[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100505122":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":33,"responsibleParty":102,"collaborators":19,"id":104,"slug":105,"hasResults":106,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":106,"sex":112,"minAge":113,"maxAge":19,"enrollmentInfo":114,"targetDuration":19,"studyType":117,"phases":118,"briefSummary":120,"conditions":121,"keywords":124,"overallStatus":130,"whyStopped":19,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":140},{"fullName":5,"class":6},"Centre Hospitalier Universitaire de Saint Etienne","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Fasting mimicking diet (FMD)","EXPERIMENTAL","patients aged 65 and over, institutionalized in Long Term Care Units (USLD) or Establishments for the elderly (EHPAD).",[13],"Dietary Supplement: Fasting mimicking diet (FMD)",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DIETARY_SUPPLEMENT","D1 will correspond to a \"pre-fasting\" phase, with about 800 kcal of intake (approximately 40% of normal caloric intake) from a mono-nutrient diet (fruit, rice or potato according to the patient's preferences). Then D2 and D3 will correspond to the days of actual fasting, with 200-350 kcal of intake (10-18% of normal caloric intake) in the form of 100 ml of broth or vegetable juice (with a teaspoon of linseed oil) three times a day, and vaccination will take place on D4, after returning to a normal diet. 2 to 3 liter of water or unsweetened drink per day is required.Laxatives (unsweetened) will be prescribed and can be taken as during the fasting period.",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Baptiste GRAMONT, MD","Baptiste.Gramont@chu-st-etienne.fr","PRINCIPAL_INVESTIGATOR",[26,30],{"name":22,"role":27,"phone":28,"phoneExt":29,"email":23},"CONTACT","(0)0477829641","+33",{"name":31,"role":27,"phone":19,"phoneExt":19,"email":32},"Florence RANCON, CRA","florence.rancon@chu-st-etienne.fr",[34,50,64,79,89],{"facility":35,"status":19,"city":36,"state":19,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"EHPAD Claudinon","Le Chambon-Feugerolles","42500","France","FR",{"type":41,"coordinates":42},"Point",[43,44],4.32149,45.39145,{"lat":44,"lon":43},[47,49],{"name":48,"role":27,"phone":19,"phoneExt":19,"email":19},"Romain JUGAND, MD",{"name":48,"role":24,"phone":19,"phoneExt":19,"email":19},{"facility":51,"status":19,"city":52,"state":19,"zip":53,"country":38,"countryCode":39,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"EHPAD Les Cèdres Malataverne","Malataverne","43200",{"type":41,"coordinates":55},[56,57],4.75326,44.48525,{"lat":57,"lon":56},[60,62],{"name":61,"role":27,"phone":19,"phoneExt":19,"email":19},"Aurélie BUISSON, MD",{"name":63,"role":24,"phone":19,"phoneExt":19,"email":19},"Aurélie BUISSON",{"facility":65,"status":19,"city":66,"state":19,"zip":67,"country":38,"countryCode":39,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"CHU de Saint-Etienne","Saint-Etienne","42055",{"type":41,"coordinates":69},[70,71],4.39,45.43389,{"lat":71,"lon":70},[74,75,76],{"name":22,"role":27,"phone":19,"phoneExt":19,"email":19},{"name":22,"role":24,"phone":19,"phoneExt":19,"email":19},{"name":77,"role":78,"phone":19,"phoneExt":19,"email":19},"Martin KILLIAN, MD","SUB_INVESTIGATOR",{"facility":80,"status":19,"city":66,"state":19,"zip":19,"country":38,"countryCode":39,"cosmosGeoPoint":81,"geoPoint":83,"contacts":84},"EHPAD de la Talaudière, la Rivière, la Croix de l'Horme",{"type":41,"coordinates":82},[70,71],{"lat":71,"lon":70},[85,87],{"name":86,"role":27,"phone":19,"phoneExt":19,"email":19},"Thomas CELARIER, PhD",{"name":88,"role":24,"phone":19,"phoneExt":19,"email":19},"Thomas CELARIER",{"facility":90,"status":19,"city":91,"state":19,"zip":92,"country":38,"countryCode":39,"cosmosGeoPoint":93,"geoPoint":97,"contacts":98},"EHPAD La M.R.L","Saint-Just-Saint-Rambert","42170",{"type":41,"coordinates":94},[95,96],4.24141,45.49973,{"lat":96,"lon":95},[99,101],{"name":100,"role":27,"phone":19,"phoneExt":19,"email":19},"Anne PAVY, MD",{"name":100,"role":24,"phone":19,"phoneExt":19,"email":19},{"type":103,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100505122","therapeutic-fasting-and-immune-aging-100505122",false,"NCT05857241","Therapeutic Fasting and Immune Aging","Therapeutic Fasting and Immune Aging: A Pilot Study of Tolerance","JÛVENILE","Inclusion Criteria :\n\n* Patient affiliated or entitled to a social security scheme\n* Residing in a Long-Term Care Unit (LTCU) or a Facility for the Elderly Dependent (EHPAD)\n* A person deemed a priori, by the geriatrician member of the monitoring committee, to be capable of following the dietary recommendations required for the study.\n* A person deemed a priori, by the clinician in charge, to be able to follow the dietary recommendations required by the study.\n* Patient who has received informed information about the study and has co-signed a consent to participate in the study with the investigator.\n\nExclusion Criteria :\n\n* Inability and\u002For unwillingness to follow dietary recommendations and\u002For perform follow-up examinations required for the study\n* Iso-resource group 1 or 2 according to the AGGIR grid\n* BMI \\\u003C 18.5 kg\u002Fm2 or recent weight loss \\> 5% in 1 month or recent weight loss \\> 10% in 6 months from previous weight\n* Albuminemia \\\u003C 30g\u002Fl\n* All swallowing disorders requiring a specific diet.\n* Influenza vaccination received prior to inclusion\n* Episode of influenza or suspected influenza during the 2020-2021 season and prior to inclusion\n* Any acute medical or surgical event less than 2 weeks prior to inclusion\n* Presence of systemic inflammatory or autoimmune disease\n* Presence of an innate or acquired immune deficiency (including taking immunosuppressive treatment)\n* Presence of a chronic disease which, according to the physician, makes the follow-up of a \"fasting diet\" and\u002For the consumption of large amounts of liquids (cf. fasting diet modalities) risky (e.g. insulin-dependent or insulin-requiring diabetes, severe heart failure, severe kidney failure, active cancer, significant undernutrition...) or impossible (e.g. advanced neurodegenerative pathology).","ALL","65 Years",{"count":115,"type":116},20,"ESTIMATED","INTERVENTIONAL",[119],"NA","Immunosenescence is the age-related decline of the immune system, involving a state of chronic inflammation and a decrease in the diversity\u002Fadaptability of the lymphocyte repertoire. The consequences of immunosenescence are multiple, including increased susceptibility to infections and poorer vaccine responses.",[122,123],"Fasting","Diet, Healthy",[125,126,127,128,129],"Fasting mimicking diet","Aged","immunology","immunosenescence","tolerance","NOT_YET_RECRUITING","2025-04-07",{"date":133,"type":134},"2025-04-08","ACTUAL",{"date":136,"type":116},"2025-04",{"date":138,"type":116},"2026-03",{"name":5,"class":6},5]