"role":28,"phone":29,"phoneExt":11,"email":30},"aya allah gamal salah, bachelors degree","CONTACT","+20 1005557843","ayaallah.gamal@dentistry.cu.edu.eg",{"type":32,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Aya Allah Gamal Salah","Aya Allah Gamal","100580602","therapeutic-effect-of-using-injectable-hypertonic-saline-5-versus-injectable-dextrose-20-on-pain-in-painful-cases-of-disc-displacement-with-reduction-100580602",false,"NCT06839430","Therapeutic Effect of Using Injectable Hypertonic Saline 5% Versus Injectable Dextrose 20% on Pain in Painful Cases of Disc Displacement With Reduction","Therapeutic Effect of Using Injectable Hypertonic Saline 5% Versus Injectable Dextrose 20% on Pain in Painful Cases of Disc Displacement With Reduction ( A Randomized Clinical Trial)","RCT","Inclusion Criteria:\n\n* presence of one or more of the following observations in one or both temporomandibular joints:\n\n  1. pain.\n  2. audible clicking.\n  3. mandibular deviation on opening.\n  4. Failure of conservative treatment\n\nExclusion Criteria:\n\n* The clinical or radiographic signs of disc displacement without reduction, osteoarthritis, or articular bony changes.\n\n  * Previous TMJ surgery, arthrocentesis, , or the presence of any systemic disease that would affect the TMJ anatomy or mechanical function.\n  * A history of allergic reactions to any components of the injectable solution.\n  * Infection of the affected joint and pre-auricular area.\n  * Previous surgery of the affected joint","ALL","15 Years","75 Years",{"count":47,"type":48},20,"ESTIMATED","INTERVENTIONAL",[51],"NA","This study is aiming to assess effect of hypertonic saline 5% in comparison to dextrose 20% on pain ,inter-insical opening and movements of jaw in painful cases of disc displacement with reduction",[54],"TMJ Disc Displacement With Reduction","NOT_YET_RECRUITING","2025-03-06",{"date":58,"type":59},"2025-03-07","ACTUAL",{"date":61,"type":48},"2025-08-20",{"date":63,"type":48},"2026-09-20",{"name":5,"class":6}]